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31 Cards in this Set

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Lisinopril
ACE-I
Prinivil - Zestril
Quinapril
ACE-I
Accupril
Fosinopril
ACE-I
Monopril
Ramipril
ACE-I
Altace
Benazepril
ACE-I
Lotensin
Enalapril
ACE-I
Vasotec
Benazepril/Amlodipine
ACE-I
Lotrel
ACE-I Mechanism
Block angiotensin converting enzyme>decreasing production of aldosterone (which causes fluid/water retention)and angiotensin II (vasoconstrictor)
ACE-I Indications
Hypertension
Congestive Heart Failure
ACE-I Contraindications
*Bilateral renal artery stenosis
*History of angioedema related to ACE-I therapy
*Primary hyperaldosteronism
*Pregnancy (Black Box Warning)
ACE-I Precautions
Hyperkalemia
Renal impairment
Hypovolemia
ACE-I Adverse Effects
Hypotension
Hyperkalemia
Cough
Decreased glomerular filtration rate
Angioedema (rare)
ACE-I Pharmacokinetics
Primary route of elimination is renal except for fosinopril - so fosinopril does not need dosage adjustment in renal impairment
ACE-I Monitoring
Blood pressure
Serum potassium
Blood urea nitrogen
Serum creatinine
ACE-I Drug-Drug Interactions
*Potassium supplements - hyperkalemia
*Triamterene - hyperkalemia
*NSAIDs - reduced efficacy for hypertension
ACE-I Counseling Highlights
*Do not stop abruptly w/o consulting prescriber
*Report symptoms of hypotension, hypovolemia or persistent cough
*Discontinue immediately is swelling in mouth or throat
*Report pregnancy to physician as soon as possible
Valsartan
ARBs
Diovan
Losartan
ARBs
Cozaar
Irbesartan
ARBs
Avapro
Candesartan
ARBs
Atacand
Olmesartan
ARBs
Benicar
ARBs Mechanism
Blocks angiotensin II receptors>reduces angiotensin II and aldosterone activity
ARBs Indications
*Hypertension
*Congestive Heart Failure
ARBs Contraindications
*Bilateral renal artery stenosis
*Primary hyperaldosteronism
*Pregnancy (Black Box Warning)
ARBs Precautions
*Hyperkalemia
*Renal impairment
*Severe hepatic dysfunction
ARBs Adverse Effects
*Hypotension
*Hyperkalemia
*Decreased glomerular filtration rate
ARBs Pharmacokinetics
Primary route of elimination is hepatic
ARBs Monitoring
*Blood pressure
*Serum potassium
*Blood urea nitrogen
*Serum creatinine
ARBs Drug-Drug Interactions
*Potassium supplements - hyperkalemia
*Triamterene - hyperkalemia
*NSAIDs - reduced efficacy for hypertension
ARBs Drug-Food Interactions
High salt diet - reduced efficacy for hypertension and may cause CHF exacerbation
ARBs Counseling Highlights
*Do not stop abruptly w/o consulting prescriber
*Report symptoms of hypotension or hypovolemia
*Report pregnancy to physician as soon as possible