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14 Cards in this Set
- Front
- Back
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What is gene translocation? What is the clinical significance?
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Movement of a gene fragment from one chromosomal location to
another May alter or abolish gene expression |
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What are the two methods by which translocations are identified?
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Polymerase chain reaction (PCR)
Fluorescence in situ |
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PCR is used for the amplification what?
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DNA
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Real-time PCR is used for the amplification of what?
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RNA
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What translocation is associated with Ewing sarcoma?
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11:22
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What translocation is associated with myxoid liposarcoma?
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12:16
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What translocation is associated with clear cell sarcoma?
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12:22
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What translocation is associated with synovial sarcoma?
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X:18
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What translocation is associated with rhabdomyosarcoma?
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2:13
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What translocation is associated with myxoid chondrosarcoma?
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9:22
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What gene is associated with osteosarcoma and retinoblastoma?
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Rb1
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With what syndrome is a p53 mutation associated?
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Li-Fraumeni
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What is the inheritance pattern of this genetic mutation?
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Autosomal dominant (AD)
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What four other classes of tumors have been associated with p53 mutations?
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Adrenal tumors
Brain tumors Soft tissue sarcomas (e.g., rhabdomyosarcoma) Breast cancer |
