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44 Cards in this Set
- Front
- Back
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Acronym for Serotonin drugs?
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Little boys scare fat people sitting calmly on airplanes
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Agonists of Serotonin receptors
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Little boys scare
-LSD -Buspirone -Sumatriptan |
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What receptor does LSD hit?
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5HT2
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What effect does LSD have?
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-Potent hallucinogen especially visual
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Is LSD a full or partial agonist of the 5HT2 receptor?
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Yes
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What receptor does Buspirone hit?
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5HT1a
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What type of agonist is Buspirone and what is its use?
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Partial agonist
-Antianxiety drug |
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What receptor does Sumatriptan hit?
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5HT1D
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What is the 5HT1D receptor responsible for?
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Vasoconstriction of pulm/renal and CNS vessels
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What is Sumatriptan prescribed for and what is its effect??
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Existing migraine headaches - stops vessels from pushing against foramen
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What are 5 side effects of Sumatriptan?
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Nausea, vomiting, angina, dizziness, and flushing
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What are 2 contraindications to Sumatriptan?
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Heart disease and pregnancy
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What is FPS? What type of drugs are they?
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Fat people sitting
-Indirect agonists |
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What is an indirect agonist?
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A drug that has no intrinsic activity at the receptor; it just increases Serotonin
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What are the 3 indirect serotonin agonists?
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Fat people sitting
-Fluoxetine -Phenelzine -Sibutramine |
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What is Fluoxetine?
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An SSRI
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What is the effect of a selective serotonin reuptake inhibitor?
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More serotonin in the synapse
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What is Fluoxetine used to treat?
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-Depression
-OCD -Panic attacks |
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What are 2 side effects of Fluoxetine?
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-Sexual dysfunction
-Nausea |
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What is the P in FPS?
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Phenelzine
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What is the mechanism of action of Phenelzine?
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MAOI - inhibits monoamine oxidase
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What does inhibiting MAO do to serotonin?
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Blocks its metabolism so it stays around in the synapse longer
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What 2 things is Phenelzine used to treat?
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-Depression
-Narcolepsy |
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When MAO is inhibited by Phenelzine, does it only prevent metabolism of Serotonin?
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No - it is not specific so it has many side effects
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What is a bad side effect of MAOIs?
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Hypertensive crisis if the person eats cheese, sausage, wine, or beer.
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What is in cheese/ssg/wine/beer?
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Tyramine (Tyra banks is mine not yours and she is found in sausage and beer)
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What is the S in Fat people sitting?
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Sibutramine
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What is the mechanism of Sibutramine?
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Blocks the uptake of
-Serotonin -Norepinephrine -Dopamine |
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What is Sibutramine used to treat?
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Obesity
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How is Sibutramine thought to treat obesity?
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By enhancing satiety via Serotonin, and increasing the metabolic rate via NE
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Does Sibutramine work?
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no
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What is calmly on airplaines?
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The Serotonin Antagonists!!
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What are the serotonin antagonists?
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-Cyproheptadine
-Ondansetron -Alosetron |
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What receptors is Cyproheptadine an antagonist of?
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5HT2 and H1 (histamine)
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What 2 conditions is Cyproheptadine used for treating?
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-Skin allergies (pruritis and urticaria)
-Carcinoid |
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What receptor is Ondansetron an antagonist of?
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5HT3
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Where is 5HT3 and what does it mediate? What type of receptor?
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-In CNS and gut
-Mediates vomiting and nausea -Ligand gated ion channel |
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What is Ondansetron used to treat?
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Chemotherapy induced nausea and vomiting
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What receptor is Alosetron an antagonist of?
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5HT3
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What is Alosetron used to treat?
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Unhappy bellies - IBS with DIARRHEA in women
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Why is Alosetron restricted in its availability for prescription?
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It can cause severe adverse GI effects
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What is Serotonin further converted to in the pineal gland?
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Melatonin
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What Gi protein is coupled to the Melatonin receptor?
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Gi
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What does Melatonin do?
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Entrains the circadian clock
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