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369 Cards in this Set

  • Front
  • Back

spinal cord tract a/w:
touch, vib, pressure sensation

dorsal column/medial lemniscus
spinal cord tract a/w:
voluntary motor to the body
lateral corticospinal tract
spinal cord tract a/w:
pain and temp sensation
spinothalamic tract
spinal cord tract a/w:
voluntary motor to the head and neck
corticobulbar tract
spinal cord tract a/w:
postural adjustments and head movement
vestibular spinal tract
Sx's a/w tract lesion:
dorsal columns
impaired proprioception & sensation
Sx's a/w tract lesion:
lateral corticospinal tract
spastic paralysis
Sx's a/w tract lesion:
spinothalamic
loss of pain & temperature sensation
Sx's a/w tract lesion:
ventral horn
flaccid paralysis
Sx's a/w tract lesion:
ventral white commissure
flaccid paralysis
what are the MC locations for aneurysms in the circle of willis & what is classic presentation of each
ACA = bitemporal hemoanopia

PCA = CN3 palsy
area of brain lesion a/w:
contralateral hemiballismus
subthalamus
area of brain lesion a/w:
eyes look toward lesion
frontal eye field
area of brain lesion a/w:
eyes look away from lesion
PPRF
area of brain lesion a/w:
paralysis on upward gaze
superior caliculus
area of brain lesion a/w:
hemispatial neglect
non dominant parietal
area of brain lesion a/w:
coma
RAS
area of brain lesion a/w:
poor repitition
arcuate fasciculus
area of brain lesion a/w:
poor comprehension
wernicke's
area of brain lesion a/w:
poor vocal expression
broca's
area of brain lesion a/w:
resting tremor
basal ganglia
area of brain lesion a/w:
intention tremor
cerebellar hemisphere
area of brain lesion a/w:
hyperorality, hypersexuality, disinhibited behavor
bilateral amygdala
area of brain lesion a/w:
personality changes
frontal lobe
area of brain lesion a/w:
dysarthria
cerebellar vermis
area of brain lesion a/w:
agraphia and acalcula
dominant parietal
spinal cord lesion a/w:
polio & west nile
anterior horns
spinal cord lesion a/w:
fasciculation but also spastic paralysis
ALS
spinal cord lesion a/w:
impaired propioception and pupils that do not react to light
syphilis
spinal cord lesion a/w:
bilateral loss of pain and temp below the lesion, hand weakness
syringomyelia
spinal cord lesion a/w:
bilateral loss of vib sense and spastic paralysis of legs then arms
B12 def
spinal cord lesion a/w:
bilateral loss of pain and temp, bilateral spastic paralysis and bilateral flaccid paralysis
ant spinal artery syndrome
nerve responsible for:
smell
CN I (olfactory)
nerve responsible for:
sight
CN II (optic)
nerve responsible for:
medial, superior, inferior rectus & inferior oblique muscles (EOM's of the eyes except down & outward/abduction)
CN III (oculomotor)

NOTE: CN III palsy --> "down & out" syndrome
i.e. unopposed CN IV (down) & CN VI (out/abduction)
nerve responsible for:
eye lid opening
CN III (oculomotor nerve)
nerve responsible for:
sphincter muscle of the eyes
CN III (oculomotor)
nerve responsible for:
superior oblique (i.e. downward EOM)
CN IV (trochlear)
nerve responsible for:
muscles of mastication
CN V (trigeminal nerve)
nerve responsible for:
lateral rectus (i.e. outward EOM/abduction)
CN VI (abducens)
nerve responsible for:
taste of ant 2/3
CN VII (facial nerve)
nerve responsible for:
balance
CN VIII (vestibulocochlear nerve)
nerve responsible for:
monitor carotid sinus
CN IX (glossopharyngeal nerve)
nerve responsible for:
visceral autonomics
CN X (vagus)
nerve responsible for:
sensation of trachea, esophagus, & viscera
CN X (vagus)
nerve responsible for:
laryngeal, pharyngeal muscles
CN X (vagus)
nerve responsible for:
head turning
CN XI (accessory nerve)
nerve responsible for:
tongue movement
CN XII (hypoglossal nerve)
decussation of this spinal tract:
dorsal column
medulla
decussation of this spinal tract:
lateral corticospinal tract
medullary pyrimad
decussation of this spinal tract:
spinalthalamic tract
white ventral commissure (1-3 segments up from lissauer's tract)
what cerebral artery is a/w aphasia
MCA
features of brown-sequard syndrome
ANT HORN: Ipsilateral flaccid paralysis (level of lesion)
DC/ML: Ipsilateral loss of vibration/touch (below)
LCST: Ipsilateral spastic paralysis (below)
STT: Contralateral loss of pain & temp (1-3 levels below)
meningitis organisms <1 month
GBS
E coli
Listeria
Rx for meningitis <1 month
Cefotaxime* or Gentamycin

Ampicillin (Listeria coverage)


*Ceftriaxone is CI'd in children due to biliary sludging
meningitis organisms in 1 month to 60 years
S Pneumo

N Meningitis

H Influenza
Rx for meningitis 1 month to 60 years
Cefotaxime or Ceftriaxone

Vancomycin (for PCN-resist Pneumococcus)

Dexamethasone (if > 6 months old)
meningitis organisms >60 years
S Pneumo

Listeria

Neisseria

G- Bacilli
Rx for meningitis >60 years
Cefotaxime or Ceftriaxone

Vancomycin (for PCN-resist Pneumococcus)

Ampicillin (for Listeria coverage)

Dexamethasone
why is dexamethasone given with or prior to first antibiotic for meningitis
CHILDREN: reduces risk of neurolog sequelae (e.g. deafness), esp
HiB
TB Meningitidis

ADULTS: reduces morbidity & mortality in adults, esp
Pneumococcal Meningitidis
organism responsible for meningitis:
gram + diplococci
pneumococcal
organism responsible for meningitis:
gram - diplococci
neisseria
organism responsible for meningitis:
small pleomorphic gram - coccobacilli
H influ
organism responsible for meningitis:
gram + rods and coccobacilli
listeria
prophylaxis for those in close contact with meningitis with HiB or meningococcal
rifampin

ciprofloxacin
when should a CT be done as a next step instead of LP in a px with meningitis
SIGNS OF INCR'D ICP:
focal neurologic defects
pupil asymmetry
papilledema
seizure
suspicion of mass effect

SOFT TISSUE INFECTION AT SITE OF LP

BLEEDING DIATHESIS

CARDIOPULMONARY INSTABILITY
what are the 4 MC sequelae of meningitis in children
hearing loss

mental retardation

seizure d/o

spastic paralysis
a px with AIDS has meningitis, what should be performed
india ink (r/o Cryptococcus)
Rx for fungal meningitis
amphoteracin B (intrathecally)

> 6 weeks should also receive dexamethasone
Rx for TB meningitis
Rifampin

INH

pyrizinamide

ethambutal
what is the most effective way to prevent meningitis in a newborn
Ampicillin during labor to GBS+ mothers
what other drug should be given with antibiotics in a px suspected to have meningitis & why
DEXAMETHASONE:
prevents neurologic sequelae (e.g. deafness in children)
decreases morbidity/mortality in adults
MC location of berry aneurysm

Anterior Communicating Artery

which pathogen is a/w viral meningitis to the temporal lobe
HSV
features of reyes syndrome
encephalitis

hepatitis (hypoglcemia)
what infections are a/w birds
west nile
avian influenza ("bird flu")
histoplasmosis
cryptococcus
psittacosis (chlamydophila psittaci)
how should a person bitten by an animal suspected to have rabies be treated
clean wound with
povidone iodine
virucidal agent

administer rabies Ig and vaccine

tetanus prophylaxis
what is a feared complication of polio
respiratory muscle paralysis
how does encephalitis presentation differ from meningitis
MENINGITIS:
HA's
nausea/vomiting
neck pain
fever

ENCEPHALITIS:
HA's
nausea/vomiting
neck pain
fever
+AMS
+focal neurological deficits
what does CSF pressure, WBC's, glucose, & protein show for:
normally
PRESSURE: 50 - 180

WBCs: < 5

GLUCOSE: 40 - 70

PROTEIN: 20 - 45
what does CSF pressure, WBC's, glucose, & protein show for:
bacterial meningitis
PRESSURE: incr'd

WBCs: incr'd (predominantly PMN's)

GLUCOSE: decr'd

PROTEIN: incr'd
what does CSF pressure, WBC's, glucose, & protein show for:
viral meningitis
PRESSURE: incr'd

WBCs: incr'd (predominantly lymphocytes)

GLUCOSE: normal

PROTEIN: normal
what does CSF pressure, WBC's, glucose, & protein show for:
TB/fungal meningitis
PRESSURE: incr'd

WBCs: incr'd (predominantly lymphocytes)

GLUCOSE: decreased

PROTEIN: increased
term a/w reyes syndrome
hepatoencephalitis
Rx for tension headache
NSAIDS
Rx for cluster headache
100% O2

sumatriptan

dihydroergotamine
Rx for migraine
sumatriptan

dihydroergotamine

NSAIDS

antiemetics
what can be used to prophylaxis for migraines
NSAIDS

CCB (e.g. verapamil)

B-Blockers (e.g. propranolol, metoprolol)

TCA's (e.g. amitriptyline, nortriptyline)

Anticonvulsants
(e.g. valproic acid, topiramiate, gabapentin)
what is the pattern of pain in a migraine
unilateral, throbbing pain
what is the pattern of pain in a tension headache
bilateral tightness/pain

a/w neck pain
px with poorly controlled diabetes and tension headaches, what should be checked before Rx
LABS: Cr, BUN, GFR (to check renal fxn)

Tx: NSAIDS
what is the most worrisome sequela for pseudotumor cerebri
vision loss
what CSF pressure is indicative of pseudotumor cerebri
>200 in nonobese person

>250 in obese
what is the first line Rx for pseudotumor cerebri
acetozolamide
Headache a/w:
made worse by foods containing tyramine
migraine
Headache a/w:
obese woman with papilledema
pseudotumor cerebri
Headache a/w:
jaw muscle pain
temporal
Headache a/w:
periorbital pain with ptosis and miosis
cluster
Headache a/w:
photophobia and phonophobia
migraine
Headache a/w:
bilateral frontal and occipital pressure
tension
Headache a/w:
lacrimation and rhinorrhea
cluster
Headache a/w:
elevated ESR
temporal
Headache a/w:
worst headache of my life
subarachnoid hemorrhage
Headache a/w:
extraocular muscle palsies
cavernous sinus thrombosis
Headache a/w:
scintillating scotomas prior to headache
migraine with aura
Headache a/w:
before or after orgasm
postcoital cephalgia
Headache a/w:
responsive to 100% O2
cluster
Headache a/w:
trauma to head, where HA begins days after, even persists for weeks and doesnt go away
subdural
what is the next step in a person is begins to suddenly get headaches that are progressively worse
MRI - brain (to rule out tumor)
MCC of headache in a 40 year old women in frontal area that gets worse by bending over
sinus headache
preferred anti-HTN in a px with chronic HTN and recurrent migraines
CCB (e.g. verapamil)

B-Blockers (e.g. propranolol, metoprolol)
Rx woman with facial pain whenever she is lightly touched
Dx: trigeminal neurolgia

Tx: carbamazepine
lesion to brain a/w:
agraphia with acalculia
dominant parietal
lesion to brain a/w:
hemispatial neglect syndrome
non-dominant parietal
lesion to brain a/w:
personality changes
frontal
lesion to brain a/w:
coma
RAS
bacteria a/w with meningitis in newborn
GBS
E coli
Listeria
Rx for newborn with meningitis
Ampicillin

+

cefotaxime or gentamycin
what should always be done before and LP
evaluate for increase ICP (examine fundi for papilledema)
anticoagulant of choice for:
first TIA
aspirin
anticoagulant of choice for:
TIA or stroke due to atrial fib
warfarin
anticoagulant of choice for:
TIA or stroke + CAD
clopidogrel
anticoagulant of choice for:
repeated TIA or stroke while on aspirin
Aggrenox (ASA + dipyridamole) or Clopidogrel
what are the surgical indications for carotid endarterectomy
symptomatic men = 50-69%

symptomatic women = 70-99%

asymptomatic pts = 80-99%
how can you differentiate ischemic from hemorrhagic stroke
CT
major signs and symptoms of TIA
focal neurological defect

amaurosis fugax

slurred speach

decreased coordination
what anticoagulant is given for a px with first TIA?
Another TIA while on ASA?
1ST TIA: Aspirin

2ND TIA: Aggrenox (ASA + dipyridamole) or Clopidogrel
how long must a focal neurological defect last to qualify and a stroke
> 24 hours
what is the timeframe for thrombolytic therapy in cases of ischemic stroke
3 hours
what is the principle cause of a lacunar infarct
HTN
a px with DVT develops stroke, what study should be performed
TEE (looking for patent foreman ovale)
neurological defect a/w:
ACA
Contralateral loss of sensory &/or motor information in the TRUNK & LOWER EXTREMITY
neurological defect a/w:
MCA
Contralateral loss of sensory &/or motor information in the FACE & UPPER EXTREMITY & bilateral visual abnormlities

IF DOMINANT HEMISPHERE:
broca's, wernicke's, condution, &/or global aphasia

IF NON-DOMINANT HEMISPHERE:
hemineglect
neurological defect a/w:
PCA
unilateral hemianopia with macular sparing (blindness if bilateral PCA)
neurological defect a/w:
basilar artery
CN abnormalities

Contralateral full body weakness & decreased sensation

Vertigo, loss of coordination, difficulty speaking, visual abnormalities

Altered level of consciousness, coma
"cortical sings" seen with strokes
APHASIA
(inability to produce &/or comprehend language)

HEMIANOPSIA

NEGLECT

APRAXIA
(d/o of motor planning --> loss of ability to execute or carry out learned purposeful mvmts, despite having desire & physical ability)
neurological defect a/w:
pure motor hemiparesis (lacunar stroke)
WEAKNESS: of face, arm, & leg on one side of the body

ABSENT SENSORY DEFICITS

ABSENT CORTICAL SIGNS
neurological defect a/w:
pure sensory stroke (lacunar stroke)
NUMBNESS: of face, arm, & leg on one side of the body

ABSENT MOTOR DEFICITS

ABSENT CORTICAL SIGNS
neurological defect a/w:
ataxic hemiparesis (lacunar stroke)

IPSILATERAL WEAKNESS: of limb

IPSILATERAL ATAXIA: of limb that is out-of-proportion to the motor defect (possible gait deviation toward the affected side

ABSENT SENSORY DEFICITS

ABSENT CORTICAL SIGNS

neurological defect a/w:
sensorimotor stroke (lacunar stroke)

WEAKNESS & NUMBNESS: of face, arm, & leg on one side of the body

ABSENT CORTICAL SIGNS

neurological defect a/w:
dysarthria-clumsy hand syndrome

FACIAL WEAKNESS, DYSARTHRIA, & DYSPHAGIA

WEAKNESS & CLUMSINESS: of 1 hand

ABSENT SENSORY DEFICITS

ABSENT CORTICAL SIGNS

Dx
child presents to ER with mental status changes, hypoglycemia and lesions suggestive of chicken pox
reyes syndorme
what type of headache causes unilateral, severe periorbital headache with tearing
cluster
Dx
CSF analysis shows low glucose, elevated neutrophils and gram positive diplococci
S pneumo meningitis
what Rx are used for SAH
labetolol

nimodipine

phenytoin

anticoagulant reversal
when are anticonvulsants used with cerebral hemorrhage
PROPHYLACTICALLY:
parenchymal hemorrhage

SYMPTOMATIC/SEIZURES:
subarachnoid hemorrhage
what are the 3 most feared complications of parenchymal hemorrhage
uncal herniation

hydrocephaly

SAH
what is the MCC of epidural hematoma
rupture of middle meningeal artery tear
what is the MCC of subdural hematoma
rupture of bridging veins tear
if a px has a brain hematoma, should you perform an LP and why
No, LP is CI'd b/c incr'd risk of brain herniation
(instead, perform CT)
What is the treatment for SAH

Stop any anticonvulsants

Keep BP < 150 (labetalol; avoid nitroprusside/NTG)

Nimodipine (prevent arterial spasm)

Optimize brain environment (prevent hypoxia, fever)

Normalize blood (glucose, pH, & osmolarity)

Address cause of hemorrhage

what are the 5 main lacunar syndromes that may arise from lacunar infarct
pure motor hemiparesis

pure sensory stroke

ataxic hemiparesis

sensory motor stroke

dysarthria clumsy hand syndrome
ring enhancing lesion on CT with seizures could be what
"DR MAGIC"

D = Demylenating Ds (e.g. MS)
R = Radiation Necrosis or Resolving Hematoma (i.e. contusion)
M = Metastasis
A = ABSCESS (most common)
G = Glioblastoma Multiforme
I = Infarct (subacute) or Infection (HSV, Neurocysticercosis, Toxoplasma)
C = Cancer (lymphoma)
what is seen in the CSF of SAH
increase pressure

RBC's in serial tubes

xanthochromia (if couple-day-old stroke)
which meds are known for causing seizures
LOWERS SEIZURE THRESHHOLD:
bupropion
buspirone
enflurane
many narcotics
theophylline
psychostimulants

MEDICATION WITHDRAWAL
benzos
barbs
alcohol
anticonvulsants

OTHER CAUSES:
B6 def (important in production of GABA)
presentation of seizure:
simple partial
FOCAL sensory deficits
(e.g. parasthesias, hallucinations)

FOCAL motor deficits
(e.g. repetitive or purposeless mvmts)

NO loss of consciousness
presentation of seizure:
complex partial
hallucinations (auditory, visual, olfactory)

automatisma (repeated coordinated mvmt)

deja vu

IMPAIRED consciousness
presentation of seizure:
generalized convulsive
muscle contractions/jerking (e.g. tonic, clinic, tonic-clonic, myoclonic, atonic)

incontinence

LOSS of consciousness WITH post-ictal confusion

Todd's paralysis (possible)
presentation of seizure:
absence
IMPAIRED consciousness (brief/seconds)

possible eye-blinking

normal muscle tone

NO post-ictal confusion
Rx to prevent myoclonic seizure
valproate
Rx to prevent absence seizure
ethosuximide, valproate
Rx to prevent partial seizure
phenytoin, carbamazepine, lamotrigine
Rx to prevent grand mal (tonic-clonic)
valproate
carbamazepine
phenytoin
lamotrigine
topiramate
seizure med a/w:
gingival hyperplasia
phenytoin
seizure med a/w:
DOC for absence
ethosuximide
seizure med a/w:
second choice for absence
valproate
seizure med a/w:
DOC for trigeminal neuralgia
carbamazepine
what is the MCC of drug-induced SJS
lamotrigine
what is the initial concern for seizures mgmt
ABC's
MCC of seizure:
children aged 2- 10 y/o?
young adults aged 18 - 35 y/o?
CHILDREN 2 - 10 Y/O:
febrile

ADULTS 18 - 35 Y/O:
trauma
what is the BP goal and Rx for:
ischemic stroke
<220/120

labetolol
nicardipine
what is the BP goal and Rx for:
intracerebral hemorrhage
SBP <140-160

labetolol
nitroprusside
what is the BP goal and Rx for:
SAH
SBP <150

labetolol
nimodipine (prevents vasospasm)
what is the Rx of choice for mania with psychosis
atypical antipsychotics

(also haloperidol)
parkinson Rx:
used in early disease and has neuroprotective effects
selegiline (MAO-B inhibitor)
parkinson Rx:
rescue therapy for sudden akinetic episode
apomorphine
parkinson Rx:
potentiates levodopa
COMT Inhibitors:

entacapone/talcapone
parkinson Rx:
tremors
Anticholinergics:

trihexyphenidyl/benztropine
parkinson Rx:
increases dopamine release
amantadine
Rx MC'ly used in parkinsons
levodopa/carbidopa
brain lesion seen in px with parkinsons
depigmentation of substantia nigra
what will an electromyogram reveal in ALS
widespread muscular denervation

motor block
Rx for ALS
riluzole
life expectancy for ALS
3-5 years from time of diagnosis
major symptoms of huntingtons
choreiform mvmts

cognitive decline (dementia)
what drugs are used to Rx huntingtons
Dopamine antagonists
(e.g. haloperidol & risperidone)

tetrabenazine
what is the major SE of atypical antipsychotis
weight gain

DM/DKA
what are the signs and symptoms of TCA overdose
anticholinergic SE

cardiotoxicity

neurotoxicity
how are TCA toxicity managed
Na+ bicarb (for QRS > 100 msec's)

benzos (for seizures)

Monitor > 6 hrs (for cardiotoxicity)
what are the unique features of picks disease
aka frontotemporal dementia

dementia

behavioral & personality changes

progressive aphasia

frontal temporal atrophy on CT/MRI
what are the unique features of lewy body dementia
dementia

parkinsons features (e.g. bradykinesia, parkinsonian gait, cogwheel rigidity)

visual hallucinations

repeated falls/syncope
66 yo woman with forgetfulness and decreased bilateral parietal lobe activity on PET scan
alzheimers (cortical atrophy)
Rx for alzheimers
CHOLINESTERASE INHIBITORS:
donepezil
rivastigmine
galantamine

NMDA RECEPTOR BLOCKER:
memantidine
how can you differentiate vascular dementia from alzheimers
MRI:
Vascular --> multiple infarcts
Alzheimer's --> cortical atrophy
what 2 symptoms should make you think of MS
Unilateral optic neuritis with central vision loss

internuclear ophthalmoplegia (damage to MLF)
signs/sx's of unilateral optic neuritis
pain worsened with eye mvmt

central vision loss

afferent pupillary defect (i.e. marcus gunn pupil)

MRI: affected nerve diffusely enhances
signs/sx's of internuclear ophthalmoplegia

ipsilateral loss of adduction on lateral gaze

contralateral eye nystagmus on lateral gaze

normal b/l convergence

what is the most sensitive test for MS

MRI of Brain
(asymmetric white matter lesions of diff't ages)

MRI of Orbits
(diffuse nerve enhancement of edema & demyelination)

what Rx's decreases the frequency of MS relapses
IFN-B

Glatiramer Acetate
what is Rx for acute MS relapse
corticosteroids, methotrexate
what neuronal tract in the first compressed in syringmyelia
1ST AFFECTED: crossing fibers of spinal thalamic tract
(loss of pain & temp a few segments below the level of the lesion/syrinx)

2ND AFFECTED: anterior horn cells
(flaccid paralysis & muscle atrophy of the hands & arms)
what is the pattern of pain in a migraine
unilateral, throbbing pain
what is the pattern of pain in a tension headache
bilateral pain a/w tightness in neck/shoulders
Rx for lithium-induced nephrogenic DI
hydrochlorothiazide

amiloride (closes Na+ channels in collecting tubules)
classic presentation of Guillain-Barre Syndrome
ascending paralysis presenting after a recent infection (e.g. viral illness, diarrhea, etc)
how can guillain barre be Dx'd
CSF will show albuminocytologic dissociation
(elevated protein and normal WBC)

electromyography reveals slowing of nerve conduction velocity (i.e. demyelination)
how do you Tx ileus in px with guillain barre
erythromycin

neostigmine
what causes fasciculations and fibrillations at rest on EMG
LMN lesion
what causes a silent EMG at rest and a decrease in the amplitude of muscle contraction on stimulation
intrinsic muscle disease (e.g. myositis, muscle inflammation, MD)
lung cancer may be a/w what d/o, causing muscle weakness
lambert eaton
what test is Dx of MG
tensilon test (edrophonium)
what is the Rx for benign essential tremor
B-blockers

benzos

primidone

thalamotomy/deep brain stimulation
(for refactory cases)

For refractory cases: thalamotomy, deep brain stimulation
Dx
woman presents with ptosis and diplopia that worsens through out the day
Myasthenia Gravis
(AB's to ACh receptors at post-synaptic NMJ)
Rx for guillain barre
supportive care

plasmaphoresis and IVIG

(steroids NOT beneficial)
how is Bell's palsy differentiated from a motor cortex stroke
BELL'S PALSY:
unilateral UPPER & LOWER facial paralysis

MOTOR CORTEX STROKE:
unilateral LOWER facial paralysis
classic presentation of GBS
SYMMETRIC MUSCLE WEAKNESS
initially "stocking-glove" distribution
ascending paralysis
respiratory paralysis
facial muscle/oropharyngeal weakness

AUTONOMIC DYSFUNCTION

ABSENT/DEPRESSED DTR'S = HALLMARK OF GBS
what are some features of acute dystonia
acute onset

sustained contractions of the limbs/neck
what are some features of tardive dyskinesia
delayed onset

repetitive mouth/facial movements
what is the MC adult brain tumors
"MGM Studios"

Metastasis (#1)
Glioblastoma
Meningimoma
Schwannoma
what is the MC pediatric brain tumors
astrocytoma (#1)
medulloblastoma
ependymoma
what is the next step once a brain tumor has been identified on CT or MRI
full body CT scan to look for mets
(head, neck, chest, abdomen, & pelvis)

bone scan (to look for mets)
what are some characteristics of neurofibromatosis I
neurofibromas
café-au-lait spots
lisch nodules
freckling of axilla and inguinal area
what are the sleep patterns of depressed patients
decr'd slow wave (N3)

incr'd REM

decr'd REM latency
what are the sleep patterns in elderly
decr'd slow wave (N3)

decr'd REM

incr'd REM latency

frequent night-time awakenings
what is the difference between nightmare and night terror
NIGHTMARE
during REM
if pt appears awake, they actually ARE awake

NIGHT TERROR
during non-REM
if pt appears awake, they actually are NOT awake
what is pickwickian syndrome
aka OBESITY HYPOVENTILATION SYNDROME (OHS)
obesity
hypersomnolence
dyspnea
hypoxemia (cyanosis, polycythemia, plethora)
pulmonary HTN --> R-side HF --> peripheral edema
Rx for narcolepsy
modafinil (Provigil)
Rx for cataplexy
venlafaxine

fluoxetine

atomoxetine
insomnia Rx a/w:
vivid dreams
melatonin
insomnia Rx a/w:
studies show no benefits
valerian
insomnia Rx a/w:
poor sleep quality and anticholinergic SE
antihistamines
insomnia Rx a/w:
priapism
trazodone
insomnia Rx a/w:
arrhythmias and anticholinergic SE
TCA
insomnia Rx a/w:
works on benzo receptor and causes rebound insomnia
zolpidem/zaleplon
insomnia Rx a/w:
may be used long term
eszopiclone
insomnia Rx a/w:
works on melatonin receptors (t/f non-addictive) but must be avoided in hepatic insufficiency
ramelteon
Rx for RLS
Da Agonists:

pramipexole
ropinirole
levodopa/carbidopa
what are the stages of sleep & assoc'd wave forms
"BATS Drink Blood"

AWAKE/EYES OPEN: beta-waves
AWAKE/DRIFTING OFF TO SLEEP: alpha-waves
STAGE N1: theta-waves
STAGE N2: sleep spindles & k-complexes
STAGE N3: delta-waves
REM: beta-waves
benzos have which effect on sleep stages
incr's N2

decr's N3 & REM
MC sources of metastatic brain tumors
"Lots of Bad Stuff Kill Glia"

Lungs
Breast
Skin (melanoma)
Kidney
GI Tract
what two meds can be used as prophylaxis against meningococcal meningitis
ciprofloxacin

rifampin
what two meds can be used to treat chronic HTN and prevent recurrent migraines
CCB

B-blockers
what are Rx's for MG & how do they work
Rx's: edrophonium, neostigmine, & pyridostigmine

MOA: anticholinergics: AChE-Inhib's --> incr'd ACh
cause of syncope:
while shaving
carotid sinus hypersensitivity
cause of syncope:
while singing
vasovagal syncope
cause of syncope:
positive tilt test
orthostatic hypotension
cause of syncope:
prolonged loss of consciousness
cerebrovascular etiology
cause of syncope:
preceded by palpitations
cardiogenic
cause of syncope:
type 1 diabetes interrupted while eating
hypoglycemia
what is the MCC of syncope
vasovagal syncope
what should you first think of in a px who presents to ER with loss of consciousness
Thiamine (prior to glucose)
Glucose (presumed hypoglycemia)

Naloxone (presumed opiod overdose)
in an intact brainstem, ice water should cause eyes to
move to same side
what are the elbows doing in decorticate posturing
flexing
what should be done before giving px glucose who loss consciousness
thiamine
what measurements make for a positive tilt-test
Incr'd HR > 20 bpm (while standing)

decr'd SBP > 20 points (while standing)

decr'd DBP > 10 points (while standing)
Why is thiamine given in a glucose infusion to alcoholics with hypoglycemia
Glucose without thiamine can exacerbate damage to mammillary bodies & worsen Wernicke's Encephalopathy
what is a commonly used antidepressant that can cause seizures
bupropion
where is brocas area located & what artery supplies that area
frontal lobe

left MCA
what is amblyopia
decreased vision due to disruption in normal development (e.g. cataracts, strabismus) prior to age 10
possible presentations of amblyopia & what is tx
PRESENTATIONS:
esotropia (inward deviation)
exotropia (outward deviation)
diplopia
refractive error not correctable with lenses

TREATMENT:
vision training (patch the good eye)
levodopa-carbidopa
what eye d/o is an example of "afferent defect";
what is pathology & signs/sx's
MARCUS GUNN PUPIL

PATHOLOGY:
optic nerve damage prior to pretectal nucleus

IPSILATERAL EYE:
direct pupillary light reflex absent (i.e. afferent)
consensual pupillary light reflex present
CONTRALATERAL EYE:
direct pupillary light reflex present
consensual pupillary light reflex absent
(i.e. afferent from contralateral eye)
what eye d/o an example of "efferent defect";
what is pathology & signs/sx's
OCULOMOTOR NERVE (CN III) DEFECT

PATHOLOGY:
damage to the CN III or one of its branches

IPSILATERAL EYE:
direct & consensual pupillary light reflex absent
(i.e. efferent)
CONTRALATERAL EYE:
direct & consensual pupillary light reflex present
(i.e. no effect on contralateral efferents)
MCC of blindness > 55 yo
macular degeneration
MCC of blindness <55 yo
DM
MCC of blindness in blacks of any age
glaucoma
eye discharge & other features:
bacterial conjunctivitis
DISCHARGE:
purulent, copious d/c
24 hours a day

OTHER FEATURES:
GC, Chlamydia, Trachomatis
S. Aureus, S. Pneumo
eye discharge & other features:
viral (adenovirus) conjunctivitis
watery d/c

DISCHARGE:
watery
eyelid may be sealed in AM

OTHER FEATURES:
fever, URI, lymphadenopathy, pharyngitis
highly contagious (aka "pink eye")
eye discharge & other features:
allergic conjunctivitis
DISCHARGE:
bilateral, watery d/c
eyelids may be sealed AM

OTHER FEATURES:
pruritus
other allergy sx's
Cause of red eye a/w:
collagen vascular defect
uveitis

scleritis
Cause of red eye a/w:
potential serious complication of corneal ulceration
herpes simplex keratitis
Cause of red eye a/w:
colored halos
acute angle closure galucoma
Cause of red eye a/w:
itching eyes
allergic conjuctivitis
Cause of red eye a/w:
preauricular lymph node enlargement
viral conjuctivitis
Cause of red eye a/w:
dry eyes
keratoconjunctivitis sicca
(feature of sjogren's syndrome)
Cause of red eye a/w:
shallow anterior chambers
acute angle closure glaucoma
MCC of conjuctivitis in first 24 hours of life
chemical irritation 2nd/2 antibiotic eye drops
(given to newborn for potentially undx'd GC/chlamydia in mother)
classic features of orbital cellulitis
infection involving the eye
proptosis (bulging)
ophthalmoplegia (weakness/paralysis of 1+ EOM's)
decr'd/double vision
pain with mvmt

(orbital is more severe than periorbital cellulitis)
classic feature of periorbital cellulitis
infection of skin surrounding the eye

normal vision

(periorbital is less severe than orbital cellulitis)
what is the Rx for orbital cellulitis
vancomycin

cefotaxime
what is chalazion
CHRONIC inflammation of INTERNAL MEIBOMIAN sebaceous glands --> EYELID swelling
what is the Rx for chalazion
usually self-limiting

refractory cases:
surgery
intralesional steroid injection
what is hordeolum
aka "stye"

ACUTE infection of EXTERNAL SEBACEOUS glands (Zeiss or Mol) --> tender, swollen LID MARGIN
what is the Rx for hordeolum
hot compression

unresolved after 48 hrs:
I&D
+/- antibiotic ointment
what is anterior blepharitis
infection of EYELIDS & LASHES 2nd/2 seborrhea -->
red swollen LID MARGINS and dandruff on LASHES
what is the Rx for anterior blepharitis

wash lid margins daily with shampoo

remove scales with cotton ball

antibiotic ointment

what is the next step in newborn with chemical burn to the eye
copious saline irrigation
what diseases are associated with uveitis
SERONEG SPONDYLOARTHROPATHIES (HLA-B27):
psoriatic arthritis
ankylosing spondylitis
IBD
reactive arthritis

JUVENILE IDEOPATHIC ARTHRITIS

BEHCET'S DISEASE

SARCOIDOSIS

KAWASAKI'S DISEASE
what is the relationship b/w strabismus & amblyopia
strabismus is MCC of amblyopia
what is the relationship b/w amblyopia & strabismus
strabismus is MCC of amblyopia
what would be the visual field defect of a lesion of the optic tract
homonomous hemianopsia
what are the sx's of Horner's Syndrome;
what is the classic etiology
HORNER'S TRIAD:
ptosis
miosis
anhydrosis

ETIOLOGY:
lesion of SS trunk
tumor in apex of lung (i.e. Pancoast Tumor)
Dx
px that has periods of mood disturbances while psychotic as well as periods of psychosis with normal affect
schizoaffective disorder
what are the major features of acute angle closure galucoma
severe eye pain
red/inflamed eye
dilated pupil
hard orbit
what are the major features of open angle glaucoma
cupping of optic disk (cup:disc ratio >50%)
Dx & Tx:
woman w/new onset rapid vision loss & pain w/mvmt
Dx: optic neuritis of MS (i.e. acute MS flare)

Tx: IV steroids (e.g. methylprednisolone)
what disorders are a/w cherry red spot of the macula
retinal artery occlusion

neimann pick's

tay sach's
what is the tx for macular degeneration
Vit C, E, & B-carotene
copper & zinc

intravitreal ranibizumab

laser photocoagulation
what is the tx for retinal detachment
laser photocoagulation

cryotherapy
what is the pattern of vision loss in glaucoma
peripheral to central
what is the pattern of vision loss in macular degeneration
central to peripheral
what is the differential diagnosis for dislocation of the lens of the eye
Marfan's syndrome (dislocates upward)

Homocystinuria (dislocates downward)

Alport's
what is the Rx for closed-angle glaucoma
ACETAZOLAMIDE: incr's aqueous humor removal --> decr's interocular pressure

PILOCARPINE (cholinergic agonist):
given after pressure is lowered (by acetazolamide)
decr's obstruction --> incr's aqueous humor removal --> decr's interocular pressure

SURGICAL:
peripheral laser irodotomy
what is the Rx for open-angle glaucoma
DECREASE AQUEOUS HUMOR PRODUCTION:
B-blockers (e.g. timolol)
a-adrenergic agonists (e.g. apraclonidine)

INCREASE AQUEOUS HUMOR REMOVAL:
PG anologs (e.g. latanoprost)
a-adrenergic agonists (e.g. apraclonidine)
cholinergic agonsits (e.g. pilocarpine)
carbonic anhydrase inhibitors (e.g acetazolamide)
IV mannitol for refractory cases

SURGICAL:
peripheral laser irodotomy
classic presentation of pt with cataracts
DECR'D VISION:
painless, progressive, & usually bilateral
near-sightedness (early manifestation)
difficulty reading fine print
difficulty night driving/reading road signs
possible disabling "glare" (oncoming headlights/bright sunlight)
eye abnormalities in pt with Vit A deficiency
night blindness

xerophthalmia (i.e. dry eyes)

bitot spots
what are bitot spots
areas of abnormal squamous cell proliferation & keratinization of the conjunctiva due to Vit A def.
what is central serous chorioretinopathy
temporary buildup of fluid under a portion of the macula

results in a "patch" of vision loss (due to retinal detachment)
what is the classic pt with chorioretinopathy
20-50 y/o male

highly stressed

Type A personality
what is the typical complaint of a patient with retinal detachment
sudden onset of painless flashing lights

large number of floaters

"shade comes down" over vision of one eye
Dx
young child with loss of red light reflex
retinoblastoma
(PE finding = leukocoria)
first line therapy for depression
SSRI
what is seen in otoscopy of bullous myringitis
large reddish vesicles on the TM
what is bullous myringitis & with what is it often assoc'd
bullous/vesicular inflammation of TM

a/w acute otitis media
what organism is a/w bullous myringitis
Mycoplasma pneumoniae
what is the Rx for bullous myringitis
macrolides
what is the underlying cause of benign paroxysmal positional vertigo
dislodged otolith in the semicircular canal
presentation of acute labyrinthitis
nausea/vomiting
vertigo
nystagmus
HEARING LOSS
what is a cholesteatoma
overgrowth of desquamated keratin debris within middle ear space

may eventually erode the ossicular chain & external auditory canal --> conductive hearing loss

a/w chronic middle ear infection
features of cholesteatoma
grayish white "pearly" lesion behind TM

conductive hearing loss

vertigo
what is ramsay hunt syndrome
aka herpes zoster oticus

shingles of the ear, geniculate ganglion, & CN VIII
what is the Rx for ramsay hunt syndrome
narcotic analgesic (pain relief)

oral steroid (decrease inflammation)

antiviral therapy
what symptoms are seen in menieres disease
TRIAD: vertigo, decr'd hearing, & tinnitus

PLUS: nausea, vomiting, & ear "fullness"
presentation of vestibular neuritis
nausea/vomiting
vertigo
nystagmus
PRESERVED AUDITORY FUNCTION
when do the guidelines say "observation" is appropriate in a child with acute otitis media
GENERAL CRITERIA:
illness is mild
appropriate f/u is avail
antibiotics can be started promply if sx's worsen

6 MONTHS - 2 YEARS
unilateral
without otorrhea
general criteria are met

> 2 YEARS
unilateral or bilateral
without otorrhea
general guidelines are met

ANTIBOITICS SHOULD BE STARTED: if improvement is not noted in 48-72 hours
what is the MCC of conductive hearing loss in adults
otosclerosis
(abnormal growth of ossicles of the middle ear)
what is the MCC of sensorineural hearing loss in adults
presbycusis
(age-related high f hearing loss)
what are the important characteristics seen on otoscopic exam of a pt with otitis media
Bulging TM with decr'd mobility
(most sensitive dx'c finding)
How can the Weber test help distinguish conductive hearing loss form sensorineural hearing loss
CONDUCTIVE:
sound lateralizes to AFFECTED/ABNORMAL side

SENSORINEURAL:
sound lateralizes to UNAFFECTED/NORMAL side

Mnemonic: CANS
(Conductive --> Abnormal; Sensorineural --> Normal)
compare distinguishing features of the following:
Labyrinthitis
Vestibular Neuritis
Meniere's Disease
LABYRINTHITIS:
n/v/vertigo
nystagmus AND decr'd hearing

VESTIBULAR NEURITIS:
n/v/vertigo
nystagmus WITHOUT decr'd hearing

MENIERE'S:
n/v/vertigo
decr'd hearing WITHOUT nystagmus
+ tinnitus
+ ear "fullness"
sx of macular degeneration
loss of central vision
types of macular degeneration
exudative: less common, more severe --> sudden visual loss from leakage of fluid into retina --> abnormal bv formation non-exudative: atrophy anda degeneration of central retina, drusen forms under the pigment
clinical findings of glaucoma
increaed iop damage ot optic nerveirreversible vision loss loss of ganglion cells --> atrophy of optic disk cup gets bigger
2 types of glaucoma
open angle: painless, silent dz course, impaired outflow of aqueous humorclosed angle: occlusion of a narrow angle, very painful with eye dilation. eye is red and painful, n/v/ha **pupil becomes non-reactive**
clinical findings of subconjunctival hemorrhage
red blotchy portions of the eye non an emergency, looks worse than it is
tx of subconjunctival hemorrhage
resolves in a few weeks on its own, but cold compresses can help
clinical findings of blepharitisetiology
inflamed eyelid, usually from staph infx eyelid is red, swollen and crustedforeign body sensation
tx of blepharitis
lid scrubs and compress, topical abx if severe
clinical findings of episcleritis
inflamed bv lining sclera irritation, dull ache, watery d/c sclera are blotchy
tx of episcleritis
self limitednsaids can be used for symptom relief
clinical findings of scleritis
significant eye pain ocular redness visual impairment pain on palpation of eyeball
tx of scleritis
topical or systemic steroids
clinical findings of superficial keratitis
inflammation of corneal epithelium --> impaired vision and eye pain slit lamp eval: under cobalt blue + fluorescein dye, shows micro-erosions of corneal epithelium
clinical findings of anterior uveitis
red around the cornea blurred visionpainphotophobiaconstricted pupil
clinical findings of herpes simplex keratitis
dentrite seen on cornea (with fluoroscein staining) blindness if not treated ocular irritation and photophobia
which eye conditions are associated with systemic dz
anterior uveitisepiscleritis scleritis
which hsv is related to hsv keratitis
hsv 1
sx of hyperacute bacterial conjunctivitis
rapid onset of copious, purulent exudate --> blindness very quickly
what organism is related to hyperacute bacterial conjunctivitis
n. gonorrhea
tx of hyperacute bacterial conjunctivitis
im ceftriaxone
who to suspect of having hyperacute bacterial conjunctivitis
sexually active young adult with rapid onset of copious purulent exudate
what is the #1 cause of blindness worlwide
trachoma
clinical features of trachoma
chronic conjunctival scarring
2 types of conjunctivitis caused by chlamydia
trachoma inclusion conjunctivitis
clinical findings of inclusion conjunctivitis
there is no scarring or blindness risk follicles are seen on inner margin of eye
tx of chlamydial conjunctivitis
oral tetracycline, doxy, or erythromycin tx partners too!
#1 cause of white reflex in children
congenital cataracts
sx of retinal detachment
floatersflashes of light grey elevated retinaperipheral loss of vision (as opposed to macular degeneration or optic neuritis)
sx of choroidal rupture
central scotoma retinal edema macular detachment subretinal hemorrhage
etiology of choroidal rupture
usually from blunt ocular trauma
sx of proliferative diabetic retinopathy
decreased visual acuityneovascularization
clinical findings of cmv retinitis
yellow-white patches of retinal opacifications, and retinal hemorrhage pts usually asx
tx of cmv retinitis
ganciclovir or foscarnet
vision defect in hypperosmolar hyperglycemic diabetic coma pathophysiology
blurry vision from hyperosmolarity
dacrocystitis
infection of lacrimal sac from obx at nasolacrimal duct --> pain, swelling, tenderness, rednessexpression of mucous or pus
sx in optic neuritis
central scotoma afferent pupillary defect changes in color perception decreased visual acuity
clinical findings of htn retinopathy
av nickeingcopper/silver wiringexudateshemorrhage no sx of visual impairment
pathophys of htn retinomapthy
focal spasm of arterioles, progressive sclerosis and narrowing
types of dm retinopathy
1. microaneurysms, hemorrhage, exudates, retinal edema --> vision changes2. pre-proliferative changes (cotton wool spots) 3. Prolferative (newly formed bv)

how can complications of dm retinopathy be prevented

with laser photocoag