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21 Cards in this Set
- Front
- Back
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What does an Oncogene mutation do?
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Gains function, leads to an increase in cancer risk
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What is the abl gene associated with?
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CML
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What is the c-myc gene associated with?
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Burkitt's Lymphoma
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What is the bcl-2 gene associated with?
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Follicular and undifferentiated lymphomas
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What is the HER2/neu gene associated with?
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Breast/ovarian/gastric carcinomas
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What is the ras gene associated with?
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Colon carcinomas
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What is the L-myc gene associated with?
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Lung tumor
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What is the N-myc gene associated with?
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Neuroblastoma
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What is the ret gene associated with?
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Multiple endocrine neoplasia (MEN2A and MEN2B)
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What is the c-kit gene associated with?
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GI stromal tumor
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What do tumor suppressor gene mutations do?
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Loses function, increases cancer risk
Both alleles must be lost for expression of the disease, but the loss of one greatly increases the chance of development of tumor |
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What is the Rb gene associated with?
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Retinoblastoma, osteosarcoma
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What is the p53 gene associated with?
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Most all cancers
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What are the BRCA1 and BRCA2 gene associated with?
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Breast and ovarian cancers
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What is the p16 gene associated with?
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Melanoma
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What is the BRAF gene associated with?
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Melanoma
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What is the APC gene associated with?
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Colorectal cancer
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What is the WT1 gene associated with?
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Wilm's Tumor (nephroblastoma)
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What are the NF1 and NF2 gene associated with?
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Neurofibromatosis types 1 and 2
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What is the DPC4 gene associated with?
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Pancreatic cancer
(Deleted in pancreatic cancer) |
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What is the DCC gene associated with?
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DCC
Deleted in colon cancer |
