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6 Cards in this Set
- Front
- Back
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Benzoyl peroxide cream, lotion, various concentrations
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Antimicrobial against P. acnes as well as comedolytic effects
Lower strength formula often as effective as higher strength and likely to cause less skin irritation Often given in combination with topical antibiotics |
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Tretinoin (Retin-A) cream, gel, various other concentrations
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Normalize hyperkeratinization, decreases cohesion between epidermal cells, increases epidermal cell turnover, significant anti-inflammatory effect
Mild to moderate skin irritation with redness and dryness common with initial use, improves over time; expect ~6 weeks of therapy before noting improvement Photosensitizing: advise sunscreen use |
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Oral antibiotics (clindamycin, erythromycin, tetracycline, minocycline, etc)
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Antimicrobial against P. acnes, anti-inflammatory
Indicated for the treatment of moderate papular inflammatory acne, usually when topical therapy is inadequate Once skin is clear (usually takes 3 months of continuous therapy), taper off slowly over a few months while adding topical antibiotic agents; rapid discontinuation results in return of acne to pretreatment baseline Long-term or repeat therapy is often needed |
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Topical antibiotics (clindamycin, erythromycin, tetracycline, etc)
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Antimicrobial against P. acnes, anti-inflammatory
Indicated in treatment of mild to moderate inflammatory acne vulgarism; less effective than oral antibiotics; often given in combination with benzoyl peroxide |
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Combined estrogen-progestin hormonal contraceptives (females only)
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Reduction in androgen levels, decreased sebum production
Can be in pill, ring, or patch form Takes about 3 months of use prior to significant improvement in skin If not working, would need to increase the amount of estrogen... |
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Isotretinoin (Accutane) capsules
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Likely inhibits sebaceous gland function
Indicated for treatment of cystic acne that does not respond to other therapies Usual course of treatment is 4-6 months, discontinue when nodule count is reduced by 70%; repeat course only if needed after 2 months off drug AE include cheilitis, conjunctivitis, hypertriglyceridemia, xerosis, photosenstitivity, potent teratogenicity Women must use 2 types of highly effective contraception while on this medication Careful monitoring for mood destabilization/suicidal thoughts |
