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14 Cards in this Set
- Front
- Back
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PCN
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-cidal
time dependent |
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cephalosporins
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-cidal
time-dependent |
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carbapenems
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-cidal
time dependent |
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monobactams
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-cidal
time dependent |
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macrolides
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-static
debate over concentration dependent or time dependent (due to pt intolerance, they are dosed in a manor that makes them time dependent) |
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lincosamides
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can be -cidal or -static, depending on organism, inoculum, drug concentration
(likely static against S. aureus) debate over concentration dependent or time dependent (due to pt intolerance, they are dosed in a manor that makes them time dependent) |
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sulfonamides
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bacteriostatic
time-dependent killing |
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fluoroquinolones
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rapidly bactericidal
concentration-dependent |
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aminoglycosides
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rapidly bactericidal
concentration-dependent |
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glycopeptides
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(vancomycin)
can be static or cidal (depends on the distribution to the site of infection, inoculum size, protein-binding, and the organism) **PAE only exists at high concentrations time-dependent, although concentration matters AUC/MIC > 400 associated with best outcomes "concentration-INdependent |
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lipopeptides
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(daptomycin)
rapidly bactericidal concentration-dependent |
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lipo-glycopeptides
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(telavancin)
rapidly bactericidal concentration-dependent |
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streptogramins
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dalfoprisitin/quinupristin
*bactericidal in combination, bacteriostatic alone primarily time dependent (significant PAE for gram + bacteria!!) |
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oxazolidinone
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linezolid
static time dependent |
