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70 Cards in this Set
- Front
- Back
how much of the total body water is intracellular?
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Two thirds, 2/3
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in which cell is most of the bodies intracellular water?
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Muscle
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what is the most common cause of volume overload?
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Iatrogenic
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what is responsible for the plasma interstitial osmotic pressure gradient?
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Proteins, mainly albumin
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what is responsible for the intracellular – extracellular pressure gradient?
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Sodium
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how many mEq of sodium and chloride does a liter of 0.9% normal saline contain?
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154 mEq of each
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what are all the electrolytes in lactated ringers? And mEq of each?
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sodium 130, chloride 109, lactate 28, potassium 4, calcium 3
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how is plasma osmolarity calculated?
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(2Na) x (Glucose/18) x (BUN/2.8)
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how is free water deficits calculated?
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0.6 x kg x [(Na/140) -1]
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what drop in measured sodium does each 100 mg/dL rise in glucose cause?
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3 mEq/L drop in measured sodium for every 100 mg/dL rise in glucose
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what is the effect of acidosis on serum calcium?
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Acidosis promotes calcium disassociation from albumin. Acidosis therefore causes increased free/ionized calcium
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how much fluid is lost to evaporation and open abnormal cases?
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Up to 1 L per hour
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how much fluid is lost to insensible fluid losses? (sweat, respiration, etc.)
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up to 10 mL per kilogram per day
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what is the benefit to switching to dextrose containing IV fluids after G.I. surgery?
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Dextrose will stimulate insulin release, enhance amino acid uptake and protein synthesis which will prevent catabolism
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how many grams of dextrose does a liter of D5W contain?
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50 g
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how much fluid is secreted by the stomach per day?
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1 to 2 L per day
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how much food is secreted by each of pancreas, duodenum, and biliary system?
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Each produce up to 1 L per day
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what are daily and potassium requirements?
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1 mEq per kilogram per day
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which body fluid has the highest concentration of potassium?
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Saliva
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what effect does increase flow have on pancreatic/biliary secretion?
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increase flow results in higher levels of bicarbonate in the secretion
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what is the best test to diagnose the cause of azotemia?
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fractional excretion of sodium FeNa
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how is the fractional excretion of sodium calculated?
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Urine sodium/creatinine divided by plasma sodium/creatinine
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what is the FeNa in prerenal azotemia?
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less than 1%
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why is myoglobin toxic to renal cells?
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Myoglobin gets converted to Ferrihemate in acidic environments, which in turn is toxic to renal cells
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which electrolyte decreases in tumor lysis syndrome?
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Calcium
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what is the treatment for tumor lysis syndrome?
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IV fluids to dilute, allopurinol to decrease further uric acid production, and diuretics to decrease potassium and phosphorus
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where does the synthesis of vitamin D in the body begin?
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The skin, from UV sunlight to form 7-dehydro cholesterol. Subsequently gets 25 – OH in liver, followed by 1 – OH in kidneys
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what is the initial treatment of hyperkalemia?
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Calcium gluconate to stabilize the heart
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what is the characteristic EKG finding of hyperkalemia?
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Peaked T-wave
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what are the EKG findings of hypokalemia?
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T-wave depression, U-wave, ST depression, and QT prolongation
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hypokalemia that is refractory to replacement can be due to deficiency in which other electrolyte?
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Magnesium
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what is the initial treatment for hyponatremia?
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Water restriction
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what is the effect of aggressive hyponatremia correction?
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Central pontine myelinosis
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how is sodium deficit calculated?
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0.6 x kg x (140-Na)
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what is the most common malignant cause of hypercalcemia?
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breast cancer
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which diuretics should be avoided in hypercalcemia?
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Thiazides, since they promote calcium reabsorption
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how does magnesium affect calcium levels?
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Magnesium is required for PTH function. Hypomagnesemia therefore results in hypocalcemia
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what is the EKG finding in hypocalcemia?
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QT prolongation
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what is the effect of hypoalbuminemia on calcium levels?
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Each 1 g drop in serum albumin decreases the measured calcium by 0.8
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what is the Henderson Hesselbach equation?
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pH=pK + log [HCO3/CO2]
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patient status post parathyroidectomy, POD7 develops perioral tingling and numbness, and notices twitching of face... Diagnosis? Tx?
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hypocalcemia from bone hunger, treatment is calcium
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what is the most common cause of significant hypo-phosphatemia?
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Re-feeding syndrome
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what is the most common cause of significant hypocalcemia?
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Previous thyroid surgery
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what is the most common cause of significant hypo-magnesemia?
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Massive diuresis
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what is the most common cause of significant hypokalemia?
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Over diuresis
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patient with severe pancreatitis and hyperlipidemia has a sodium of 125... Diagnosis? Tx?
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Pseudo-hyponatremia as a result of hyperlipidemia associated with pancreatitis elevated lipids draw fluid into the intravascular compartment no specific treatment -treat underlying disorder
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what is the composition of lactated ringers?
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Sodium 130, chloride 109, K four, calcium 2.7, HCO3 28
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a ventilated patient has the following ABG: pH 7.5, CO2 55, HCO3 35 this condition is most likely caused by A. poor minute ventilation, B. aggressive NG tube suctioning, C. renal failure, D. severe sepsis
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the ABG suggests a metabolic alkalosis therefore B. NG tube
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ventilated patient with ABG of: pH 7.5, CO2 24, HCO3 18 this condition is most likely caused by low or high minute ventilation, NG tube, or renal failure
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ABG suggests a respiratory alkalosis and a high minute ventilation is the most likely cause
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ABG of pH 7.25, CO2 70, HCO3 35 this condition is most likely caused by
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ABG respiratory acidosis, most likely caused by poor minute ventilation
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ABG values of pH 7.26, CO2 28 HCO3 18, this condition is most likely caused by..
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ABG is most consistent with metabolic acidosis of the options renal failure is most likely to give you a metabolic acidosis
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what is the initial treatment of choice for hyperkalemia with arrhythmias after succinylcholine?
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Calcium gluconate to stabilize cardiac muscle cell membranes
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what electrolyte abnormalities are seen in re-feeding syndrome? And how is it prevented?
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low K, Mg, and PO4, it is prevented by starting nutrition at a low rate initially (10 – 15 kcal per kilogram per day)
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which electrolyte abnormality can cause prolonged ventilation?
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hyperphosphatemia can result in prolonged ventilation due to relative ATP insufficiency
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what is the initial fluid of choice for dehydration due to small bowel fistula?
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Lactated ringers
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what is the initial fluid of choice for dehydration due to sweat loss?
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Normal saline
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what is the initial fluid of choice for dehydration due to large bowel fistula?
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lactated ringers
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what is the initial fluid of choice for dehydration due to gastric losses from pyloric stenosis?
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normal saline
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DKA results in what electrolyte abnormality?
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Hyperkalemia
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what is the best indicator of adequate volume replacement?
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Urine output
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what is the rule to calculate maintenance IVF?
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421
4 mL per kilogram per hour for the first 10 kg, 2 mL per kilogram per hour for the second 10 kg, 1 mL per kilogram per hour for each kilogram after that (first 20 kg equals 60 mL +1 mL for every kilogram after that) |
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what fluid do you never bolus?
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Normal saline with potassium added can cause cardiac arrest
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what is the most common cause of hypernatremia? treatment?
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Poor fluid intake 95%, D5 water , correct slowly to avoid brain swelling (less than 0.7 mEq per liter per hour)
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at what rate can you correct hyponatremia?
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Slowly to avoid central pontine myelinolysis ( less than 0.5 mEq per liter per hour)
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what is the most common cause of hyperkalemia? Tx?
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Renal disease 80%, Tx: 1. calcium gluconate 1 amp
2. 10 units of insulin and one ampule of 50% dextrose 3. 1 amp sodium bicarbonate 4. Kayexalate, lasix, albuterol, and dialysis if refractory |
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what is the most common cause of hypokalemia?Tx?
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diuretics, Tx: potassium chloride every 10 mEq increase serum potassium by 0.1 mEq per liter
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what is the most common malignant cause of hypercalcemia?
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Small cell lung cancer
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what is the most common cause of hypercalcemia crisis?
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Previous primary hyperparathyroidism undergoing another procedure
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what levels of calcium are dangerous? And what is the treatment for hypercalcemia crisis?
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calcium greater than 13 mg/dL or ionized greater than six causes symptoms, calcium greater than 15 mg/dL or an ionized greater than seven has a risk for cardiac arrest
Tx: 1. Rapid volume infusion NS no LR 2. Lasix, no thiazides 3. Dialysis if refractory 4. If malignancy bisphosphonates (alendronate) 5. if hyperparathyroidism -parathyroidectomy |
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what is Trousseau's sign?
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carpopedal spasm after occluding arm blood flow seen with hypocalcemia, calcium less than eight ionized less than four
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