531 - Med Chem I - Exam Ii - Structures

Front 1

Name this structure and class

Back 1

Acetylcholine Chloride

Muscarinic and Nicotinic Agonist

Front 2

Draw Acetylcholine Chloride

Back 2

Front 3

Name this drug and class

Back 3

Carbachol Chloride

Non-selective Muscarinic/Nicotinic agonist

Front 4

Draw Carbachol Chloride

Back 4

Front 5

Name this compound and class

Back 5

Pilocarpine

Muscarinic agonist

Front 6

Draw Pilocarpine

Back 6

Front 7

Name this drug

Back 7

Acetylcholine

Front 8

Draw Acetylcholine

Back 8

Front 9

Name this drug

Back 9

Muscarine

Front 10

Draw Scopolamine

Back 10

Front 11

Name this drug

Back 11

Telenzepine

Front 12

Name this drug

Back 12

Dicyclomine

Front 13

Draw Benztropine

Back 13

Front 14

Name this drug

Back 14

Methantheline

Front 15

Draw Methantheline

Back 15

Front 16

Name this drug

Back 16

Propantheline

Front 17

Name this drug

Back 17

Succinylcholine

Front 18

Draw Succinylcholine

Back 18

Front 19

Name the two possible drugs for this structure

Back 19

Turocurarine R=H

Metocurine R=Me

Front 20

Draw the structures for Tubocurarine and Metocurine

Back 20

Front 21

Name this drug

Back 21

Decamethonium

Front 22

Draw Decamethonium

Back 22

Front 23

Draw Pancuronium

Back 23

Front 24

Name the amino acids in the active site of acetylcholinesterase.

Back 24

1. Glu 327
2. His 440
3. Ser 203
4. Trp 86
5. Phe 338

Front 25

Name this molecule.

Back 25

Tetraalkylammonium ion

Front 26

Name this molecule.

Back 26

Neostigmine.

Front 27

What does the image depict?

Back 27

An aged enzyme after exposure to a nerve agent.

Front 28

Draw isofluorophate/ DFP/Floropryl.

Back 28

Front 29

What is malathion used for?

Back 29

Insecticide.

Front 30

Name the above molecule.

Back 30

Sarin (GB); nerve agent.

Front 31

Name the above compound.

Back 31

Albuterol

Front 32

Name the above structure, and the parent compound it stems from.

Back 32

Aziridinium ion; beta-haloalkylamines

Front 33

Name the above compound.

Back 33

beta-haloalkylamine

Front 34

Name the above compound.

Back 34

Biolterol.

Front 35

Draw a structure of colterol.

Back 35

Front 36

What group of compounds is the above scaffold representative of?

Back 36

Ergot derivatives.

Front 37

Name the above compound.

Back 37

Dichlorisopreterenol

Front 38

Draw a structure of isoproterenol.

Back 38

Front 39

Name the above compound.

Back 39

Metaproterenol

Front 40

Name the above compound.

Back 40

Nadalol

Front 41

Fill in the missing enzymes/intermediates.

Back 41

1. L-Tyrosine
2. Tyrosine Hydroxylase
3. L-DOPA
4. PLP
5. Dopamine beta-hydroxylase

Front 42

Name the above compound.

Back 42

Phenoxybenzamine

Front 43

Draw a structure of Regitine.

Back 43

Front 44

Name the above compound.

Back 44

Pindolol

Front 45

Name the above compound.

Back 45

Pirbuterol

Front 46

Draw a structure of Salmeterol.

Back 46

Front 47

Draw a structure of Propanolol.

Back 47

Front 48

Name the above compound.

Back 48

Timolol

Front 49

Name the compounds that correspond to the R groups.

Back 49

1. Prazosin
2. Terazosin
3. Doxazosin

Front 50

What receptor do R1 substituents influence the activity of?

Back 50

beta; act as an agonist

Front 51

True or False: Larger derivatives at R1 favor beta 1 receptors over beta 2 receptors.

Back 51

False.

Front 52

Alpha selectivity is observed in what type of substitution at R2?

Back 52

Methyl

Front 53

If a ring with a single hydroxy at 3' is substituted, which type of receptor specificity is observed?

Back 53

alpha selectivity

Front 54

Name the above compound.

Back 54

Paroxetine/Paxil

Front 55

Name the above compound.

Back 55

Sertraline/Zoloft

Front 56

Name the above compound.

Back 56

Citalopram/Celexa

Front 57

Name the above compound.

Back 57

Alosetron

Front 58

Name the above compound when (1) R=CH3 and (2) R= H

Back 58

1) Amitryptilline
2) Nortyrptilline

Front 59

Name the above compound.

Back 59

Clozapine

Front 60

Name the class of drug the above compound belongs to.

Back 60

MAO inhibitor (deprenyl; irreversible)

Front 61

Name the above compound.

Back 61

Dimethyltryptamine

Front 62

Draw fluoxetine/Prosac

Back 62

Front 63

Draw Imipramine/Desipramine.

Back 63

Where imipramine corresponds to R=CH3 and desipramine corresponds to R=H.

Front 64

Name the above compound.

Back 64

MDMA

Front 65

Name the above compound.

Back 65

Mescaline

Front 66

Name the class of drug the above compound belongs to.

Back 66

MAO inhibitor (nialamide; irreversible)

Front 67

Where and how is the above compound produced?

Back 67

Produced by metabolism of fluoxetine by CYP2D6 once ingested.

Front 68

Name the above compound.

Back 68

Ondansetron/Zofran

Front 69

What popular drug combination is pictured?

Back 69

Phen-Fen

Front 70

Name the structures above.

Back 70

1. Tryptophan
2. 5-Hydroxyltryptophan (5-HTP)
3. Serotonin (5-HT)

Front 71

What class of drug does the above compound belong to?

Back 71

MAO Inhibitor (tranylcypromine; irreversible)