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9 Cards in this Set
- Front
- Back
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What are the 2 starting structures for purine synthesis?
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Sugar + phosphate
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What do you add to make a purine?
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Base
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What inhibits purine synthesis?
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6-mercaptopurine
6MP |
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What is the starting structure for Pyrimidine synthesis?
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Temporary base (orotic acid)
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What do you add to Orotic acid?
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Sugar and Phosphate (PRPP)
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What happens after you add sugar and phosphate?
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Modify the base
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What does Hydroxyurea inhibit?
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Ribonucleotide reductase, which converts UDP to dUDP
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What does 5-flourouracil inhibit?
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Thymidylate synthase, which converts dUMP to dTMP
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What does MTX/TMP inhibit?
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Dihydrofolate reductase, which converts DHF to THF, allowing the continued conversion of dUMP to dTMP
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