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23 Cards in this Set
- Front
- Back
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Trypanosoma and Leishmania classification
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hemoflagellates
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Trypanosoma and Leishmania my by using
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flagella
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Trypanosoma and Leishmania transmited by
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insect vextors
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Trypanosoma and Leishmania baisc morpholigic stages
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Amastigote Promastigote
Epimastigotes Trypomastigotes |
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Trypanosoma and Leishmania distinguisihg feature
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kinetoplast- single large mitochondrion assoc. with the flagellar basal body
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D KINETOPLAST
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A Kinetoplast is a disk-shaped mass of circular DNAs inside a large mitochondrion that contains many copies of the mitochondrial genome.
Kinetoplast - is also associated with the flagellar base. kDNA - can be used to speciate the organism/diagnosis |
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Amastigote Promastigote
Epimastigotes Trypomastigotes WHAT DETERMINES WHICH IS WHICH? |
POSITION OF BASAL BODY IN CELL
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Leishmaniasis ORIGIN
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VECTOR BORNE
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Leishmaniasis TRANSMISSION
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BY SANDFLIES-FEMALES. LIVE IN MOIST SOIL. MOSQUITO NETS DONT KEEP THEM OUT!
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4 types leshmania
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1 - Cutaneous Leishmaniasis -CL
L. tropica, L. t. major, L. t. minor and L. ethiopica Oriental sore, Delhi ulcer, Delhi or Baghdad boil 2 - Mucocutaneous Leishmaniasis - MCL L. braziliensis, L. mexicana and L. peruviana Espundia, sponge face 3 - Visceral Leishmaniasis - VL L. donovani, L. infantum Kala-azar, black disease, dumdum fever 4 - Post Kala-Azar Dermal Leishmaniasis -PKDL L. donovani, L. infantum |
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LEISHMANIA CYCLE
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INJECTED BY FLY INTO SKIN AND ENTERS CELL. REPRODUCES INSIDE ENDOSOME. CELL RUPTURES AND INFECTS OTHER CELLS. CORE OF PARASITIZED CELLS FORM. THEN 3 OPTIONS:
CORE REMAINS IN SKIN=CUTANEOUS FORM RELEASED INTO BLOODSTERAM=SYSTEMIC/VISCERAL FORM REMAINS TO SKIN AND METAHTESIZE TO MUCOUS=MUCOCUTANEOUS FORM |
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CUTANEOUS LEISHMENASIS SX
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DRY ULCER AT ITE OF BITE-LOOKS LIKE ROTTING APPLE
LEAVES A DEPRESSED SCAR GRANULOMA FORMS LESION IS PAINLESS AND NON HEALING |
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MUCOCUTANEOUS LEISHMENASIS SX
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Simple skin lesion
SECONDARY mucosal involvement DESTROYS MUCOUS MEMBRANES! DISTORTED NOSE, ETC... 2ND LESION CAN OCCUR LONG AFTER PRIMARY LESION |
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VISCERAL LEISHMENASIS OCCURANCE
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VERY RARE
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VISCERAL LEISHMENASIS PROGNOSIS
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FATAL IF UNTREATED
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VISCERAL LEISHMENASIS LOCATION
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AFRICA, INDIA
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VISCERAL LEISHMENASIS ORIGIN
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ZOONIS FROM ANIMAL VECTOR TO HUMANS
ALSO HUMAN TO HUMAN |
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T/F VISCERAL LEISHMENASIS PRODUCES PRIMARY LOCAL LESION
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F
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VISCERAL LEISHMENASIS LOCALIZE AND MULTIPLY IN
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PHAGOCYTIC CELLS. THEN SPREAD TO OTHER ORGANS.
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VISCERAL LEISHMENASIS SX
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ENLARGED LYMPH NODES SPLEEN AND LIVER
FATIGUE/ANEMIA INTERMITTENT FEVER HYPERPIGMENTED GRANULAMOUTS AREAS DEATH |
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POST KALO -ZAR DOERMAL LESHMENEISIS (PKDL) SX
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macular, maculo-papular or nodular rash
EX. GUY WITH BIG BUBBLE LIKE RASH ON FACE |
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LEISHMANIA DX
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DEMONSTRATION OF PARASITE IN BLOOD OR LYMPH
SPLEEN BIOPSY IS VERY DANGEROUS SCRAPING OF ULCER CULTURE |
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LEISHMANIA TX
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Amphotheracin B
AVOID ANTIMONIALS |
