Acaai Board Review, Chapter 1, Section 4 (Immunoglobulins)

Front 1

How many Ig constant regions are in the heavy chain of IgG?

Back 1

3

Front 2

How many Ig constant regions are in the heavy chain of IgA?

Back 2

3

Front 3

How many Ig constant regions are in the heavy chain of IgM?

Back 3

4

Front 4

How many Ig constant regions are in the heavy chain of IgD?

Back 4

3

Front 5

How many Ig constant regions are in the heavy chain of IgE?

Back 5

4

Front 6

To what Ig region does omalizumab bind?

Back 6

C-epsilon-3

Front 7

On what chromosome is the kappa light chain encoded?

Back 7

2

Front 8

On what chromosome is the lambda light chain encoded?

Back 8

22

Front 9

How many fragments are generated with papain digestion of IgG?

Back 9

3 (2 binding regions and 1 constant region)

Front 10

How many fragments are generated with pepsin digestion of IgG?

Back 10

2 (1 binding region with 2 separate binding sites and 1 constant region)

Front 11

Which Ig class can circulate as dimers?

Back 11

IgA

Front 12

Which Ig class can circulate as pentamers?

Back 12

IgM

Front 13

A numerically higher Kd indicates lower or higher affinity?

Back 13

lower

Front 14

Which Ig class is the first produced after birth and the first to reach adult level?

Back 14

IgM

Front 15

Which Ig class(es) cross the placenta?

Back 15

IgG only.

Front 16

Which Ig class has the highest plasma concentration?

Back 16

IgG

Front 17

Which Ig class has the highest total body concentration?

Back 17

IgA

Front 18

What protein is responsible for transporting IgA across the mucosal epithelium?

Back 18

poly-Ig receptor

Front 19

What Ig class is the most efficient at fixing complement?

Back 19

IgM

Front 20

What IgG subclass has the shortest half-life?

Back 20

IgG3

Front 21

What is rheumatoid factor?

Back 21

Antibody against the Fc portion of immunoglobulin.

(Usually IgM, but can be any other isotype)

Front 22

Which 2 IgG subclasses are most effective at fixing complement?

Back 22

IgG1 and IgG3

Front 23

Which IgG subclass is best for antibody dependent cell mediated cytotoxicity?

Back 23

IgG1

Front 24

Which IgA subclass is primarily in the respiratory tract?

Back 24

IgA1

Front 25

Which IgA subclass is primarily in the lower GI tract?

Back 25

IgA2

Front 26

Which Ig classes can fix complement?

Back 26

IgG and IgM

Front 27

Which IgG subclass is associated with a Th1 response?

Back 27

IgG1

Front 28

Which IgG subclass is assocaited with a Th2 response?

Back 28

IgG4

Front 29

Which IgG subclass is least efficiently transported across the placenta?

Back 29

IgG2

Front 30

Which 2 IgG subclasses are associated with protection against polysaccharides?

Back 30

IgG2 & IgG4

Front 31

2 cytokines characteristically associated with class switching to IgG1

Back 31

IFN-gamma
IL-4

Front 32

2 cytokines characteristically associated with class switching to IgG2

Back 32

IFN-gamma
TGF-beta

Front 33

1 cytokine characteristically associated with class switching to IgG3

Back 33

IFN-gamma

Front 34

2 cytokines characteristically associated with class switching to IgG4

Back 34

IL-4
IL-13

Front 35

2 cytokines characteristically associated with class switching to IgA

Back 35

TGF-beta
IL-5

Front 36

2 cytokines characteristically associated with class switching to IgE

Back 36

IL-4
IL-13

Front 37

What feature of Ig development is the most responsbile for variability?

Back 37

Junctional diversity (random, non-templated, addition or removal of nucleotide sequences at V/D/J junctions.

Front 38

What functional feature of Ig development is the most responsbile for fine-tuning antibody affinity?

Back 38

Somatic hypermutation (point mutations in V regions of rapidly dividing B lymphocytes and selective survival of b lymphocytes that produce high affinity antibodies)

Front 39

What is CD64, where is it expressed, and what is its function?

Back 39

Fc-gamma-RI (high affinity IgG receptor)

Macrophages, neutrophils, eosinophils.

Phagocytosis

Front 40

What is CD32, where is it expressed, and what is its function?

Back 40

Fc-gamma-RIIA. (Also can be Fc-gamma-RIIB.)

Macrophages, neutrophils, eosinophils, platelets. (B-cells.)

Low affinity IgG receptor; phagocytosis (poor); (Feedback inhibition of B-cells.)

Front 41

What is CD16, where is it expressed, and what is its role?

Back 41

Fc-gamma-RIIIA (or Fc-gamma-RIIIB)

NK cells (neutrophils)

Low affinity IgG receptor responsible for antibody dependent cell mediated cytotoxicity (phagocytosis, poor)

Front 42

What is Fc-epsilon-RI, where is it expressed, and what is its role?

Back 42

High affinitiy receptor for IgE

Mast cells, basophils, eos

Degranulation, antibody-dependent cell mediated cytotoxicity

Front 43

What is CD23, where is it expressed, and what is its role?

Back 43

Fc-epsilon-RII (low affinitiy IgE receptor)

Neutrophils, eosinophils, monocytes

Unknown function