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15 Cards in this Set

  • Front
  • Back
what causes neutropenia, cytopenia?
indomethacin
the sulfide metabolite is the most potent form of which prodrug?
sulindac
sulfoxide --> sulfide metabolite (500x more active)
What is used for closure of DA?
indomethacin
what is a feature of etodolac?
and a use?
less GI toxicity (than tolmetin, ketorolac, diclofenac)
post op pain
does etodolac inhibit COX2 or COX1 more?
COX2 - 10fold
what is ketorolac used for?
post-op pain***
what is diclofenac combo'ed with?
arthrotec = misoprostol + diclofenac
effects of propionic acid derivatives on platelet function and leukocyte function? (vs. APAP)
dec. platelet function
dec. leukocyte function
meloxicam
effect on platelet function vs. piroxicam?
less effect on platelet function
piroxicam...
GI toxicity (P>M)
dec. excretion of lithium, inc. lithium t 1/2
nabumetone's metabolite?
6MNA
benefit of using rofecoxib or celecoxib as compared to other NSAIDS?
dec. GI toxicity
once daily dosing?
oxaprozin
meloxicam
piroxicdam
nabumetone
what did rofecoxib & celecoxib increase?
inc. stroke, CV problems, heart attacks
avoid celecoxib if have what allergy?

other use of celecoxib?
sulfonamide allergy

dec. incidence of colon polyps (for FAP)