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26 Cards in this Set
- Front
- Back
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Clindamycin |
Lincosamide Bind to the 50s ribosomal subunit inhibiting protein synthesis |
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Lincomycin |
Lincosamide Bind to the 50s ribosomal subunit inhibiting protein synthesis |
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Chloramphenicol |
Other Bind to the 50s ribosomal subunit inhibiting the transpeptidation reaction Works on same site as Lincoasmides + Macrolides (grey baby syndrome) |
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Sodium Fusidate |
Other Inhibits protein synthesis by preventing the translocation of the peptide subunits Effective on MRSA |
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Mupirocin |
Other Inhibits protein synthesis by competing with isoleucine, preventing the formation of isoleucyl tRNA Effective against MRSA |
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Vancomycin |
Glycopeptide Inhibit cell wall synthesis by binding to the D-alanine residues stopping the elongation of the peptidoglycan backbone |
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Teicoplanin |
Glycopeptide Inhibit cell wall synthesis by binding to the D-alanine residues stopping the elongation of the peptidoglycan backbone |
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Daptomycin |
Lipopeptides The acyl tail inserts itself into the plasma membrane in the presence of Ca forming an ion channel that depolarises the cell |
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Bacitracin |
Peptide - Interferes with cell wall synthesis Blocks the regeneration of bactoprenol phosphate, the lipid carrier that is involved in the cell wall building blocks across the cell membrane |
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Polymyxin |
Peptide Act like cationic detergents, strongly interacting with phospholipids and disrupt the cell membrane |
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Gramicidin |
Peptide Affects cell membrane function, a mixture of closely related compounds |
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Metronidazole |
Nitroimidazole - prodrug The drug removes electrons form ferredoxin, causing the drug to become reduced. This reduced intermediate is highly reactive which then binds to DNA causing strand breakage "dazole" |
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Tinidazole |
Nitroimidazole - prodrug The drug removes electrons form ferredoxin, causing the drug to become reduced. This reduced intermediate is highly reactive which then binds to DNA causing strand breakage "dazole" |
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Ciprofloxacin |
Fluoroquinolone Inhibit DNA synthesis and replication by inhibiting the enzymes DNA gyrase and Topoisomerase IV "floxacin" |
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Moxifloxacin |
Fluoroquinolone Inhibit DNA synthesis and replication by inhibiting the enzymes DNA gyrase and Topoisomerase IV "floxacin" |
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Norfloxacin |
Fluoroquinolone Inhibit DNA synthesis and replication by inhibiting the enzymes DNA gyrase and Topoisomerase IV "floxacin" |
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Ofloxacin |
Fluoroquinolone Inhibit DNA synthesis and replication by inhibiting the enzymes DNA gyrase and Topoisomerase IV "floxacin" |
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Nitrofuratoin |
Urinary antimicrobials Sensitive bacteria reduce the drug into reactive intermediates that inhibit various enzymes and break strands of DNA. Urine pH > 8 |
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Hexamine Hippurate |
Urinary antimicrobials Drug is first dissociates in the liver into hexamine and hippuric acid. Hexamine then moves into the acidic urine where it is hydrolised into ammonia and formaldehyde (toxic to bacteria) |
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Quinupistin |
Streptogramins Inhibit protein synthesis by binding to the 50s ribosomal subunit |
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Dalfopristin |
Streptogramins Inhibit protein synthesis by binding to the 50s ribosomal subunit |
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Linezolid |
Streptogramin inhibits protein synthesis by binding to the P site of the 50s ribosomal subunit preventing the formation of the initiation complex |
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Isonaziad |
Tuberculosis Inhibits the biosynthesis of Mycolic acid which is an essential part of the cell wall. |
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Rifampicin |
Tuberculosis Acts early in transcription phase which blocks the transit of the growing RNA chain |
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Ethambutol |
Tuberculosis Inhibits cell wall formation by inhibiting arabinosyl transferase |
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Pyrazinamide |
Tuberculosis A synthetic analogue of nictinamide |
