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13 Cards in this Set
- Front
- Back
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Absorption - Laxatives
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Inc gastric empyting time, gastric motility, dec drug absorption
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Absorption - Narcotics
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Dec gastric emptying time
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Absorption - Antacids
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Inc gastric pH
Slows absorption of acid drugs |
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Absorption - Anticholingergics
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Dec gastric motility
Inc or dec drug absorption depending where the drug is delayed (gastric vs intestinal) |
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Absorption - Aspirin
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Dec gastric pH
Inc drug absorption |
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Absorption - Antacids and tetracycline
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Forms drug complexes
Blocks drug absorption |
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Distribution - Anticoagulant and anti-inflammatory (sulindac)
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Competes for protein-binding sites
Inc free drug eg inc anticoagulant |
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Metabolism or biotransformation - Barbiturates
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Promote induction of liver enzymes
Inc drug metabolism Dec drug plasma concentration of second drug |
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Metabolism or biotransformation - Antiulcer (cimetidine)
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Inhibit liver enzymes release
Dec drug metabolism of diazepam (Valium), phenytoin (Dilantin) morphine etc Inc drug plasma concentration of second drug |
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Excretion - Antidysrhythmic (quinidine)
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Dec renal excretion of second drug (eg digoxin)
Inc digoxin concentration |
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Excretion - Antigout (probenecid)
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Dec excretion of penicillin by competing for tubular reabsorption
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Excretion - Antacid (sodium bicarbonate)
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Promotes excretion of weak acid drug (eg aspirin, barbiturates, sulfonamides)
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Other: Dec CO and renal BF - Aspirin, ammonium, chloride
Most drug categories |
Promote excretion of weak base drugs (eg quinidine, theophylline)
Dec drug excretion Inc drug plasma concentration |
