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14 Cards in this Set

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  • Back
1. Diagram the lymph node anatomy and note the locations of B cells, T cells, macrophages, and plasma cells?

2. Diagram the spleen anatomy and note the locations of B cells, T cells, macrophages, and plasma cells?

3. Compare lymph drainage above and below the pectinate line?
1. SEE SHEET

2. SEE SHEET

3. above: internal iliac; below: superficial inguinal
1. Compare 1⁰/2⁰ follicle with respect to appearance and which is active?

2. Compare lymph node drainage of the gonads with that of the scrotum?

3. What is the embryologic origin of the thymus?
1. 1⁰: dense/inactive, 2⁰ clear/active

2. gonads: para-aortic nodes; scrotum: superficial inguinal nodes

3. 3rd pouch
1. Compare lymphatic drainage of stomach, duodenum, and colon?

2. Compare the site of B cell maturation with T cell maturation?

3. Which cells have MHC-I and which cells have MHC-2?
1. stomach: celiac, duodenum: SMnode, colon: IMnode

2. Bcell: Bone marrow, Tcell: Thymus

3. MHC-I all nucleated cells (not RBCs), MHC-II all APCs
1. What is the only lymphocytic member of innate immunity?

2. Describe the cytokines responsible for the formation of mature Th1 and Th2 cells?
1. NK cell

2. Th1: IL-12 Th2: IL-4
1. What are the two signals for Tc activation?

2. Describe the structure of MHC-I and MHC-II?
1. (1) IL-2 from Th and (2) MHC-I from infected cell on CD8

2. MHC-I: α/β chains, MHC-II: α/ β2-microglobin
1. What are the two signals for Th activation?

2. What type of organisms can stimulate macrophages without the Th1 intermediary? How do they do this?
1. (1) MHC-2 from APC on CD4 (2) B7 from APC on CD28 on Th

2. G- bacteria use LPS to automatically stimulate macrophages on CD14 receptors
1. Describe the cytokines emitted during a Th1/macrophage interaction?

2. What cytokines are responsible for activation of NK cells? (3)
1. Mac: IL-1 TNF-A, Lymphocyte: INF-G, IL-2

1. IL12, INFa, INFb
1. What cytokines are released by Th1 to activate CD8 cells? Which one inhibits a Th2 response*?

2. What are the two signals for B cell class switching?
1. IL2, INF-G*

2. (1) IL4 or IL5 from Th2 (2) CD40L from Th2 on CD40 on Bcell
1. What cytokines are released by Th2 to activate B cells? Which one inhibits a Th1 response*?
1. IL4, IL5, IL10*
1. What part of the Ig is responsible for isotype and for idiotype?

2. Describe isotype switching in terms of effects on mRNA?

3. What is DAF and what condition results in a deficiency of this protein?
1. Fab: idiotype, Fc: isotype

2. alternate splicing leads to isotype switching

3. Decay-accelerating factor; without it, causes complement mediated RBC hemolysis (paroxysmal nocturnal hemoglobinuria)
1. Which part of the Ig is responsible for fixing complement? Which part is responsible for binding Ag?

2. Give two examples of thymus independent antigens and the consequences of this?

3. What cell is CD16+?
1. complement: Fc; binds Ag: Fab

2. capsules and LPS are only polysaccharides and can't signal via MHC-II; they directly stimulate immune response IgM w/o memory (no IgG)

3. NK cell
1. What is the most abundant Ig isotype in the blood?

2. What cell is CD14+?

3. Deficiency of C1-esterase results in what?
1. IgG

2. Macrophage

3. hereditary angioedema
1. What is the only Ab isotype capable of crossing the placenta?

2. What cell is CD56+?

3. What is the function of the 'a' split complement proteins versus the 'b' split complement proteins?
1. IgG

2. NK cell

3. A: anaphylactic/recruitment, B: binding/opsonization
1. What Ab isotypes can be found on the surface of the B cell? (2)

2. INF-a and INF-b recruit NK cells. What ELSE do they do?

3. Diagram the complement pathways.
1. IgM, IgD

2. these also act as transcription factors for a ribonuclease that degrades viral mRNA

3. SEE SHEET