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31 Cards in this Set
- Front
- Back
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Lisinopril
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ACE-I
Prinivil - Zestril |
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Quinapril
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ACE-I
Accupril |
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Fosinopril
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ACE-I
Monopril |
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Ramipril
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ACE-I
Altace |
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Benazepril
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ACE-I
Lotensin |
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Enalapril
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ACE-I
Vasotec |
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Benazepril/Amlodipine
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ACE-I
Lotrel |
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ACE-I Mechanism
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Block angiotensin converting enzyme>decreasing production of aldosterone (which causes fluid/water retention)and angiotensin II (vasoconstrictor)
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ACE-I Indications
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Hypertension
Congestive Heart Failure |
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ACE-I Contraindications
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*Bilateral renal artery stenosis
*History of angioedema related to ACE-I therapy *Primary hyperaldosteronism *Pregnancy (Black Box Warning) |
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ACE-I Precautions
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Hyperkalemia
Renal impairment Hypovolemia |
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ACE-I Adverse Effects
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Hypotension
Hyperkalemia Cough Decreased glomerular filtration rate Angioedema (rare) |
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ACE-I Pharmacokinetics
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Primary route of elimination is renal except for fosinopril - so fosinopril does not need dosage adjustment in renal impairment
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ACE-I Monitoring
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Blood pressure
Serum potassium Blood urea nitrogen Serum creatinine |
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ACE-I Drug-Drug Interactions
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*Potassium supplements - hyperkalemia
*Triamterene - hyperkalemia *NSAIDs - reduced efficacy for hypertension |
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ACE-I Counseling Highlights
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*Do not stop abruptly w/o consulting prescriber
*Report symptoms of hypotension, hypovolemia or persistent cough *Discontinue immediately is swelling in mouth or throat *Report pregnancy to physician as soon as possible |
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Valsartan
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ARBs
Diovan |
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Losartan
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ARBs
Cozaar |
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Irbesartan
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ARBs
Avapro |
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Candesartan
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ARBs
Atacand |
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Olmesartan
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ARBs
Benicar |
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ARBs Mechanism
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Blocks angiotensin II receptors>reduces angiotensin II and aldosterone activity
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ARBs Indications
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*Hypertension
*Congestive Heart Failure |
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ARBs Contraindications
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*Bilateral renal artery stenosis
*Primary hyperaldosteronism *Pregnancy (Black Box Warning) |
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ARBs Precautions
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*Hyperkalemia
*Renal impairment *Severe hepatic dysfunction |
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ARBs Adverse Effects
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*Hypotension
*Hyperkalemia *Decreased glomerular filtration rate |
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ARBs Pharmacokinetics
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Primary route of elimination is hepatic
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ARBs Monitoring
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*Blood pressure
*Serum potassium *Blood urea nitrogen *Serum creatinine |
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ARBs Drug-Drug Interactions
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*Potassium supplements - hyperkalemia
*Triamterene - hyperkalemia *NSAIDs - reduced efficacy for hypertension |
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ARBs Drug-Food Interactions
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High salt diet - reduced efficacy for hypertension and may cause CHF exacerbation
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ARBs Counseling Highlights
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*Do not stop abruptly w/o consulting prescriber
*Report symptoms of hypotension or hypovolemia *Report pregnancy to physician as soon as possible |
