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12 Cards in this Set

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Radiation Oncology

Five possible modes of interaction of photons with matter:
1. coherent scattering
2. photoelectric absorption
3. compton scattering
4. pair production
5. photo-nuclear disintegration
Radiation Oncology - Pharm

What two rays are predominately used int electromagnetic radiation?
X-rays and gamma rays
Radiation Oncology - Pharm

What are three long term effects of radiation?
1. carcinogenicity
2. hereditary effects
3. teratogenic effects (dose to embryo)
Radiation Oncology - Pharm

How are gamma and x-rays produced?
Gamma: decay of radioactive materials

X-ray: produced by electrical machines
Radiation Oncology - Pharm

What is the range of x-ray for diagnosis and therapy?
Diagnosis: 10-200KV

Therapy: >200KV
Radiation Oncology - Pharm

What is the advantage of megavoltage radiation?
Megavoltage radiation
1. skin sparing
2. increased depth dose
3. less side scatter and sharper beam edge
4. predominance of comptom interactions
Radiation Oncology - Pharm

What are three advantages of electron beam RT?
Electron beam RT:
1. useful in skin and superficial lesions
2. uniform dose from surface to depth
3. dose falls off rapidly
Radiation Oncology - Pharm

What is the target of radiation?
DNA
Radiation Oncology - Pharm

What is the process of interaction of radiation with the body?
Incident photon --> fast electron --> free radical --> chemical change --> biological effect
Radiation Oncology - Pharm

What is the oxygen effect?
Oxygen effect

The level of cell killing by photons is dependant on the cellular oxygen tension at the time of radiation

Oxygen enhances the cell killing effect of radiation.
Radiation Oncology

What are the differences between the two radiation techniques: Brachytherapy & Teletherapy
Brachytherapy: radiation device is placed very close to or within target tissue

Teletherapy: device is located at a distance from the patinet
Radiation Oncology

What is one benefit of have two strand breaks in DNA being far apart?
Between those two breaks there is a bunch of base damage.