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369 Cards in this Set
- Front
- Back
spinal cord tract a/w: |
dorsal column/medial lemniscus
|
|
spinal cord tract a/w:
voluntary motor to the body |
lateral corticospinal tract
|
|
spinal cord tract a/w:
pain and temp sensation |
spinothalamic tract
|
|
spinal cord tract a/w:
voluntary motor to the head and neck |
corticobulbar tract
|
|
spinal cord tract a/w:
postural adjustments and head movement |
vestibular spinal tract
|
|
Sx's a/w tract lesion:
dorsal columns |
impaired proprioception & sensation
|
|
Sx's a/w tract lesion:
lateral corticospinal tract |
spastic paralysis
|
|
Sx's a/w tract lesion:
spinothalamic |
loss of pain & temperature sensation
|
|
Sx's a/w tract lesion:
ventral horn |
flaccid paralysis
|
|
Sx's a/w tract lesion:
ventral white commissure |
flaccid paralysis
|
|
what are the MC locations for aneurysms in the circle of willis & what is classic presentation of each
|
ACA = bitemporal hemoanopia
PCA = CN3 palsy |
|
area of brain lesion a/w:
contralateral hemiballismus |
subthalamus
|
|
area of brain lesion a/w:
eyes look toward lesion |
frontal eye field
|
|
area of brain lesion a/w:
eyes look away from lesion |
PPRF
|
|
area of brain lesion a/w:
paralysis on upward gaze |
superior caliculus
|
|
area of brain lesion a/w:
hemispatial neglect |
non dominant parietal
|
|
area of brain lesion a/w:
coma |
RAS
|
|
area of brain lesion a/w:
poor repitition |
arcuate fasciculus
|
|
area of brain lesion a/w:
poor comprehension |
wernicke's
|
|
area of brain lesion a/w:
poor vocal expression |
broca's
|
|
area of brain lesion a/w:
resting tremor |
basal ganglia
|
|
area of brain lesion a/w:
intention tremor |
cerebellar hemisphere
|
|
area of brain lesion a/w:
hyperorality, hypersexuality, disinhibited behavor |
bilateral amygdala
|
|
area of brain lesion a/w:
personality changes |
frontal lobe
|
|
area of brain lesion a/w:
dysarthria |
cerebellar vermis
|
|
area of brain lesion a/w:
agraphia and acalcula |
dominant parietal
|
|
spinal cord lesion a/w:
polio & west nile |
anterior horns
|
|
spinal cord lesion a/w:
fasciculation but also spastic paralysis |
ALS
|
|
spinal cord lesion a/w:
impaired propioception and pupils that do not react to light |
syphilis
|
|
spinal cord lesion a/w:
bilateral loss of pain and temp below the lesion, hand weakness |
syringomyelia
|
|
spinal cord lesion a/w:
bilateral loss of vib sense and spastic paralysis of legs then arms |
B12 def
|
|
spinal cord lesion a/w:
bilateral loss of pain and temp, bilateral spastic paralysis and bilateral flaccid paralysis |
ant spinal artery syndrome
|
|
nerve responsible for:
smell |
CN I (olfactory)
|
|
nerve responsible for:
sight |
CN II (optic)
|
|
nerve responsible for:
medial, superior, inferior rectus & inferior oblique muscles (EOM's of the eyes except down & outward/abduction) |
CN III (oculomotor)
NOTE: CN III palsy --> "down & out" syndrome i.e. unopposed CN IV (down) & CN VI (out/abduction) |
|
nerve responsible for:
eye lid opening |
CN III (oculomotor nerve)
|
|
nerve responsible for:
sphincter muscle of the eyes |
CN III (oculomotor)
|
|
nerve responsible for:
superior oblique (i.e. downward EOM) |
CN IV (trochlear)
|
|
nerve responsible for:
muscles of mastication |
CN V (trigeminal nerve)
|
|
nerve responsible for:
lateral rectus (i.e. outward EOM/abduction) |
CN VI (abducens)
|
|
nerve responsible for:
taste of ant 2/3 |
CN VII (facial nerve)
|
|
nerve responsible for:
balance |
CN VIII (vestibulocochlear nerve)
|
|
nerve responsible for:
monitor carotid sinus |
CN IX (glossopharyngeal nerve)
|
|
nerve responsible for:
visceral autonomics |
CN X (vagus)
|
|
nerve responsible for:
sensation of trachea, esophagus, & viscera |
CN X (vagus)
|
|
nerve responsible for:
laryngeal, pharyngeal muscles |
CN X (vagus)
|
|
nerve responsible for:
head turning |
CN XI (accessory nerve)
|
|
nerve responsible for:
tongue movement |
CN XII (hypoglossal nerve)
|
|
decussation of this spinal tract:
dorsal column |
medulla
|
|
decussation of this spinal tract:
lateral corticospinal tract |
medullary pyrimad
|
|
decussation of this spinal tract:
spinalthalamic tract |
white ventral commissure (1-3 segments up from lissauer's tract)
|
|
what cerebral artery is a/w aphasia
|
MCA
|
|
features of brown-sequard syndrome
|
ANT HORN: Ipsilateral flaccid paralysis (level of lesion)
DC/ML: Ipsilateral loss of vibration/touch (below) LCST: Ipsilateral spastic paralysis (below) STT: Contralateral loss of pain & temp (1-3 levels below) |
|
meningitis organisms <1 month
|
GBS
E coli Listeria |
|
Rx for meningitis <1 month
|
Cefotaxime* or Gentamycin
Ampicillin (Listeria coverage) *Ceftriaxone is CI'd in children due to biliary sludging |
|
meningitis organisms in 1 month to 60 years
|
S Pneumo
N Meningitis H Influenza |
|
Rx for meningitis 1 month to 60 years
|
Cefotaxime or Ceftriaxone
Vancomycin (for PCN-resist Pneumococcus) Dexamethasone (if > 6 months old) |
|
meningitis organisms >60 years
|
S Pneumo
Listeria Neisseria G- Bacilli |
|
Rx for meningitis >60 years
|
Cefotaxime or Ceftriaxone
Vancomycin (for PCN-resist Pneumococcus) Ampicillin (for Listeria coverage) Dexamethasone |
|
why is dexamethasone given with or prior to first antibiotic for meningitis
|
CHILDREN: reduces risk of neurolog sequelae (e.g. deafness), esp
HiB TB Meningitidis ADULTS: reduces morbidity & mortality in adults, esp Pneumococcal Meningitidis |
|
organism responsible for meningitis:
gram + diplococci |
pneumococcal
|
|
organism responsible for meningitis:
gram - diplococci |
neisseria
|
|
organism responsible for meningitis:
small pleomorphic gram - coccobacilli |
H influ
|
|
organism responsible for meningitis:
gram + rods and coccobacilli |
listeria
|
|
prophylaxis for those in close contact with meningitis with HiB or meningococcal
|
rifampin
ciprofloxacin |
|
when should a CT be done as a next step instead of LP in a px with meningitis
|
SIGNS OF INCR'D ICP:
focal neurologic defects pupil asymmetry papilledema seizure suspicion of mass effect SOFT TISSUE INFECTION AT SITE OF LP BLEEDING DIATHESIS CARDIOPULMONARY INSTABILITY |
|
what are the 4 MC sequelae of meningitis in children
|
hearing loss
mental retardation seizure d/o spastic paralysis |
|
a px with AIDS has meningitis, what should be performed
|
india ink (r/o Cryptococcus)
|
|
Rx for fungal meningitis
|
amphoteracin B (intrathecally)
> 6 weeks should also receive dexamethasone |
|
Rx for TB meningitis
|
Rifampin
INH pyrizinamide ethambutal |
|
what is the most effective way to prevent meningitis in a newborn
|
Ampicillin during labor to GBS+ mothers
|
|
what other drug should be given with antibiotics in a px suspected to have meningitis & why
|
DEXAMETHASONE:
prevents neurologic sequelae (e.g. deafness in children) decreases morbidity/mortality in adults |
|
MC location of berry aneurysm
|
Anterior Communicating Artery |
|
which pathogen is a/w viral meningitis to the temporal lobe
|
HSV
|
|
features of reyes syndrome
|
encephalitis
hepatitis (hypoglcemia) |
|
what infections are a/w birds
|
west nile
avian influenza ("bird flu") histoplasmosis cryptococcus psittacosis (chlamydophila psittaci) |
|
how should a person bitten by an animal suspected to have rabies be treated
|
clean wound with
povidone iodine virucidal agent administer rabies Ig and vaccine tetanus prophylaxis |
|
what is a feared complication of polio
|
respiratory muscle paralysis
|
|
how does encephalitis presentation differ from meningitis
|
MENINGITIS:
HA's nausea/vomiting neck pain fever ENCEPHALITIS: HA's nausea/vomiting neck pain fever +AMS +focal neurological deficits |
|
what does CSF pressure, WBC's, glucose, & protein show for:
normally |
PRESSURE: 50 - 180
WBCs: < 5 GLUCOSE: 40 - 70 PROTEIN: 20 - 45 |
|
what does CSF pressure, WBC's, glucose, & protein show for:
bacterial meningitis |
PRESSURE: incr'd
WBCs: incr'd (predominantly PMN's) GLUCOSE: decr'd PROTEIN: incr'd |
|
what does CSF pressure, WBC's, glucose, & protein show for:
viral meningitis |
PRESSURE: incr'd
WBCs: incr'd (predominantly lymphocytes) GLUCOSE: normal PROTEIN: normal |
|
what does CSF pressure, WBC's, glucose, & protein show for:
TB/fungal meningitis |
PRESSURE: incr'd
WBCs: incr'd (predominantly lymphocytes) GLUCOSE: decreased PROTEIN: increased |
|
term a/w reyes syndrome
|
hepatoencephalitis
|
|
Rx for tension headache
|
NSAIDS
|
|
Rx for cluster headache
|
100% O2
sumatriptan dihydroergotamine |
|
Rx for migraine
|
sumatriptan
dihydroergotamine NSAIDS antiemetics |
|
what can be used to prophylaxis for migraines
|
NSAIDS
CCB (e.g. verapamil) B-Blockers (e.g. propranolol, metoprolol) TCA's (e.g. amitriptyline, nortriptyline) Anticonvulsants (e.g. valproic acid, topiramiate, gabapentin) |
|
what is the pattern of pain in a migraine
|
unilateral, throbbing pain
|
|
what is the pattern of pain in a tension headache
|
bilateral tightness/pain
a/w neck pain |
|
px with poorly controlled diabetes and tension headaches, what should be checked before Rx
|
LABS: Cr, BUN, GFR (to check renal fxn)
Tx: NSAIDS |
|
what is the most worrisome sequela for pseudotumor cerebri
|
vision loss
|
|
what CSF pressure is indicative of pseudotumor cerebri
|
>200 in nonobese person
>250 in obese |
|
what is the first line Rx for pseudotumor cerebri
|
acetozolamide
|
|
Headache a/w:
made worse by foods containing tyramine |
migraine
|
|
Headache a/w:
obese woman with papilledema |
pseudotumor cerebri
|
|
Headache a/w:
jaw muscle pain |
temporal
|
|
Headache a/w:
periorbital pain with ptosis and miosis |
cluster
|
|
Headache a/w:
photophobia and phonophobia |
migraine
|
|
Headache a/w:
bilateral frontal and occipital pressure |
tension
|
|
Headache a/w:
lacrimation and rhinorrhea |
cluster
|
|
Headache a/w:
elevated ESR |
temporal
|
|
Headache a/w:
worst headache of my life |
subarachnoid hemorrhage
|
|
Headache a/w:
extraocular muscle palsies |
cavernous sinus thrombosis
|
|
Headache a/w:
scintillating scotomas prior to headache |
migraine with aura
|
|
Headache a/w:
before or after orgasm |
postcoital cephalgia
|
|
Headache a/w:
responsive to 100% O2 |
cluster
|
|
Headache a/w:
trauma to head, where HA begins days after, even persists for weeks and doesnt go away |
subdural
|
|
what is the next step in a person is begins to suddenly get headaches that are progressively worse
|
MRI - brain (to rule out tumor)
|
|
MCC of headache in a 40 year old women in frontal area that gets worse by bending over
|
sinus headache
|
|
preferred anti-HTN in a px with chronic HTN and recurrent migraines
|
CCB (e.g. verapamil)
B-Blockers (e.g. propranolol, metoprolol) |
|
Rx woman with facial pain whenever she is lightly touched
|
Dx: trigeminal neurolgia
Tx: carbamazepine |
|
lesion to brain a/w:
agraphia with acalculia |
dominant parietal
|
|
lesion to brain a/w:
hemispatial neglect syndrome |
non-dominant parietal
|
|
lesion to brain a/w:
personality changes |
frontal
|
|
lesion to brain a/w:
coma |
RAS
|
|
bacteria a/w with meningitis in newborn
|
GBS
E coli Listeria |
|
Rx for newborn with meningitis
|
Ampicillin
+ cefotaxime or gentamycin |
|
what should always be done before and LP
|
evaluate for increase ICP (examine fundi for papilledema)
|
|
anticoagulant of choice for:
first TIA |
aspirin
|
|
anticoagulant of choice for:
TIA or stroke due to atrial fib |
warfarin
|
|
anticoagulant of choice for:
TIA or stroke + CAD |
clopidogrel
|
|
anticoagulant of choice for:
repeated TIA or stroke while on aspirin |
Aggrenox (ASA + dipyridamole) or Clopidogrel
|
|
what are the surgical indications for carotid endarterectomy
|
symptomatic men = 50-69%
symptomatic women = 70-99% asymptomatic pts = 80-99% |
|
how can you differentiate ischemic from hemorrhagic stroke
|
CT
|
|
major signs and symptoms of TIA
|
focal neurological defect
amaurosis fugax slurred speach decreased coordination |
|
what anticoagulant is given for a px with first TIA?
Another TIA while on ASA? |
1ST TIA: Aspirin
2ND TIA: Aggrenox (ASA + dipyridamole) or Clopidogrel |
|
how long must a focal neurological defect last to qualify and a stroke
|
> 24 hours
|
|
what is the timeframe for thrombolytic therapy in cases of ischemic stroke
|
3 hours
|
|
what is the principle cause of a lacunar infarct
|
HTN
|
|
a px with DVT develops stroke, what study should be performed
|
TEE (looking for patent foreman ovale)
|
|
neurological defect a/w:
ACA |
Contralateral loss of sensory &/or motor information in the TRUNK & LOWER EXTREMITY
|
|
neurological defect a/w:
MCA |
Contralateral loss of sensory &/or motor information in the FACE & UPPER EXTREMITY & bilateral visual abnormlities
IF DOMINANT HEMISPHERE: broca's, wernicke's, condution, &/or global aphasia IF NON-DOMINANT HEMISPHERE: hemineglect |
|
neurological defect a/w:
PCA |
unilateral hemianopia with macular sparing (blindness if bilateral PCA)
|
|
neurological defect a/w:
basilar artery |
CN abnormalities
Contralateral full body weakness & decreased sensation Vertigo, loss of coordination, difficulty speaking, visual abnormalities Altered level of consciousness, coma |
|
"cortical sings" seen with strokes
|
APHASIA
(inability to produce &/or comprehend language) HEMIANOPSIA NEGLECT APRAXIA (d/o of motor planning --> loss of ability to execute or carry out learned purposeful mvmts, despite having desire & physical ability) |
|
neurological defect a/w:
pure motor hemiparesis (lacunar stroke) |
WEAKNESS: of face, arm, & leg on one side of the body
ABSENT SENSORY DEFICITS ABSENT CORTICAL SIGNS |
|
neurological defect a/w:
pure sensory stroke (lacunar stroke) |
NUMBNESS: of face, arm, & leg on one side of the body
ABSENT MOTOR DEFICITS ABSENT CORTICAL SIGNS |
|
neurological defect a/w:
ataxic hemiparesis (lacunar stroke) |
IPSILATERAL WEAKNESS: of limb |
|
neurological defect a/w: |
WEAKNESS & NUMBNESS: of face, arm, & leg on one side of the body
ABSENT CORTICAL SIGNS |
|
neurological defect a/w: |
FACIAL WEAKNESS, DYSARTHRIA, & DYSPHAGIA |
|
Dx
child presents to ER with mental status changes, hypoglycemia and lesions suggestive of chicken pox |
reyes syndorme
|
|
what type of headache causes unilateral, severe periorbital headache with tearing
|
cluster
|
|
Dx
CSF analysis shows low glucose, elevated neutrophils and gram positive diplococci |
S pneumo meningitis
|
|
what Rx are used for SAH
|
labetolol
nimodipine phenytoin anticoagulant reversal |
|
when are anticonvulsants used with cerebral hemorrhage
|
PROPHYLACTICALLY:
parenchymal hemorrhage SYMPTOMATIC/SEIZURES: subarachnoid hemorrhage |
|
what are the 3 most feared complications of parenchymal hemorrhage
|
uncal herniation
hydrocephaly SAH |
|
what is the MCC of epidural hematoma
|
rupture of middle meningeal artery tear
|
|
what is the MCC of subdural hematoma
|
rupture of bridging veins tear
|
|
if a px has a brain hematoma, should you perform an LP and why
|
No, LP is CI'd b/c incr'd risk of brain herniation
(instead, perform CT) |
|
What is the treatment for SAH
|
Stop any anticonvulsants |
|
what are the 5 main lacunar syndromes that may arise from lacunar infarct
|
pure motor hemiparesis
pure sensory stroke ataxic hemiparesis sensory motor stroke dysarthria clumsy hand syndrome |
|
ring enhancing lesion on CT with seizures could be what
|
"DR MAGIC"
D = Demylenating Ds (e.g. MS) R = Radiation Necrosis or Resolving Hematoma (i.e. contusion) M = Metastasis A = ABSCESS (most common) G = Glioblastoma Multiforme I = Infarct (subacute) or Infection (HSV, Neurocysticercosis, Toxoplasma) C = Cancer (lymphoma) |
|
what is seen in the CSF of SAH
|
increase pressure
RBC's in serial tubes xanthochromia (if couple-day-old stroke) |
|
which meds are known for causing seizures
|
LOWERS SEIZURE THRESHHOLD:
bupropion buspirone enflurane many narcotics theophylline psychostimulants MEDICATION WITHDRAWAL benzos barbs alcohol anticonvulsants OTHER CAUSES: B6 def (important in production of GABA) |
|
presentation of seizure:
simple partial |
FOCAL sensory deficits
(e.g. parasthesias, hallucinations) FOCAL motor deficits (e.g. repetitive or purposeless mvmts) NO loss of consciousness |
|
presentation of seizure:
complex partial |
hallucinations (auditory, visual, olfactory)
automatisma (repeated coordinated mvmt) deja vu IMPAIRED consciousness |
|
presentation of seizure:
generalized convulsive |
muscle contractions/jerking (e.g. tonic, clinic, tonic-clonic, myoclonic, atonic)
incontinence LOSS of consciousness WITH post-ictal confusion Todd's paralysis (possible) |
|
presentation of seizure:
absence |
IMPAIRED consciousness (brief/seconds)
possible eye-blinking normal muscle tone NO post-ictal confusion |
|
Rx to prevent myoclonic seizure
|
valproate
|
|
Rx to prevent absence seizure
|
ethosuximide, valproate
|
|
Rx to prevent partial seizure
|
phenytoin, carbamazepine, lamotrigine
|
|
Rx to prevent grand mal (tonic-clonic)
|
valproate
carbamazepine phenytoin lamotrigine topiramate |
|
seizure med a/w:
gingival hyperplasia |
phenytoin
|
|
seizure med a/w:
DOC for absence |
ethosuximide
|
|
seizure med a/w:
second choice for absence |
valproate
|
|
seizure med a/w:
DOC for trigeminal neuralgia |
carbamazepine
|
|
what is the MCC of drug-induced SJS
|
lamotrigine
|
|
what is the initial concern for seizures mgmt
|
ABC's
|
|
MCC of seizure:
children aged 2- 10 y/o? young adults aged 18 - 35 y/o? |
CHILDREN 2 - 10 Y/O:
febrile ADULTS 18 - 35 Y/O: trauma |
|
what is the BP goal and Rx for:
ischemic stroke |
<220/120
labetolol nicardipine |
|
what is the BP goal and Rx for:
intracerebral hemorrhage |
SBP <140-160
labetolol nitroprusside |
|
what is the BP goal and Rx for:
SAH |
SBP <150
labetolol nimodipine (prevents vasospasm) |
|
what is the Rx of choice for mania with psychosis
|
atypical antipsychotics
(also haloperidol) |
|
parkinson Rx:
used in early disease and has neuroprotective effects |
selegiline (MAO-B inhibitor)
|
|
parkinson Rx:
rescue therapy for sudden akinetic episode |
apomorphine
|
|
parkinson Rx:
potentiates levodopa |
COMT Inhibitors:
entacapone/talcapone |
|
parkinson Rx:
tremors |
Anticholinergics:
trihexyphenidyl/benztropine |
|
parkinson Rx:
increases dopamine release |
amantadine
|
|
Rx MC'ly used in parkinsons
|
levodopa/carbidopa
|
|
brain lesion seen in px with parkinsons
|
depigmentation of substantia nigra
|
|
what will an electromyogram reveal in ALS
|
widespread muscular denervation
motor block |
|
Rx for ALS
|
riluzole
|
|
life expectancy for ALS
|
3-5 years from time of diagnosis
|
|
major symptoms of huntingtons
|
choreiform mvmts
cognitive decline (dementia) |
|
what drugs are used to Rx huntingtons
|
Dopamine antagonists
(e.g. haloperidol & risperidone) tetrabenazine |
|
what is the major SE of atypical antipsychotis
|
weight gain
DM/DKA |
|
what are the signs and symptoms of TCA overdose
|
anticholinergic SE
cardiotoxicity neurotoxicity |
|
how are TCA toxicity managed
|
Na+ bicarb (for QRS > 100 msec's)
benzos (for seizures) Monitor > 6 hrs (for cardiotoxicity) |
|
what are the unique features of picks disease
|
aka frontotemporal dementia
dementia behavioral & personality changes progressive aphasia frontal temporal atrophy on CT/MRI |
|
what are the unique features of lewy body dementia
|
dementia
parkinsons features (e.g. bradykinesia, parkinsonian gait, cogwheel rigidity) visual hallucinations repeated falls/syncope |
|
66 yo woman with forgetfulness and decreased bilateral parietal lobe activity on PET scan
|
alzheimers (cortical atrophy)
|
|
Rx for alzheimers
|
CHOLINESTERASE INHIBITORS:
donepezil rivastigmine galantamine NMDA RECEPTOR BLOCKER: memantidine |
|
how can you differentiate vascular dementia from alzheimers
|
MRI:
Vascular --> multiple infarcts Alzheimer's --> cortical atrophy |
|
what 2 symptoms should make you think of MS
|
Unilateral optic neuritis with central vision loss
internuclear ophthalmoplegia (damage to MLF) |
|
signs/sx's of unilateral optic neuritis
|
pain worsened with eye mvmt
central vision loss afferent pupillary defect (i.e. marcus gunn pupil) MRI: affected nerve diffusely enhances |
|
signs/sx's of internuclear ophthalmoplegia
|
ipsilateral loss of adduction on lateral gaze |
|
what is the most sensitive test for MS |
MRI of Brain |
|
what Rx's decreases the frequency of MS relapses
|
IFN-B
Glatiramer Acetate |
|
what is Rx for acute MS relapse
|
corticosteroids, methotrexate
|
|
what neuronal tract in the first compressed in syringmyelia
|
1ST AFFECTED: crossing fibers of spinal thalamic tract
(loss of pain & temp a few segments below the level of the lesion/syrinx) 2ND AFFECTED: anterior horn cells (flaccid paralysis & muscle atrophy of the hands & arms) |
|
what is the pattern of pain in a migraine
|
unilateral, throbbing pain
|
|
what is the pattern of pain in a tension headache
|
bilateral pain a/w tightness in neck/shoulders
|
|
Rx for lithium-induced nephrogenic DI
|
hydrochlorothiazide
amiloride (closes Na+ channels in collecting tubules) |
|
classic presentation of Guillain-Barre Syndrome
|
ascending paralysis presenting after a recent infection (e.g. viral illness, diarrhea, etc)
|
|
how can guillain barre be Dx'd
|
CSF will show albuminocytologic dissociation
(elevated protein and normal WBC) electromyography reveals slowing of nerve conduction velocity (i.e. demyelination) |
|
how do you Tx ileus in px with guillain barre
|
erythromycin
neostigmine |
|
what causes fasciculations and fibrillations at rest on EMG
|
LMN lesion
|
|
what causes a silent EMG at rest and a decrease in the amplitude of muscle contraction on stimulation
|
intrinsic muscle disease (e.g. myositis, muscle inflammation, MD)
|
|
lung cancer may be a/w what d/o, causing muscle weakness
|
lambert eaton
|
|
what test is Dx of MG
|
tensilon test (edrophonium)
|
|
what is the Rx for benign essential tremor
|
B-blockers
benzos primidone thalamotomy/deep brain stimulation (for refactory cases) For refractory cases: thalamotomy, deep brain stimulation |
|
Dx
woman presents with ptosis and diplopia that worsens through out the day |
Myasthenia Gravis
(AB's to ACh receptors at post-synaptic NMJ) |
|
Rx for guillain barre
|
supportive care
plasmaphoresis and IVIG (steroids NOT beneficial) |
|
how is Bell's palsy differentiated from a motor cortex stroke
|
BELL'S PALSY:
unilateral UPPER & LOWER facial paralysis MOTOR CORTEX STROKE: unilateral LOWER facial paralysis |
|
classic presentation of GBS
|
SYMMETRIC MUSCLE WEAKNESS
initially "stocking-glove" distribution ascending paralysis respiratory paralysis facial muscle/oropharyngeal weakness AUTONOMIC DYSFUNCTION ABSENT/DEPRESSED DTR'S = HALLMARK OF GBS |
|
what are some features of acute dystonia
|
acute onset
sustained contractions of the limbs/neck |
|
what are some features of tardive dyskinesia
|
delayed onset
repetitive mouth/facial movements |
|
what is the MC adult brain tumors
|
"MGM Studios"
Metastasis (#1) Glioblastoma Meningimoma Schwannoma |
|
what is the MC pediatric brain tumors
|
astrocytoma (#1)
medulloblastoma ependymoma |
|
what is the next step once a brain tumor has been identified on CT or MRI
|
full body CT scan to look for mets
(head, neck, chest, abdomen, & pelvis) bone scan (to look for mets) |
|
what are some characteristics of neurofibromatosis I
|
neurofibromas
café-au-lait spots lisch nodules freckling of axilla and inguinal area |
|
what are the sleep patterns of depressed patients
|
decr'd slow wave (N3)
incr'd REM decr'd REM latency |
|
what are the sleep patterns in elderly
|
decr'd slow wave (N3)
decr'd REM incr'd REM latency frequent night-time awakenings |
|
what is the difference between nightmare and night terror
|
NIGHTMARE
during REM if pt appears awake, they actually ARE awake NIGHT TERROR during non-REM if pt appears awake, they actually are NOT awake |
|
what is pickwickian syndrome
|
aka OBESITY HYPOVENTILATION SYNDROME (OHS)
obesity hypersomnolence dyspnea hypoxemia (cyanosis, polycythemia, plethora) pulmonary HTN --> R-side HF --> peripheral edema |
|
Rx for narcolepsy
|
modafinil (Provigil)
|
|
Rx for cataplexy
|
venlafaxine
fluoxetine atomoxetine |
|
insomnia Rx a/w:
vivid dreams |
melatonin
|
|
insomnia Rx a/w:
studies show no benefits |
valerian
|
|
insomnia Rx a/w:
poor sleep quality and anticholinergic SE |
antihistamines
|
|
insomnia Rx a/w:
priapism |
trazodone
|
|
insomnia Rx a/w:
arrhythmias and anticholinergic SE |
TCA
|
|
insomnia Rx a/w:
works on benzo receptor and causes rebound insomnia |
zolpidem/zaleplon
|
|
insomnia Rx a/w:
may be used long term |
eszopiclone
|
|
insomnia Rx a/w:
works on melatonin receptors (t/f non-addictive) but must be avoided in hepatic insufficiency |
ramelteon
|
|
Rx for RLS
|
Da Agonists:
pramipexole ropinirole levodopa/carbidopa |
|
what are the stages of sleep & assoc'd wave forms
|
"BATS Drink Blood"
AWAKE/EYES OPEN: beta-waves AWAKE/DRIFTING OFF TO SLEEP: alpha-waves STAGE N1: theta-waves STAGE N2: sleep spindles & k-complexes STAGE N3: delta-waves REM: beta-waves |
|
benzos have which effect on sleep stages
|
incr's N2
decr's N3 & REM |
|
MC sources of metastatic brain tumors
|
"Lots of Bad Stuff Kill Glia"
Lungs Breast Skin (melanoma) Kidney GI Tract |
|
what two meds can be used as prophylaxis against meningococcal meningitis
|
ciprofloxacin
rifampin |
|
what two meds can be used to treat chronic HTN and prevent recurrent migraines
|
CCB
B-blockers |
|
what are Rx's for MG & how do they work
|
Rx's: edrophonium, neostigmine, & pyridostigmine
MOA: anticholinergics: AChE-Inhib's --> incr'd ACh |
|
cause of syncope:
while shaving |
carotid sinus hypersensitivity
|
|
cause of syncope:
while singing |
vasovagal syncope
|
|
cause of syncope:
positive tilt test |
orthostatic hypotension
|
|
cause of syncope:
prolonged loss of consciousness |
cerebrovascular etiology
|
|
cause of syncope:
preceded by palpitations |
cardiogenic
|
|
cause of syncope:
type 1 diabetes interrupted while eating |
hypoglycemia
|
|
what is the MCC of syncope
|
vasovagal syncope
|
|
what should you first think of in a px who presents to ER with loss of consciousness
|
Thiamine (prior to glucose)
Glucose (presumed hypoglycemia) Naloxone (presumed opiod overdose) |
|
in an intact brainstem, ice water should cause eyes to
|
move to same side
|
|
what are the elbows doing in decorticate posturing
|
flexing
|
|
what should be done before giving px glucose who loss consciousness
|
thiamine
|
|
what measurements make for a positive tilt-test
|
Incr'd HR > 20 bpm (while standing)
decr'd SBP > 20 points (while standing) decr'd DBP > 10 points (while standing) |
|
Why is thiamine given in a glucose infusion to alcoholics with hypoglycemia
|
Glucose without thiamine can exacerbate damage to mammillary bodies & worsen Wernicke's Encephalopathy
|
|
what is a commonly used antidepressant that can cause seizures
|
bupropion
|
|
where is brocas area located & what artery supplies that area
|
frontal lobe
left MCA |
|
what is amblyopia
|
decreased vision due to disruption in normal development (e.g. cataracts, strabismus) prior to age 10
|
|
possible presentations of amblyopia & what is tx
|
PRESENTATIONS:
esotropia (inward deviation) exotropia (outward deviation) diplopia refractive error not correctable with lenses TREATMENT: vision training (patch the good eye) levodopa-carbidopa |
|
what eye d/o is an example of "afferent defect";
what is pathology & signs/sx's |
MARCUS GUNN PUPIL
PATHOLOGY: optic nerve damage prior to pretectal nucleus IPSILATERAL EYE: direct pupillary light reflex absent (i.e. afferent) consensual pupillary light reflex present CONTRALATERAL EYE: direct pupillary light reflex present consensual pupillary light reflex absent (i.e. afferent from contralateral eye) |
|
what eye d/o an example of "efferent defect";
what is pathology & signs/sx's |
OCULOMOTOR NERVE (CN III) DEFECT
PATHOLOGY: damage to the CN III or one of its branches IPSILATERAL EYE: direct & consensual pupillary light reflex absent (i.e. efferent) CONTRALATERAL EYE: direct & consensual pupillary light reflex present (i.e. no effect on contralateral efferents) |
|
MCC of blindness > 55 yo
|
macular degeneration
|
|
MCC of blindness <55 yo
|
DM
|
|
MCC of blindness in blacks of any age
|
glaucoma
|
|
eye discharge & other features:
bacterial conjunctivitis |
DISCHARGE:
purulent, copious d/c 24 hours a day OTHER FEATURES: GC, Chlamydia, Trachomatis S. Aureus, S. Pneumo |
|
eye discharge & other features:
viral (adenovirus) conjunctivitis |
watery d/c
DISCHARGE: watery eyelid may be sealed in AM OTHER FEATURES: fever, URI, lymphadenopathy, pharyngitis highly contagious (aka "pink eye") |
|
eye discharge & other features:
allergic conjunctivitis |
DISCHARGE:
bilateral, watery d/c eyelids may be sealed AM OTHER FEATURES: pruritus other allergy sx's |
|
Cause of red eye a/w:
collagen vascular defect |
uveitis
scleritis |
|
Cause of red eye a/w:
potential serious complication of corneal ulceration |
herpes simplex keratitis
|
|
Cause of red eye a/w:
colored halos |
acute angle closure galucoma
|
|
Cause of red eye a/w:
itching eyes |
allergic conjuctivitis
|
|
Cause of red eye a/w:
preauricular lymph node enlargement |
viral conjuctivitis
|
|
Cause of red eye a/w:
dry eyes |
keratoconjunctivitis sicca
(feature of sjogren's syndrome) |
|
Cause of red eye a/w:
shallow anterior chambers |
acute angle closure glaucoma
|
|
MCC of conjuctivitis in first 24 hours of life
|
chemical irritation 2nd/2 antibiotic eye drops
(given to newborn for potentially undx'd GC/chlamydia in mother) |
|
classic features of orbital cellulitis
|
infection involving the eye
proptosis (bulging) ophthalmoplegia (weakness/paralysis of 1+ EOM's) decr'd/double vision pain with mvmt (orbital is more severe than periorbital cellulitis) |
|
classic feature of periorbital cellulitis
|
infection of skin surrounding the eye
normal vision (periorbital is less severe than orbital cellulitis) |
|
what is the Rx for orbital cellulitis
|
vancomycin
cefotaxime |
|
what is chalazion
|
CHRONIC inflammation of INTERNAL MEIBOMIAN sebaceous glands --> EYELID swelling
|
|
what is the Rx for chalazion
|
usually self-limiting
refractory cases: surgery intralesional steroid injection |
|
what is hordeolum
|
aka "stye"
ACUTE infection of EXTERNAL SEBACEOUS glands (Zeiss or Mol) --> tender, swollen LID MARGIN |
|
what is the Rx for hordeolum
|
hot compression
unresolved after 48 hrs: I&D +/- antibiotic ointment |
|
what is anterior blepharitis
|
infection of EYELIDS & LASHES 2nd/2 seborrhea -->
red swollen LID MARGINS and dandruff on LASHES |
|
what is the Rx for anterior blepharitis
|
wash lid margins daily with shampoo |
|
what is the next step in newborn with chemical burn to the eye
|
copious saline irrigation
|
|
what diseases are associated with uveitis
|
SERONEG SPONDYLOARTHROPATHIES (HLA-B27):
psoriatic arthritis ankylosing spondylitis IBD reactive arthritis JUVENILE IDEOPATHIC ARTHRITIS BEHCET'S DISEASE SARCOIDOSIS KAWASAKI'S DISEASE |
|
what is the relationship b/w strabismus & amblyopia
|
strabismus is MCC of amblyopia
|
|
what is the relationship b/w amblyopia & strabismus
|
strabismus is MCC of amblyopia
|
|
what would be the visual field defect of a lesion of the optic tract
|
homonomous hemianopsia
|
|
what are the sx's of Horner's Syndrome;
what is the classic etiology |
HORNER'S TRIAD:
ptosis miosis anhydrosis ETIOLOGY: lesion of SS trunk tumor in apex of lung (i.e. Pancoast Tumor) |
|
Dx
px that has periods of mood disturbances while psychotic as well as periods of psychosis with normal affect |
schizoaffective disorder
|
|
what are the major features of acute angle closure galucoma
|
severe eye pain
red/inflamed eye dilated pupil hard orbit |
|
what are the major features of open angle glaucoma
|
cupping of optic disk (cup:disc ratio >50%)
|
|
Dx & Tx:
woman w/new onset rapid vision loss & pain w/mvmt |
Dx: optic neuritis of MS (i.e. acute MS flare)
Tx: IV steroids (e.g. methylprednisolone) |
|
what disorders are a/w cherry red spot of the macula
|
retinal artery occlusion
neimann pick's tay sach's |
|
what is the tx for macular degeneration
|
Vit C, E, & B-carotene
copper & zinc intravitreal ranibizumab laser photocoagulation |
|
what is the tx for retinal detachment
|
laser photocoagulation
cryotherapy |
|
what is the pattern of vision loss in glaucoma
|
peripheral to central
|
|
what is the pattern of vision loss in macular degeneration
|
central to peripheral
|
|
what is the differential diagnosis for dislocation of the lens of the eye
|
Marfan's syndrome (dislocates upward)
Homocystinuria (dislocates downward) Alport's |
|
what is the Rx for closed-angle glaucoma
|
ACETAZOLAMIDE: incr's aqueous humor removal --> decr's interocular pressure
PILOCARPINE (cholinergic agonist): given after pressure is lowered (by acetazolamide) decr's obstruction --> incr's aqueous humor removal --> decr's interocular pressure SURGICAL: peripheral laser irodotomy |
|
what is the Rx for open-angle glaucoma
|
DECREASE AQUEOUS HUMOR PRODUCTION:
B-blockers (e.g. timolol) a-adrenergic agonists (e.g. apraclonidine) INCREASE AQUEOUS HUMOR REMOVAL: PG anologs (e.g. latanoprost) a-adrenergic agonists (e.g. apraclonidine) cholinergic agonsits (e.g. pilocarpine) carbonic anhydrase inhibitors (e.g acetazolamide) IV mannitol for refractory cases SURGICAL: peripheral laser irodotomy |
|
classic presentation of pt with cataracts
|
DECR'D VISION:
painless, progressive, & usually bilateral near-sightedness (early manifestation) difficulty reading fine print difficulty night driving/reading road signs possible disabling "glare" (oncoming headlights/bright sunlight) |
|
eye abnormalities in pt with Vit A deficiency
|
night blindness
xerophthalmia (i.e. dry eyes) bitot spots |
|
what are bitot spots
|
areas of abnormal squamous cell proliferation & keratinization of the conjunctiva due to Vit A def.
|
|
what is central serous chorioretinopathy
|
temporary buildup of fluid under a portion of the macula
results in a "patch" of vision loss (due to retinal detachment) |
|
what is the classic pt with chorioretinopathy
|
20-50 y/o male
highly stressed Type A personality |
|
what is the typical complaint of a patient with retinal detachment
|
sudden onset of painless flashing lights
large number of floaters "shade comes down" over vision of one eye |
|
Dx
young child with loss of red light reflex |
retinoblastoma
(PE finding = leukocoria) |
|
first line therapy for depression
|
SSRI
|
|
what is seen in otoscopy of bullous myringitis
|
large reddish vesicles on the TM
|
|
what is bullous myringitis & with what is it often assoc'd
|
bullous/vesicular inflammation of TM
a/w acute otitis media |
|
what organism is a/w bullous myringitis
|
Mycoplasma pneumoniae
|
|
what is the Rx for bullous myringitis
|
macrolides
|
|
what is the underlying cause of benign paroxysmal positional vertigo
|
dislodged otolith in the semicircular canal
|
|
presentation of acute labyrinthitis
|
nausea/vomiting
vertigo nystagmus HEARING LOSS |
|
what is a cholesteatoma
|
overgrowth of desquamated keratin debris within middle ear space
may eventually erode the ossicular chain & external auditory canal --> conductive hearing loss a/w chronic middle ear infection |
|
features of cholesteatoma
|
grayish white "pearly" lesion behind TM
conductive hearing loss vertigo |
|
what is ramsay hunt syndrome
|
aka herpes zoster oticus
shingles of the ear, geniculate ganglion, & CN VIII |
|
what is the Rx for ramsay hunt syndrome
|
narcotic analgesic (pain relief)
oral steroid (decrease inflammation) antiviral therapy |
|
what symptoms are seen in menieres disease
|
TRIAD: vertigo, decr'd hearing, & tinnitus
PLUS: nausea, vomiting, & ear "fullness" |
|
presentation of vestibular neuritis
|
nausea/vomiting
vertigo nystagmus PRESERVED AUDITORY FUNCTION |
|
when do the guidelines say "observation" is appropriate in a child with acute otitis media
|
GENERAL CRITERIA:
illness is mild appropriate f/u is avail antibiotics can be started promply if sx's worsen 6 MONTHS - 2 YEARS unilateral without otorrhea general criteria are met > 2 YEARS unilateral or bilateral without otorrhea general guidelines are met ANTIBOITICS SHOULD BE STARTED: if improvement is not noted in 48-72 hours |
|
what is the MCC of conductive hearing loss in adults
|
otosclerosis
(abnormal growth of ossicles of the middle ear) |
|
what is the MCC of sensorineural hearing loss in adults
|
presbycusis
(age-related high f hearing loss) |
|
what are the important characteristics seen on otoscopic exam of a pt with otitis media
|
Bulging TM with decr'd mobility
(most sensitive dx'c finding) |
|
How can the Weber test help distinguish conductive hearing loss form sensorineural hearing loss
|
CONDUCTIVE:
sound lateralizes to AFFECTED/ABNORMAL side SENSORINEURAL: sound lateralizes to UNAFFECTED/NORMAL side Mnemonic: CANS (Conductive --> Abnormal; Sensorineural --> Normal) |
|
compare distinguishing features of the following:
Labyrinthitis Vestibular Neuritis Meniere's Disease |
LABYRINTHITIS:
n/v/vertigo nystagmus AND decr'd hearing VESTIBULAR NEURITIS: n/v/vertigo nystagmus WITHOUT decr'd hearing MENIERE'S: n/v/vertigo decr'd hearing WITHOUT nystagmus + tinnitus + ear "fullness" |
|
sx of macular degeneration
|
loss of central vision
|
|
types of macular degeneration
|
exudative: less common, more severe --> sudden visual loss from leakage of fluid into retina --> abnormal bv formation non-exudative: atrophy anda degeneration of central retina, drusen forms under the pigment
|
|
clinical findings of glaucoma
|
increaed iop damage ot optic nerveirreversible vision loss loss of ganglion cells --> atrophy of optic disk cup gets bigger
|
|
2 types of glaucoma
|
open angle: painless, silent dz course, impaired outflow of aqueous humorclosed angle: occlusion of a narrow angle, very painful with eye dilation. eye is red and painful, n/v/ha **pupil becomes non-reactive**
|
|
clinical findings of subconjunctival hemorrhage
|
red blotchy portions of the eye non an emergency, looks worse than it is
|
|
tx of subconjunctival hemorrhage
|
resolves in a few weeks on its own, but cold compresses can help
|
|
clinical findings of blepharitisetiology
|
inflamed eyelid, usually from staph infx eyelid is red, swollen and crustedforeign body sensation
|
|
tx of blepharitis
|
lid scrubs and compress, topical abx if severe
|
|
clinical findings of episcleritis
|
inflamed bv lining sclera irritation, dull ache, watery d/c sclera are blotchy
|
|
tx of episcleritis
|
self limitednsaids can be used for symptom relief
|
|
clinical findings of scleritis
|
significant eye pain ocular redness visual impairment pain on palpation of eyeball
|
|
tx of scleritis
|
topical or systemic steroids
|
|
clinical findings of superficial keratitis
|
inflammation of corneal epithelium --> impaired vision and eye pain slit lamp eval: under cobalt blue + fluorescein dye, shows micro-erosions of corneal epithelium
|
|
clinical findings of anterior uveitis
|
red around the cornea blurred visionpainphotophobiaconstricted pupil
|
|
clinical findings of herpes simplex keratitis
|
dentrite seen on cornea (with fluoroscein staining) blindness if not treated ocular irritation and photophobia
|
|
which eye conditions are associated with systemic dz
|
anterior uveitisepiscleritis scleritis
|
|
which hsv is related to hsv keratitis
|
hsv 1
|
|
sx of hyperacute bacterial conjunctivitis
|
rapid onset of copious, purulent exudate --> blindness very quickly
|
|
what organism is related to hyperacute bacterial conjunctivitis
|
n. gonorrhea
|
|
tx of hyperacute bacterial conjunctivitis
|
im ceftriaxone
|
|
who to suspect of having hyperacute bacterial conjunctivitis
|
sexually active young adult with rapid onset of copious purulent exudate
|
|
what is the #1 cause of blindness worlwide
|
trachoma
|
|
clinical features of trachoma
|
chronic conjunctival scarring
|
|
2 types of conjunctivitis caused by chlamydia
|
trachoma inclusion conjunctivitis
|
|
clinical findings of inclusion conjunctivitis
|
there is no scarring or blindness risk follicles are seen on inner margin of eye
|
|
tx of chlamydial conjunctivitis
|
oral tetracycline, doxy, or erythromycin tx partners too!
|
|
#1 cause of white reflex in children
|
congenital cataracts
|
|
sx of retinal detachment
|
floatersflashes of light grey elevated retinaperipheral loss of vision (as opposed to macular degeneration or optic neuritis)
|
|
sx of choroidal rupture
|
central scotoma retinal edema macular detachment subretinal hemorrhage
|
|
etiology of choroidal rupture
|
usually from blunt ocular trauma
|
|
sx of proliferative diabetic retinopathy
|
decreased visual acuityneovascularization
|
|
clinical findings of cmv retinitis
|
yellow-white patches of retinal opacifications, and retinal hemorrhage pts usually asx
|
|
tx of cmv retinitis
|
ganciclovir or foscarnet
|
|
vision defect in hypperosmolar hyperglycemic diabetic coma pathophysiology
|
blurry vision from hyperosmolarity
|
|
dacrocystitis
|
infection of lacrimal sac from obx at nasolacrimal duct --> pain, swelling, tenderness, rednessexpression of mucous or pus
|
|
sx in optic neuritis
|
central scotoma afferent pupillary defect changes in color perception decreased visual acuity
|
|
clinical findings of htn retinopathy
|
av nickeingcopper/silver wiringexudateshemorrhage no sx of visual impairment
|
|
pathophys of htn retinomapthy
|
focal spasm of arterioles, progressive sclerosis and narrowing
|
|
types of dm retinopathy
|
1. microaneurysms, hemorrhage, exudates, retinal edema --> vision changes2. pre-proliferative changes (cotton wool spots) 3. Prolferative (newly formed bv)
|
|
how can complications of dm retinopathy be prevented |
with laser photocoag
|