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25 Cards in this Set
- Front
- Back
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cephalosporins
1st generation (2) |
cefazolin
cephalexin |
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cephalosporin coverage
1st generation |
GPC + PEcK (GNR)
Proteus, E. coli, Klebsiella |
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cephalosporins
2nd generation (4) |
cefuroxime
cefotetan cefoxitin cefaclor |
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cephalosporin coverage
2nd generation |
GPC + HEN PEcKS (GNR)
HIB, Enerobacter, Neisseria Proteus, E. coli, Klebsiella, Serratia |
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cephalosporins
3rd generation (4) |
ceftriaxone
cefotaxime ceftazidime cefixime |
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cephalosporins for meningitis
why? |
ceftriaxone
cefotaxime good penetration BBB |
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cephalosporins
toxicity |
cross hypersensitivity
with PCN in 5-10% of patients |
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cephalosporin coverage
3rd generation |
incr GN , decr GPC
meningitis enterics pseudomonas |
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cephalosporin
pseudomonas coverage |
ceftazidime
(3rd generation) |
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cephalosporins
4th generation |
cefepime
|
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|
cephalosporins coverage
4th generation |
anti-pseudomonal
GN, incr GP wrt 3rd gen'n strep, MSSA aerobic GN (E. coli, enterobacter, Klebsiella, Pseudomonas) |
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monobactam
|
aztreonam
|
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monobactam
coverage |
GNR:
Klebsiella, Pseudomonas, Serratia |
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carbapenems
(3) |
imipenem / cilastin
(decr inactivation in renal tubules) meropenem ertapenem |
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carbapenems
toxicity |
seizures (less with meropenem)
skin rash |
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carbapenems
coverage |
GPC, GNR, anaerobes
*Enterobacter |
|
|
vancomycin
coverage |
GPC
multi drug resistant staph aureus C. diff (po) |
|
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vancomycin
toxicity |
NOT + Red Man
nephrotoxicity ototoxicity thrombophlebitis "red man" = diffuse flushing |
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|
vancomycin
treatment for red man toxicity |
antihistamine
slow infusion |
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aminoglycosides
(5) |
GNATS
Gentamicin, Neomycin Amikacin, Tobramycin Streptomycin |
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|
aminoglycosides
toxicity |
NOT
nephrotoxicity (esp w cephalosporins) ototoxicity (esp w loop diuretics) teratogen |
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aminoglycosides
coverage |
GNR
synergy with beta-lactams |
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metronidazole
coverage |
anaerobic infections below the diaphragm
Metro: GET GAP (Giardia, Entamoeba, Trichomonas Gardnerella, Anaerobes, h. Pylori ) Anaerobes: Clostridium, Bacteroides |
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metronidazole
toxicity |
with EtOH
disulfuram - like reaction |
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|
C. diff
treatment |
clostridium difficile
oral vancomycin metronidazole |
