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30 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What cytokine is the T lymphocyte survival signal?
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IL-2
What is IL-2's receptor? |
CD25
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What interleukin receptors share the common gamma chain?
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IL2, IL4, IL7, IL9, IL15, IL21
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What is the most common form of SCID? What is its molecular defect?
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x-linked SCID
Mutation of common gamma chain What IL receptors are affected? |
IL2, IL4, IL7, IL9, IL15, IL21
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How many immunoglobulin-like domains are there in a TCR?
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4 (2 variable Ig-domains, one on the alpha chain, one on the beta chain; 2 constant Ig-domains, one on the alpha chain, one on the beta chain)
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What is the binding site for superantigens?
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Variable-beta region of the TCR
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What proteins compose the TCR complex?
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TCR, CD3 (2 gamma, one delta, one epsilon), two zeta chains
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Are gamma-delta T-cells MHC restricted?
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No
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Can gamma-delta T-cells react to unprocessed antigens?
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Yes
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Do most gamma-delta T-cells possess CD4 or CD8?
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No
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What type of antigens do gamma-delta uniquely recognize?
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Lipids
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What do NKT cells recognize?
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Lipids presented in the context of CD1.
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What are the proximal signalling proteins for lck?
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CD4 and CD8 in T-cells
What protein family contains lck? |
Src homology
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What is the proximal signalling protein for fyn?
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CD3
What protein family contains fyn? |
Src homology
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What is the proximal signalling protein for SLAM?
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CD28 (which interacts with CD80/86)
What type of signalling motif is contained by SLAM? |
ITSM (immunoreceptor tyrosine switch motif)
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What is the proximal signalling protein for SAP?
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SLAM (SAP stands for SLAM-associated protein)
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Mutations in what molecule are associated with x-linked lymphoproliferative syndrome?
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SAP
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What is the proximal signalling protein for ZAP-70
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Zeta chains (which are phosphorylated by Lck).
What protein family contains ZAP-70? |
Syk family
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What is the lymphocyte profile of ZAP-70 deficiency?
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Low T cells, especially CD8.
Normal B cells, normal NK cells. |
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How do calcineurin inhibitors work?
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Binding immunophilins that inhibit calcineurin, thereby probihibiting NFAT phosphorylation and subsequent translocation to nucleus.
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What are the 3 B-cell Src kinases?
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Lyn, Fyn, Btk
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What protein (in B-cells) is equivalent to ZAP-70 (in T-cells)?
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Syk
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What protein (in B-cells) is equivalent to LAT (in T-cells)?
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BLNK (B-lymphocyte linker protein)
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What immunoglobulin isotype is primarily produced in T-independent B-cell responses?
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IgM
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What 2 types of B-cells primarily produce T-independent B-cell responses?
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B-1B cells
Marginal zone B cells. |
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What enzyme (in B-cells) is activated upon ligation of CD40?
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AID
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What protein is mutated in x-linked hyper-IgM?
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CD40L (CD154)
On what cell type is CD40L (CD154) expressed? |
T-cells
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What proteins may be mutated in AR hyper-IgM?
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CD40
AID UNG |
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Does x-linked hyper-IgM have lymphadenopathy?
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No (B-cells do not receive signal to proliferate)
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Does AR hyper-IgM due to AID deficiency have lymphadenopathy?
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Yes (B-cells receive signal to proliferate, but cannot class switch)
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How does Jak3 deficiency lead to SCID?
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Jak3 typically associates with common gamma chain (IL2R) and is needed for intracellular signalling. Therefore Jak3 deficiency does not allow T-cell to perceive survival signals.
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