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11 Cards in this Set
- Front
- Back
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What is the mechanism for Allopurinol?
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Inhibits Xanthine Oxidase, decreases conversion of Xanthine to uric acid
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When do you use Allopurinol?
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Chronic Gout
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What is the mechanism for Febuxostat?
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Inhibits Xanthine Oxidase
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What is the mechanism for Probenecid?
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Inhibits reabsorption of uric acid in PCT
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What is the mechanism for Cochicine?
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Binds and stabilizes tubulin to inhibit polymerization, impairing leukocyte chemotaxis and degranulation
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What is the major side effect of Colchicine?
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GI side effects
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What do all TNF-a inhibitors predispose the patient to?
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Infection, including reactivation of latent TB
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What is the mechanism for Etanercept?
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TNF decoy receptor
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What are the 3 uses for Etanercept?
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RA, psoriasis, Ankylosing spondylitis
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What is the mechanism for Infliximab, Adalimumab?
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Anti-TNF-a monoclonal antibody
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What are the 4 uses for Infliximab, Adalimumab?
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Crohn's disease, RA, Ankylosing spondylitis, psoriasis
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