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20 Cards in this Set

  • Front
  • Back
DDx of Baker's cyst
DVT (always consider)
popliteral artery aneurysm
lymphadenopathy
tumor
If Osgood-Schlatter does not remit with rest, what is the next step?
steroids
What are the calcium phosphate and alk phos levels in osteoporosis?
all normal!
What are the calcium phosphate and alk phos levels in osteomalacia?
low calcium
low phosphorous (PTH activated)
high alk phos (leeching)
What are the calcium phosphate and alk phos levels in Paget's?
calcium and phosphorous are NORMAL, but alk phos is very high
What are the calcium phosphate and alk phos levels in renal osteodystrophy?
calcium is low (why?)
phosphorous is HIGH (can't excrete)
alk phos is high
What are the calcium phosphate and alk phos levels in hyperparathryroidism?
calcium is high (leeching)
phosphorous is low (PTH activated, excreting P)
alk phos is high
Which metabolic bone disorders have normal calcium and phosphorous?

Which have normal alk phos?
osteoporosis
Paget's (only alk phos elevated)

osteoporosis (all labs normal)
Paget's affects the [axial, appendicular] skeleton more
axial
In addition to multiple myeloma, what bone dz has lytic lesions on skull xray?
Paget's
What are diagnostic/imaging markers for Paget's
1. Bone scan > xray
2. urine hydroxyproline
3. 24 hour urine N-telopeptide
Paget's has potential for malignant transformation, especially in ? and ?
humerus and femur
Treatment for Paget's
bisphosphonates
calcitonin analogs
What end-organ problem (besides bon) can Paget's cause?
high output cardiac failure
Palpable purpura:
how are they distinguished clinically
what are they pathognomonic for
they do not blanch, b/c they are not vascular
pathogn. of vasculitis
What are the 3 hypersensitivity vasculitides?
cryoglobulinemia
Henoch-Schonlein purpura
serum sickness
What are the two main clinical signs of hypersensitivity vasculitis?
1. palpable purpura
2. neutrophils in perivascular space on biopsy ("leukocytoclastic") -- but this is also seen in endocarditis, EBV, HIV, hepatitis, ulcerative colitis, PBC.
What happens to patients with cryoglobulinemia when they get cold?
they get palpable purpura
Monoclonal cryoglobulinemia is associated with what disorders?
Multiple myeloma
Waldenstrom's
lymphoma
leukemia
Symptoms of monoclonal cryoglobulinemia (MM, Waldenstrom)?
hyperviscosity symptoms:

headaches
blurry vision
EPISTAXIS
Raynaud's
ISCHEMIC ULCERS, skin necrosis