5/31/13

Front 1

mechanism of destruction in idiopathic thrombocytopenic purpura (ITP)

Back 1

IgG antibodies to platelet glycoproteins gpIIb-IIIa or gpIb-IX coat both endogenous and exogenous (transfused) platelets (Type II hypersensitivity)
the coated platelets are removed in the spleen

Front 2

6 disorders producing thrombocytopenia

Back 2

1 idiopathic thrombocytopenic purpura (acute and chronic)
2 Neonatal alloimmune thrombocytopenia
3 post-transfusion purpura
4 heparin induced thrombocytopenia
5 thrombotic thrombocytopenic purpura
6 hemolytic uremic syndrome

Front 3

acute vs chronic ITP epidemiology

Back 3

acute is most common thrombocytopenia in children (2-6yo)
chronic is most common thrombocytopenia in adults (female 20-40yo)

Front 4

acute vs chronic ITP onset

Back 4

acute- abrupt onsent 2-4 weeks following viral infection
chronic- insidious onset

Front 5

acute vs chronic ITP treatment

Back 5

acute- corticosteroids
chronic- splenectomy (source of Ab and destruction); less responsive to corticosteroids

Front 6

7 categories- causes of interstitial pulmonary fibrosis (chronic restrictive lung disease)

Back 6

1 pneumoconiosis- silica, coal workers, asbestos, berylliosis,
2 drugs- bleomycin, busulfan, nitrofurantoin, methotrexate
3 sarcoidosis
4 idiopathic pulmonary fibrosis
5 collagen vascular disease- systemic sclerosis, SLE, rheumatoid arthritis
6 hypersensitivity pneumonitis- farmer's lung, silo filler's disease, byssinosis
7 radiation

Front 7

types of hypersensitivity pneumonitis
(note- hypersensitibity pneumonitis is NOT IgE mediated)

Back 7

1 farmer's lung- exposure to Saccharopolyspora rectivirgula (thermophillic aspergillis) in moldy hay
2 silo filler's disease- exposure to gases (oxides of Nitrogen)
3 byssinosis- in textile industry exposure to gram- bacteria on cotton

Front 8

farmer's lung mechanism

Back 8

exposure to thermophillic aspergillis in moldy hay
1st exposure- precipitating IgG antibodies in serum
2nd exposure- IC complexes (type 3 hypersensitivity)
chronic exposure- granulomatous inflammation (type 4 hypersensitivity)

Front 9

pathogenesis of sarcoidosis

Back 9

CD4+ T cells interact with unknown antigen and release cytokines causing granulomatous inflammation
Sarcoidosis is a diagnosis of exclusion

Front 10

causes of restrictive lung disease

Back 10

1 chest wall disorders in the presence of normal lungs- kyphoscoliosis, pleural disease (mesothelioma), obesity
2 acute interstitial disease- ARDS
3 chronic interstitial disease

Front 11

causes of oral leukoplakia (a premalignant lesion that can give rise to squamous cell carcinoma)

Back 11

1 tobacco (pipe smoke, tobacco chewing)
2 alcohol (less strong association than tobacco)
ill-fitting dentures

Front 12

presentation of hairy leukoplakia

Back 12

glossitis with BILATERAL white excrescences on lateral borders of tongue

Front 13

hairy leukoplakia associations

Back 13

EBV
pre-AIDS defining lesion- 200-500 CD4+ count

Front 14

oral manifestations of HIV

Back 14

Candidiasis- most common
hairy leukoplakia- bilateral lateral tongue
apthous ulcers- canker sores
kaposi sarcoma (hard palate)

Front 15

causes of glossitis (inflammation of the tongue)

Back 15

1 long standing iron deficiency
2 B12/folate deficiency
3 scurvy
4 pellagra (niacin)
5 scarlet fever
6 hairy leukoplakia (EBV)