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23 Cards in this Set
- Front
- Back
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How many CDRs are in the alpha chain of the TCR
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3 CDRs
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How many CDRs are in the beta chain of the TCR
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3 CDRs for binding (paired with alpha chains) and a 4th Vbeta region participating in superantigen binding
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Which chain of the TCR, alpha or beta, has VDJ recombination?
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B chain
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Which chain of the TCR, alpha or beta, has VJ recombination?
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a chain
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How many Ig Domains are in each chain of the TCR
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each chain has one V and one C domain
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What are the associated signaling molecules of the TCR's alpha and beta chain
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Zeta chain (CD-2478) and CD3
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What are the component chains of the CD3 molecules?
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one delta, two epsilon, one gamma
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What is the activating receptor on natural killer cells (ITAM on NK cells)
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NKG2D is activating
(NKG2A is inhibiting) |
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Does the gamma-delta TCR associate with CD3 or CD247?
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Yes, the TCR chains are gamma-delta and not alpha-beta, otherwise the CD3 and zeta chain are the same
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What do the majority of gamma-delta TCRs express: Cd4, CD8, both or neither?
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Neither
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What is the approximate percentage of gamma-delta TCRs in humans?
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<5% of all TCRS (but about 10% of intestinal intraepithelial lymphocytes are gamma-delta TCR
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What receptor do all NK-T cells use (CD marker) and what molecule this receptor allow NK-T cells to recognize
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NKT uses CD1, which enables them to recognize lipids
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What cytokines are NK-T cells rapidly able to synthesize in response to activation
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Activation of CD-1 by lipids enables rapid production of IL-4 and IFN-gamma
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CD marker for ICAM-1
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CD-54
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CD marker for LFA-1
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CD 11a / CD18
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Receptor for ICAM-1
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LFA-1
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Receptor for LFA3?
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CD-2
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CD marker of LFA-3?
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CD-58
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Approximate percentage of CD4 : CD8 T cells in body?
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2:1 (or 65% CD4 and 35% CD8)
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Receptor for SLAM?
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SLAM (CD-150) is its own receptor
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CD-150 deficiency is associated with what infection (and what is the eponym of the immunodeficiency)
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EBV infection
Duncan's disease (sorry, bad question) |
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CD marker for FAS
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CD-95
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CD marker for FAS-ligand
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CD-178
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