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9 Cards in this Set
- Front
- Back
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GFAP Producers
CNS Infections Arachnoid Granulations |
Astrocytes
Secondary to other infections. Hematogenous spread Recycling CSF |
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Meningitis
What causes multinucleated giant cells? What causes abscesses and cerebritis? |
Primarily bacterial (lepto = pia, arachnoid...no brain parenchymal invasion)
Fungal and tuberculoid infections Primarily bacterias |
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What causes encephalitis?
Tropisms of HIV, polio, Herpes? What causes nuclear inclusions? |
Viruses.
Immune cells, motorneurons, temporal lobe Viruses...propogation IN nucleus (Negri body = rabies) |
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HIV predisposes to:
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Viruses: PML (from JC virus), Herpes, CMV
Bacteria: MAI, Toxoplasmosis, cryptococcal meningoencephalitis, Neoplasms: Kaposi's, primary lymphomas |
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PML traits:
Toxoplasmosis: |
JC virus, immunocompromised, demyelination of white matter.
Cysts, fungi-related. Giesma stain |
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Spongiform Encephalitis
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Look like spongy tissues. CJD or BSSE. 100% mortality. Dendrite swelling
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Causes of CJD
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85% sporadic...corneal transplants, neurosurgery to replace dura, hormone treatment. Can transplant from one patient to another (protein hypothesis)
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CJD specifics
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Mutations in PRNP (esp. codon 129...methionine and valine) Normal = alpha-helix. Intermediate. BAD = b-sheets
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Aspergillus
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Fungal infection. Asparagus! Holes in lung
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