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41 Cards in this Set
- Front
- Back
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Which drugs affect cell wall?
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1) PCN (& all the -cillins)
2) Ceph 3) Imepinem/ Cilistatin 4) Aztreonam 5) Capsofungin (antifungal) 6) Vanc 7) Bacitracin |
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PCN (and all -cillins)
MOA: uses: S/E: |
MOA:
1) Activate Autolytic enzymes 2) Bind PCN binding proteins (in cell wall 3) Cross-linking of peptidoglycan (cell wall) in "ABC" uses: all gm +, anearobes S/E: HTY, hemolytic anemia, interstitial nephritis |
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Which particular cillin gives
1) rash 2) hemolytic anemia 3) interstitial neph 4) pseudomem colitis |
1) ampicillin
2) PCN 3) methicillin 4) amp/amox |
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Which -cillins are B-lactamase (PCNase) resistant?
ie, which drugs can kill bugs with B-lactamase |
methicillin, nafcillin, dicloxacillin, cloxacillin, oxacillin
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Which -cillins can be given w a B-lactamase inh (cavulinic acid)?
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amox, amp. tica, carb, piper
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-cillins for Staph A (not MRSA)
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naf, doclox, clox, ox
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-cillins for pseuedomonas
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Tica, Carben, Piper
"Take Care of Pseudomonas" |
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-cillins for gm neg rods
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Tica, Carben, Piper
"Take Care of Pseudomonas and all other gm - rods" |
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MRSA Rx:
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Vancomycin
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vancomycin resistant Staph A
(Vanc resistant anything) Rx: |
Linezolid
Daptomycin |
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Examples of B lactamase inh
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1) Tazobactam
2) Sulbactam 3) Clavulinic acid |
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Cephalosporins
MOA: S/E: |
MOA: same as PCN
S/E: HTY, disulfuram rxn (i think, bc its a lactam) |
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1st gen cephs cover...
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Proteus
Ecoli Klebsiella (PEK; urinary tract infxn bugs) |
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2nd gen cephs cover...
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Hib
Enterobacter Neiserria Serratia Proteus Ecoli Klebsiella "HENS PEK" |
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3rd gen cephs cover...
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Gm neg
(***esp Pseudo) |
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4th gen cephs cover...
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Gm neg
(esp ***Pseudo) |
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5th gen cephs cover...
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Gm neg
Pseudo |
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Name the 1st gen ceph
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end in "IN"
(cefoxitin is the only ceph that is not a 1st gen that ends in "IN") -cefoxitin is a 2nd gen ceph |
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Name the 4th gen ceph
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Cefepime
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Name the 3 gen ceph
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tax
triax raz taz tiz fix |
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Which 3rd gen cephs cross BBB?
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tAX, triAX
(AX through skull) |
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Which 3rd gen cephs are for pseudo?
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"az"
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Name the 2nd gen cephs
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If it does not
1) end in "IN" 2) have tax, triax, taz, raz, tiz, fix 3) its not cefepime (4th gen) assume its 2nd gen |
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Only 2nd gen that ends in "IN" (like all the 1st gen)
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Cefoxitin
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Which 2nd gen can treat anearobes?
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ceFOTetan
ceFOXitin "FOX FOT the anearobe" |
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Which generation ceph can cause disulfuram rxns?
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1st gen (not sure, it could be all the cephs cause disulfuram)
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Since cephs have same MOA as -cillins, are they succeptible to B-lactams?
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not as succeptible as -cillins.
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Which PCN is IV form?
oral form? |
IV: PCN G
oral: PCN V |
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Vancomycin:
MOA: uses: S/E: |
MOA: inh cell wall FORMATION (actually prevents wall from being made) by binding D-ala D-ala portion of cell wall precursors; binds P55
uses: MRSA, Staph. epididimis, enterococcal meningitis S/E: Thrombophlebitis Ototoxic Redman Syndrom Nephrotoxic "TORN" |
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If vanc cannot contain Staph or Enterococcus (VRE, VRSA) what do we give?
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linezolid
daptomycin |
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Pseudomem colitis:
causes: Rx: |
causes
Cephalosporins Clinda Amox Amp Any Abx Rx: Metro (p.o), Vanc (best) |
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Rx to Redman Synd
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change rate at with you administer Vanc
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Can pts with PCN allergies get cephs?
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no
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Aztreonam
MOA: uses: S/E: |
MOA: binds to PCN binding protein 3
"azTHREEonam" uses: Pseudomonas Gm neg Klebsiella Serratia "henSpeK from 2nd gen ceph and pseudo/gm neg from 3rd gen" ***for pts with PCN/ceph allergy, for pts with renal failure |
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Imepenem
MOA: uses: S/E: |
MOA: inh peptidoglycan cross-linking of cell wall
uses: DOC for pancreatitis, DOC for Enterobacter S/E: seizures, GI upset, HPY |
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Since Imepenem has a similar MOA as PCN, is it succeptable to B-lactamase?
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NO!!! it is HIGHLY resistant!
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always give imepenem with ...
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Cilistatin
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Cilistatin
MOA: uses: |
MOA: inh dihydropeptidase 1 (enzyme found in kidney)
uses: always with Imepenem |
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Since Aztreonam has a similar MOA as PCN, is it succeptable to B-lactamase?
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no, it is resistant to B-lactams, bc its a monobactam (it has a single B lactam ring, so is more discrete)
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B lactams:
hierarchy of resistance to B lactase |
B-lactams: -cillins, cephs, Imepenem, Aztreonam
PCN< Amp/Amox= Tica/Carb/Piper< Meth/Naf/Diclox/Clox/Ox < Cephs < Imepnem = Aztreonam |
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Which class of Abx gives the best
H infl B coverage? Which single abx gives the best H infl B coverage? |
2nd generation ceph
cefuroxime |
