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70 Cards in this Set

  • Front
  • Back
how much of the total body water is intracellular?
Two thirds, 2/3
in which cell is most of the bodies intracellular water?
Muscle
what is the most common cause of volume overload?
Iatrogenic
what is responsible for the plasma interstitial osmotic pressure gradient?
Proteins, mainly albumin
what is responsible for the intracellular – extracellular pressure gradient?
Sodium
how many mEq of sodium and chloride does a liter of 0.9% normal saline contain?
154 mEq of each
what are all the electrolytes in lactated ringers? And mEq of each?
sodium 130, chloride 109, lactate 28, potassium 4, calcium 3
how is plasma osmolarity calculated?
(2Na) x (Glucose/18) x (BUN/2.8)
how is free water deficits calculated?
0.6 x kg x [(Na/140) -1]
what drop in measured sodium does each 100 mg/dL rise in glucose cause?
3 mEq/L drop in measured sodium for every 100 mg/dL rise in glucose
what is the effect of acidosis on serum calcium?
Acidosis promotes calcium disassociation from albumin. Acidosis therefore causes increased free/ionized calcium
how much fluid is lost to evaporation and open abnormal cases?
Up to 1 L per hour
how much fluid is lost to insensible fluid losses? (sweat, respiration, etc.)
up to 10 mL per kilogram per day
what is the benefit to switching to dextrose containing IV fluids after G.I. surgery?
Dextrose will stimulate insulin release, enhance amino acid uptake and protein synthesis which will prevent catabolism
how many grams of dextrose does a liter of D5W contain?
50 g
how much fluid is secreted by the stomach per day?
1 to 2 L per day
how much food is secreted by each of pancreas, duodenum, and biliary system?
Each produce up to 1 L per day
what are daily and potassium requirements?
1 mEq per kilogram per day
which body fluid has the highest concentration of potassium?
Saliva
what effect does increase flow have on pancreatic/biliary secretion?
increase flow results in higher levels of bicarbonate in the secretion
what is the best test to diagnose the cause of azotemia?
fractional excretion of sodium FeNa
how is the fractional excretion of sodium calculated?
Urine sodium/creatinine divided by plasma sodium/creatinine
what is the FeNa in prerenal azotemia?
less than 1%
why is myoglobin toxic to renal cells?
Myoglobin gets converted to Ferrihemate in acidic environments, which in turn is toxic to renal cells
which electrolyte decreases in tumor lysis syndrome?
Calcium
what is the treatment for tumor lysis syndrome?
IV fluids to dilute, allopurinol to decrease further uric acid production, and diuretics to decrease potassium and phosphorus
where does the synthesis of vitamin D in the body begin?
The skin, from UV sunlight to form 7-dehydro cholesterol. Subsequently gets 25 – OH in liver, followed by 1 – OH in kidneys
what is the initial treatment of hyperkalemia?
Calcium gluconate to stabilize the heart
what is the characteristic EKG finding of hyperkalemia?
Peaked T-wave
what are the EKG findings of hypokalemia?
T-wave depression, U-wave, ST depression, and QT prolongation
hypokalemia that is refractory to replacement can be due to deficiency in which other electrolyte?
Magnesium
what is the initial treatment for hyponatremia?
Water restriction
what is the effect of aggressive hyponatremia correction?
Central pontine myelinosis
how is sodium deficit calculated?
0.6 x kg x (140-Na)
what is the most common malignant cause of hypercalcemia?
breast cancer
which diuretics should be avoided in hypercalcemia?
Thiazides, since they promote calcium reabsorption
how does magnesium affect calcium levels?
Magnesium is required for PTH function. Hypomagnesemia therefore results in hypocalcemia
what is the EKG finding in hypocalcemia?
QT prolongation
what is the effect of hypoalbuminemia on calcium levels?
Each 1 g drop in serum albumin decreases the measured calcium by 0.8
what is the Henderson Hesselbach equation?
pH=pK + log [HCO3/CO2]
patient status post parathyroidectomy, POD7 develops perioral tingling and numbness, and notices twitching of face... Diagnosis? Tx?
hypocalcemia from bone hunger, treatment is calcium
what is the most common cause of significant hypo-phosphatemia?
Re-feeding syndrome
what is the most common cause of significant hypocalcemia?
Previous thyroid surgery
what is the most common cause of significant hypo-magnesemia?
Massive diuresis
what is the most common cause of significant hypokalemia?
Over diuresis
patient with severe pancreatitis and hyperlipidemia has a sodium of 125... Diagnosis? Tx?
Pseudo-hyponatremia as a result of hyperlipidemia associated with pancreatitis elevated lipids draw fluid into the intravascular compartment no specific treatment -treat underlying disorder
what is the composition of lactated ringers?
Sodium 130, chloride 109, K four, calcium 2.7, HCO3 28
a ventilated patient has the following ABG: pH 7.5, CO2 55, HCO3 35 this condition is most likely caused by A. poor minute ventilation, B. aggressive NG tube suctioning, C. renal failure, D. severe sepsis
the ABG suggests a metabolic alkalosis therefore B. NG tube
ventilated patient with ABG of: pH 7.5, CO2 24, HCO3 18 this condition is most likely caused by low or high minute ventilation, NG tube, or renal failure
ABG suggests a respiratory alkalosis and a high minute ventilation is the most likely cause
ABG of pH 7.25, CO2 70, HCO3 35 this condition is most likely caused by
ABG respiratory acidosis, most likely caused by poor minute ventilation
ABG values of pH 7.26, CO2 28 HCO3 18, this condition is most likely caused by..
ABG is most consistent with metabolic acidosis of the options renal failure is most likely to give you a metabolic acidosis
what is the initial treatment of choice for hyperkalemia with arrhythmias after succinylcholine?
Calcium gluconate to stabilize cardiac muscle cell membranes
what electrolyte abnormalities are seen in re-feeding syndrome? And how is it prevented?
low K, Mg, and PO4, it is prevented by starting nutrition at a low rate initially (10 – 15 kcal per kilogram per day)
which electrolyte abnormality can cause prolonged ventilation?
hyperphosphatemia can result in prolonged ventilation due to relative ATP insufficiency
what is the initial fluid of choice for dehydration due to small bowel fistula?
Lactated ringers
what is the initial fluid of choice for dehydration due to sweat loss?
Normal saline
what is the initial fluid of choice for dehydration due to large bowel fistula?
lactated ringers
what is the initial fluid of choice for dehydration due to gastric losses from pyloric stenosis?
normal saline
DKA results in what electrolyte abnormality?
Hyperkalemia
what is the best indicator of adequate volume replacement?
Urine output
what is the rule to calculate maintenance IVF?
421
4 mL per kilogram per hour for the first 10 kg, 2 mL per kilogram per hour for the second 10 kg, 1 mL per kilogram per hour for each kilogram after that (first 20 kg equals 60 mL +1 mL for every kilogram after that)
what fluid do you never bolus?
Normal saline with potassium added can cause cardiac arrest
what is the most common cause of hypernatremia? treatment?
Poor fluid intake 95%, D5 water , correct slowly to avoid brain swelling (less than 0.7 mEq per liter per hour)
at what rate can you correct hyponatremia?
Slowly to avoid central pontine myelinolysis ( less than 0.5 mEq per liter per hour)
what is the most common cause of hyperkalemia? Tx?
Renal disease 80%, Tx: 1. calcium gluconate 1 amp
2. 10 units of insulin and one ampule of 50% dextrose
3. 1 amp sodium bicarbonate
4. Kayexalate,
lasix, albuterol, and dialysis if refractory
what is the most common cause of hypokalemia?Tx?
diuretics, Tx: potassium chloride every 10 mEq increase serum potassium by 0.1 mEq per liter
what is the most common malignant cause of hypercalcemia?
Small cell lung cancer
what is the most common cause of hypercalcemia crisis?
Previous primary hyperparathyroidism undergoing another procedure
what levels of calcium are dangerous? And what is the treatment for hypercalcemia crisis?
calcium greater than 13 mg/dL or ionized greater than six causes symptoms, calcium greater than 15 mg/dL or an ionized greater than seven has a risk for cardiac arrest
Tx: 1. Rapid volume infusion NS no LR 2. Lasix, no thiazides 3. Dialysis if refractory 4. If malignancy bisphosphonates (alendronate) 5. if hyperparathyroidism -parathyroidectomy
what is Trousseau's sign?
carpopedal spasm after occluding arm blood flow seen with hypocalcemia, calcium less than eight ionized less than four