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9 Cards in this Set
- Front
- Back
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What is endochondral ossification?
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Cartilaginous model of bone which is first made by chondrocytes (laminal bone)
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What locations have endochondral ossification?
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Axial and appendicular skeleton
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What is membranous ossification?
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Woven bone formed directly w/out cartilage
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What locations have membranous ossification?
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Bones of Calvarium and facial bones
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What do osteoblasts do?
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Build bone by secreting collagen and catalyzing mineralization
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What do osteoclasts do?
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Multinucleated cells that disolve bone by secreting acid and collagenases
Differentiate from monocytes/macrophages |
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What does PTH do in regards to bone?
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At low intermittent levels it exerts anabolic levels, exerts anabolic effect (builds bone) on osteoblasts and osteoclasts
Chronic high PTH levels cause catabolic effects (breaks bone) |
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What does estrogen do in regards to bone?
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Estrogen inhibits apoptosis in bone-forming osteoblasts and induces apoptosis in bone-resorbing osteoclasts
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What does low estrogen do to bone?
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Cause apoptosis to osteoblasts and doesn't induce apoptosis to osteoclasts, leading to bone loss and osteoporosis
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