Aaa Lipid Lowering Agents

Front 1

reduce LDL levels

Back 1

lovastatin, pravastatin, simvastatin, atorvastatin, fluvastatin, rosuvastatin, cholestyramine, colestipol, olesevelam, ezetimibe

Front 2

decrease VLDL, increase L Lipase activity, decrease tryglycerides)

Back 2

fenofibrate, gemfibrozil

Front 3

decrease VLDL, LDL, and LP a, increase HDL (decrease TG and CE)

Back 3

niacin, nicotinic acid, vit B3

Front 4

use in hypercholerstolemia, hyperlipoprotenemia, and ischemic stroke prophyaxis or when reduction of LDL needed

Back 4

lovastatin, pravastatin, simvastatin, atorvastatin, fluvastatin, rosuvastatin

Front 5

used for hypercholesterolemia and hyperlipoprotenemia

Back 5

cholestyramine, colestipol, colesevelam, ezetimibe

Front 6

used in hypertryclyceridemia, combined hyperlipoprotemiia, adjunctive therapy for hypercholesteroemia

Back 6

fenofibrate, gemfibrozil, niacin, nicotinic acid, vit B3

Front 7

MOA of statins

Back 7

inhibits hmg-coa, reduces synthesis of liver cholesterol, upregulation of ldl receptors in liver

Front 8

MOA of cholestyramine, colestipol, colesevelam

Back 8

anion exchange resin binds bile acids, prevents bile acid and cholesterol reabsorption

Front 9

MOA of ezetimibe

Back 9

inhibits NPC1L1 cholesterol transport in gut, prevents absorption of cholesterol

Front 10

MOA of fibrates

Back 10

ligand for nuclear transcription receptor, peroxisome proliferator activated receptor alpha

Front 11

MOA of niacin, nicotinic acid, vit B3

Back 11

Dec FFA to liver

Front 12

what are the cyp 3a4 lipid lowering agents

Back 12

lovastatin, simvastatin, atorvastatin

Front 13

what lipid lowering agents cross placenta

Back 13

fenofibrate, gemfibrozil

Front 14

Tox of statins

Back 14

liver, elevated aminotransferase, muscle elevated creatine kinase, myopathy, rhabdomylosis, neuropathry, hypersensitivity

Front 15

Tox of cholestyramine, colestipol, colesevelam

Back 15

constipation, bloating, GI distress, malabsorption of vitamins, elevated aminotransferase and serum triglycerides, hypercholerimc acidosis in children and liver failure

Front 16

tox of ezetimibe

Back 16

reversible impaired hepatic fx, myositis

Front 17

tox of fibrates

Back 17

rash gi upset, ED, myositis, potentiates, oral anticoagulant effects, increased serum aminotransferase, increased gallstones

Front 18

tox of niacin

Back 18

warm flushes (red with NSAID) skin rashes, gi upset, elevated liver transferase hepatotox, carb intolerance, hyperuricemia, arrhythmias

Front 19

contraindications of statins

Back 19

chronic or active liver disease

Front 20

contraindications of sterol absorption inhibitors

Back 20

dysbetalipoproteinemia or TG>400

Front 21

contraindications of fibrates

Back 21

kidney, liver or biliary disease

Front 22

contraindication of niacin

Back 22

acanthosis, nigricans, diabetes, peptic disease, gi ulcer, chronic liver disease, gout

Front 23

reduce LDL levels

Back 23

lovastatin, pravastatin, simvastatin, atorvastatin, fluvastatin, rosuvastatin, cholestyramine, colestipol, olesevelam, ezetimibe

Front 24

decrease VLDL, increase L Lipase activity, decrease tryglycerides)

Back 24

fenofibrate, gemfibrozil

Front 25

decrease VLDL, LDL, and LP a, increase HDL (decrease TG and CE)

Back 25

niacin, nicotinic acid, vit B3

Front 26

use in hypercholerstolemia, hyperlipoprotenemia, and ischemic stroke prophyaxis or when reduction of LDL needed

Back 26

lovastatin, pravastatin, simvastatin, atorvastatin, fluvastatin, rosuvastatin

Front 27

used for hypercholesterolemia and hyperlipoprotenemia

Back 27

cholestyramine, colestipol, colesevelam, ezetimibe

Front 28

used in hypertryclyceridemia, combined hyperlipoprotemiia, adjunctive therapy for hypercholesteroemia

Back 28

fenofibrate, gemfibrozil, niacin, nicotinic acid, vit B3

Front 29

MOA of statins

Back 29

inhibits hmg-coa, reduces synthesis of liver cholesterol, upregulation of ldl receptors in liver

Front 30

MOA of cholestyramine, colestipol, colesevelam

Back 30

anion exchange resin binds bile acids, prevents bile acid and cholesterol reabsorption

Front 31

MOA of ezetimibe

Back 31

inhibits NPC1L1 cholesterol transport in gut, prevents absorption of cholesterol

Front 32

MOA of fibrates

Back 32

ligand for nuclear transcription receptor, peroxisome proliferator activated receptor alpha

Front 33

MOA of niacin, nicotinic acid, vit B3

Back 33

Dec FFA to liver

Front 34

what are the cyp 3a4 lipid lowering agents

Back 34

lovastatin, simvastatin, atorvastatin

Front 35

what lipid lowering agents cross placenta

Back 35

fenofibrate, gemfibrozil

Front 36

Tox of statins

Back 36

liver, elevated aminotransferase, muscle elevated creatine kinase, myopathy, rhabdomylosis, neuropathry, hypersensitivity

Front 37

Tox of cholestyramine, colestipol, colesevelam

Back 37

constipation, bloating, GI distress, malabsorption of vitamins, elevated aminotransferase and serum triglycerides, hypercholerimc acidosis in children and liver failure

Front 38

tox of ezetimibe

Back 38

reversible impaired hepatic fx, myositis

Front 39

tox of fibrates

Back 39

rash gi upset, ED, myositis, potentiates, oral anticoagulant effects, increased serum aminotransferase, increased gallstones

Front 40

tox of niacin

Back 40

warm flushes (red with NSAID) skin rashes, gi upset, elevated liver transferase hepatotox, carb intolerance, hyperuricemia, arrhythmias

Front 41

contraindications of statins

Back 41

chronic or active liver disease

Front 42

contraindications of sterol absorption inhibitors

Back 42

dysbetalipoproteinemia or TG>400

Front 43

contraindications of fibrates

Back 43

kidney, liver or biliary disease

Front 44

contraindication of niacin

Back 44

acanthosis, nigricans, diabetes, peptic disease, gi ulcer, chronic liver disease, gout