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15 Cards in this Set
- Front
- Back
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what causes neutropenia, cytopenia?
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indomethacin
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the sulfide metabolite is the most potent form of which prodrug?
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sulindac
sulfoxide --> sulfide metabolite (500x more active) |
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What is used for closure of DA?
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indomethacin
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what is a feature of etodolac?
and a use? |
less GI toxicity (than tolmetin, ketorolac, diclofenac)
post op pain |
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does etodolac inhibit COX2 or COX1 more?
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COX2 - 10fold
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what is ketorolac used for?
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post-op pain***
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what is diclofenac combo'ed with?
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arthrotec = misoprostol + diclofenac
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effects of propionic acid derivatives on platelet function and leukocyte function? (vs. APAP)
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dec. platelet function
dec. leukocyte function |
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meloxicam
effect on platelet function vs. piroxicam? |
less effect on platelet function
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piroxicam...
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GI toxicity (P>M)
dec. excretion of lithium, inc. lithium t 1/2 |
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nabumetone's metabolite?
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6MNA
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benefit of using rofecoxib or celecoxib as compared to other NSAIDS?
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dec. GI toxicity
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once daily dosing?
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oxaprozin
meloxicam piroxicdam nabumetone |
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what did rofecoxib & celecoxib increase?
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inc. stroke, CV problems, heart attacks
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avoid celecoxib if have what allergy?
other use of celecoxib? |
sulfonamide allergy
dec. incidence of colon polyps (for FAP) |
