#6 Vitamins Pharm 10-13-06

Front 1

over-indigestion of fat-soluble vitamines

Back 1

1) Vit. A-induced hydrocephalus
2) Vit. D-induced hypercalcemia

Front 2

special cases which need supplemental vitamins?

Back 2

1) pregnancy, lactation
2) improper absorption
3) Ab therapy
4) hemodialysis
5) HAL
6) poor diet

Front 3

water-soluble vitamins

Back 3

1) Thiamine (B1)
2) Riboflavin (B2)
3) Nicotinic acid (Niacin)
4) Pyridoxin (B6)
5) Pantothenic acid
6) Biotin
7) Folic acid
8) Cyanocobalamin (B12)
9) Ascorbic acid (Vit. C)

Front 4

fat-soluble vit.

Back 4

1) A
2) D
3) E
4) K

Front 5

thiamine (B1) is converted to active coenzyme

Back 5

thiamine pyrophosphate

Front 6

thiamine pyrophosphate is needed for?

Back 6

1) decarboxylation rxs (pyruvate)
2) pentose in hexose-monophosphate shunt

Front 7

low thiamine

Back 7

Beriberi

Front 8

Beriberi causes?

Back 8

1) muscle weakness
2) < appetite
3) peripheral edema
4) < BP
5) < temp.

Front 9

severe thiamine deficiency?

Back 9

Korsakoff's syndrome
alcoholics

Front 10

severe thiamine deficiency is asso. with?

Back 10

1) peripheral poluneuritis
2) loss of feeling in legs
3) memory impairment
4) encephalopathy

Front 11

riboflavin (B2) is converted to coenzymes

Back 11

1) falvin mononucleotide
2) flavin dinucleotide

Front 12

riboflabin is important in

Back 12

H ion transport oxidative enzyme processes

Front 13

first symptoms of riboflavin deficiency

Back 13

1) pharyngitis
2) angular stomatitis

Front 14

other s/s of riboflavin deficiency

Back 14

1) glossitis
2) denuded lips
3) dermatitis of face, trunk, extremities
4) anemia
5) peripheral neuropathy
6) cataracts

Front 15

nicotinic acid (niacin) is converted to?

Back 15

1) nicotinamide adenine dinucleotide (NAD)
2) NAD phosphate (NADP) coenzymes

Front 16

nicotinic acid is required for?

Back 16

oxidation/reduction rxn in tissue respiration

Front 17

nicotinic acid deficiency?

Back 17

Pellegra

Front 18

s/s of Pellegra?

Back 18

1) dermatitis
2) diarrhea
3) salivation
4) N/V
5) swollen tongue
6) dementia
7) motor/sensory nerve disturbance

Front 19

niacin toxicity

Back 19

1) flushing
2) pruritis
3) hepatotoxicity
4) hyperuricemia
5) peptic ulcers

Front 20

pyridoxine (B6) is converted to?

Back 20

pyridoxal phosphate by pyridoxal kinase

Front 21

pyridoxine acts as coenzymes for conversion of?

Back 21

1) tryptophan to serotonin
2) methionine to cysteine

Front 22

pyridoxine deficiency is seen frequently in?

Back 22

alcoholics

Front 23

s/s of pyridoxine deficiency

Back 23

1) dermatitis
2) CNS dysfunction
3) Sz
4) peripheral neuritis

Front 24

pantohtenic acid is converted into?

Back 24

coenzyme A

Front 25

pantothenic acid is needed for enzymatically driven

Back 25

acetylation reactions

Front 26

Biotin is coenzyme for?

Back 26

1) carboxylation rxs
2) fatty acid synthesis

Front 27

s/s of biotin deficiency

Back 27

1) glossitis
2) anorexia
3) dermatits
4) mental depression

Front 28

biotin deficiency is seen more frequently in?

Back 28

infants and pts with HAL

Front 29

folic acid act as a?

Back 29

carbon transfer agent

Front 30

active form of folic acid

Back 30

tetrahydrofolate (B12 is required)

Front 31

folic acid deficiency

Back 31

1) GI disease
2) alcoholics

Front 32

most common symp. of folic acid deficiency

Back 32

megaloblastic anemia

Front 33

cyanocobalamine (B12)is needed for?

Back 33

DNA synthesis

Front 34

first sign of B12 deficiency?

Back 34

megaloblastic anemia

Front 35

deficiency of ascorbic acid (vit. C) causes?

Back 35

scurvy
S/s = gingivitis, petechia, decreased wound healing

Front 36

fucntion of vit. A

Back 36

1) retina
2) mucosal
3) epithelial cells
4) bone development
5) reproduction
6) embryonic growth
7) stabilize membranes

Front 37

severe vit. A deficiency causes?

Back 37

night blindness

Front 38

severe s/s of hypervitaminosis (vit. A)

Back 38

1) hepatosplenomegaly with cirrhosis
2) > ICP with neuro change
3) hypercalcemia

Front 39

function of vit. D

Back 39

1) maintenance of Ca and phos
2) sterols = hormones

Front 40

vit. D deficiency in children

Back 40

rickets (bone deformity)

Front 41

vit.D deficiency in adults

Back 41

osteomalacia

Front 42

vit. D hypervitaminosis

Back 42

1) hypercalcemia
2) muscleweakness
3) fatigue
4) headache

Front 43

Vit. E

Back 43

1) in plants
2) potent antioxidants

Front 44

vit. K is needed in synthesis of

Back 44

several blood clotting factors