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20 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Histone acetylation allows or represses gene transcription?
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Histone Acetylation ALLOWS gene transcription.
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Histone decactylation allows or represses gene transcription?
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Histone Deacetylation Deactivates gene transcription.
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What is the definition of epigenetics?
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Changes in gene function that occur without a change in the sequence of a gene.
What are 2 examples of epigenetic modification of the genome? |
DNA methylation
Histone modification |
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What 2 conditions are associated with SNP changes of the filaggrin gene?
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Atopic dermatitis
Asthma |
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What condition is associated with SNP changes of the ORMDL3 protein?
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Asthma
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What is the function of the filaggrin protein?
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Epidermal barrier function.
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What chromosome is the filaggrin gene located?
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Chromosome 1
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What percentage of patients with severe atopic dermatitis have SNP changes at at least 1 gene of the filaggrin gene?
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50%
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What clinical changes are associated with SNP of CD14?
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Both increased and decreased risk of asthma/atopy.
What is CD14? |
Lipopolysaccharide co-receptor (with TLR 4)
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What clinical changes are associated with SNP of CCR5?
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Protects against nonatopic asthma,
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What clinical changes are associated with SNPs of TLR7 and TLR 8?
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Increased risk of asthma, rhinitis, atopic dermatitis and specific IgE
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What clinical changes are associated with SNP of IL-13
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Increased risk of asthma, bronchial hyperresponsiveness, skin-test responsiveness, response to montelukast
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What clinical changes are associated with SNP of beta-2-adrenergic receptor?
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Associated with decreased albuterol response compared to gly/gly phenotype
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What clinical changes are associated with SNP of ADAM33?
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Increased risk of asthma and bronchial hyperresponsiveness.
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What relevant protein is associated with 17q12-21?
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ORMDL3.
What clinical association? |
Asthma
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What relevant protein is associated with 5q22-32?
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CD14
Function? Clincal relevance? |
LPS coreceptor
Increased and decrased asthma risk associated with SNP's |
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What relevant protein is associated with 3p21-22?
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CCR5
Function? Clinical relevance? |
Chemokine receptor
SNP protects against nonatopic asthma |
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What relevant protein is associated with Xp22?
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TLR7 and 8
Function? Clinical relevance? |
Pattern recognition for viral ssRNA
SNP confers increased risk for asthma, rhinitis, atopic dermatitis, increased specific IgE |
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What relevant protein is associated with 5q31?
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IL-13
Function? Clinical relevance? |
Cytokine associated with increased IgE secretion, mucous production, collagen synthesis.
SNP associated with increased risk of asthma, BHR, + skin tests, montelukast response |
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What relevant protein is associated with ADRB2?
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beta-2-adrenergic receptor
Arg phenotype with decrased albuterol response |
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