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22 Cards in this Set

  • Front
  • Back
These early researchers discovered the nature passive transfer of antibodies, allowing life threatening Diptheria to be treated by serum from immunizided horses
Von Vehring and Kitasato in 1890
Which isoform of FcyRII is inhibitory?
Isoform B is inhibitory

(isoform A is activating)
This type of antigen binding molecule is able to accept both linear and conformational determinants
Antibodies (Ig)

T cell receptors only linear
CD marker / Fc receptor found on neutrophils
FcyRI, high affinity, CD64
CD marker / Fc receptor found on NK cells
FcyRIII, low affinity, CD16
Place, in rank order, serum concentrations of Ig
G-A-M-E-D
Which IgG subclass has the shortest halflife?
IgG3
Who discovered monoclonal antibodies through use of hybridomas?
Kohler and Milstein (1975)
Which CDR region is the most variable?
CDR3
Which peptase breaks an antibody into two fragments: Fab (x2) and Fc
Papain
Which peptidase breaks an immunoglobulin into an F(ab')2 only?
Pepsin
Which Igs contain 3 C regions?
G - A - D
Which Igs contain 4 C regions?
M - E

(Kim said the phrase "I want more... ME = more")
Which Ig has the shortest half-life?
IgE of 2 days (although IgD has half-life of 3 days)
Which Ig has the longest half-life
IgG at 23 days
Which Ig has the largest serum concentration?
IgG at 13.5 mg/ml
What are the CD markers for the Iga and IgB of the BCR?
CD-79a and CD-79b
What is polyvalency
Multiple identical determinants in an antigen is referred to as polyvalency or multivalency
What is done to small immunogens that are not capable of stimulating a humoral response on their own accord? (small chemicals, for example)
Bind the small chemical, called a hapten, with a protein, called a carrier. This makes the hapten-carrier complex capable of acting like an immunogen
What are the three major types of determinants?
Conformational, linear and neoantigenic (the final one caused by proteolysis)
What is the difference between affinity and avidity?
Affinity = strength of a single binding site between antibody and epitope

Avidity is strength of entire antibody molecule combining to all epitopes (IgM has higher avidity due to 5 binding sites, for example)
What is the only way for an antibody to increase its affinity?
Affinity maturation increases affinity. No other way.