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33 Cards in this Set
- Front
- Back
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What are the 2 muscarinic agonists?
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-Bethanechol
-Pilocarpine |
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What is the acronym for ACh esterase inhibitors?
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ESPN PE
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What is ESPN PE?
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-Edrophonium
-Sarin -Physostigmine -Neostigmine -Parathion -Echothiophate |
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Acetylcholine activator
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Pralidoxime
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Ganglionic blocker
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Trimethaphan
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Muscarinic receptor antagonists:
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ASI
-Atropine -Scopalamine -Ipratropium |
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What are the neuromuscular cholinergic blocking agents? (acronym)
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VAMPS
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What is VAMPS?
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-Vecuronium
-Atracurium -Mivacurium -Pancuronium -Succinylcholine |
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What is the difference between VAMP and S?
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VAMP = nondepolarizing (antagonist)
S = depolarizing (agonist) |
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What are the 4 big things that happen when Muscarinic receptors are activated?
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SLUD
-Salivation -Lacrimation -Urination -Defecation |
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How will activating muscarinic receptors effect the eye?
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-Contract ciliary m; accommodate
-Contract iris sphincter; miosis |
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How will activating muscarinic receptors effect the heart?
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Decrease heartrate
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How will activating muscarinic receptors effect the lung?
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-Constrict bronchi
-Increase secretions |
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How will activating muscarinic receptors effect the bladder?
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Increase voiding
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How will activating muscarinic receptors effect the GI tract?
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-Increase salivation
-Increase gastric secretions -Increase intestinal tone and motility |
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How will activating muscarinic receptors effect sweat glands?
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increase sweating via SNS stimulated ACh
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How will activating muscarinic receptors effect blood vessels??
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Vasodilation via NO release
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How will activating muscarinic receptors effect male sex organs?
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Erection (Point)
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Where are all cholinergic muscarinic receptors?
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Parasympathetic neuroeffector junctions
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Where are cholinergic nicotinic receptors? (3 sites)
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-Neuromuscular junctions
-Neuroneuronal junctions (ganglionic and adrenal medulla) -NeuroCNS (brain and spinal cord) |
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Effect of ACh at the neuromuscular junction?
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EPP - skeletal mm contraction
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Effect of ACh at Nn junctions
-Autonomic ganglia -Adrenal medulla |
Ganglionic - postganglionic neurons fire
Adrenal medulla - secrete Epi/NE |
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Effect of ACh at N-CNS junctions:
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Control the amount of parasympathetic outflow - NT release
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What are the 2 main clinical uses of Muscarinic Agonists?
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-Glaucoma
-Adynamic GI tract, urinary retention |
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What are Muscarinic Antagonists used to treat in the CNS? (2 things)
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-Motion sickness
-Parkinson's disease |
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What are Muscarinic Antagonists used to treat in the heart?
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Bradyarrhythmias
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What are Muscarinic Antagonists used to treat in the respiratory system?
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-COPD
-ASTHMA |
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What 2 things are Muscarinic Antagonists used to treat in the eye?
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-Pupil dilation and cycloplegia for eye exam
-Cycloplegia for iritis |
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What 2 things are Muscarinic Antagonists used to treat in the GI and urinary tract?
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-Hypermotility and urinary incontinence
-Peptic ulcers |
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What are ACE inhibitors?
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Acetylcholinesterase inhibitors
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What are 5 main clinical uses of ACE inhibitors?
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-Glaucoma
-GI hypomotility/urinary incontinence -Myasthenia gravis -Tx of Muscarinic antagonist poisoning and TCAs -Alzheimer's disease |
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What are Ganglionic blocking agents given for?
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Hypertensive emergencies (blocks both SNS/PNS ganglionic synapses)
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What are NMJ blocking agents gven for?
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Skeletal muscle relaxation
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