Abx- Moa

Front 1

PCN

Back 1

inhibits cell wall synthesis via binding to PBPs

Front 2

cephalosporins

Back 2

inhibits cell wall synthesis via binding to PBPs

Front 3

carbapenems

Back 3

inhibits cell wall synthesis via binding to PBPs

Front 4

monobactams (aztreonam)

Back 4

inhibits cell wall synthesis via binding to PBPs

Front 5

macrolides

Back 5

binds to 50S ribosome to halt translation

Front 6

lincosamides

Back 6

binds to 50S ribsome to halt translation

Front 7

sulfonamides

Back 7

inhibits folic acid synthesis, via binding to tetrahydropteroic acid with a higher affinity than PABA, acting as a false substrate, which inhibits the enzyme dihydropteroate synthetase from making dihydropteroic acid

Front 8

dapsone

Back 8

inhibits folic acid synthesis, via binding to tetrahydropteroic acid with a higher affinity than PABA, acting as a false substrate, which inhibits the enzyme dihydropteroate synthetase from making dihydropteroic acid

Front 9

trimethoprim

Back 9

binds to and inhibits dihydrofolate reductase enzyme (higher affinity for bacteria than protozoa or humans)

Front 10

pyrimethamine

Back 10

binds to and inhibits dihydrofolate reductase enzyme (higher affinity for protozoa and humans than for bacteria)

Front 11

fluoroquinolones

Back 11

inhibit DNA gyrase and topoisomerase IV, preventing replication/DNA repair

Front 12

aminoglycosides

Back 12

binds to 30S ribosome to interefere with translation

Front 13

glycopeptides

Back 13

(vancomycin)
inhibits cell wall synthesis by binding to peptidoglycan itself to prevent cross-linking

Front 14

lipopeptides

Back 14

(daptomycin)
causes cell wall depolarization (inserts lipophilic tail thru cell wall into cytoplasm, causing a K+ efflux, leading to depolarization and cell death w/o lysis)

Front 15

lipo-glycopeptides

Back 15

(telavancin)
two-fold:
1) like glycopeptides (vancomycin), binds to peptidoglycan to prevent cross-linking
2) like lipopeptides (daptomycin), causes cell wall depolarization

Front 16

oxazolidinones

Back 16

linezolid
prevents the formation of the 70S ribosomal subunit, via binding to the 50S and interferring with the incorporation of the 30S