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32 Cards in this Set

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what are the distinguishing characteristics of Corynebacterium diphtheria?
gram positive, rod shaped, not acid fast, non-spore-former, blue or touidine blue
Club shaped and posses metachromatic granules
what type of bacteria appears as Chinese letters in smears?
Corynebacterium diphtheria
appears as palisades in smears
what type of respiration does the Corynebacterium diphtheria use?
Facultative aerobe
under what conditions does a facultative aerobe grow best?
Facultative aerobes grow best aerobically
what is the antigenic structure of the toxins produced by Corynebacterium diphtheria?
toxins produced are immunologically identical
what controls the toxin production of the Corynebacterium diphtheria?
phage gene (tox gene)
Long chain fatty acids, capsular antigens, neuraminidase, and N-acetyl-neuraminidase are virulence factors for what bacteria?
Corynebacterium diphtheria
what does C. diphtheria break down for energy?
Mucous
what is the major determinant of disease caused by C. diphtheria?
Exotoxin
what type of exotoxin is released from C. diphtheria?
Lysogeny and tox gene
it is a classic A-B exotoxin which catalyzes ADP-ribosylation of Elongation Factor-2
it is estimated that one tox molecule can inactivate entire EF2 content of cell
how is C. diphtheria treated?
antibiotics, antisera, and supportive care
how many antigenic types of c. diphtheria are there?
1 antigenic type
what does the Elek plate test that is done in vitro tell us?
whether the tox gene is present or not
what causes Acne and cutaneous lesions?
Corynebacterium acnes
why is C. parvum used in chemotherapy?
Clostridium parvum is used in chemotherapy to elicit nonspecific cell mediated immunity response
what is the etiological agent for erythrasma?
C. minutissimum
The Group JK of Corynebacterium are rare in healthy people. What type of patient are they found in?
common in neutropenic patients, malignancies, IV entry sites, long term chemotherapy, and endocarditis
what is a distinguishing feature of Group JK of Corynebacterium?
Lipophilic and Coccobacillary
What is used to treat a Group JK of Corynebacterium infection?
Vancomycin because it is highly resistant to most antibiotics
what is the one Gram positive bacteria that has ENDOTOXIN?
LISTERIA MONOCYTOGENES
What type of disease is caused by Listeria monocytogenes?
Neonatal sepsis or meningitis
Granulomatosis infant septicemia
-can cross placenta
Can cross BBB
why is Listeria monocytogenes called a facultative intracellular organism?
because it can survive either outside or within the cell
what type of cells do Listeria monocytogenes invade and live in?
Intracellular parasite of macrophages, monocytes, can move in and out of cell
besides neonates who else is likely to be affected by a Listeria monocytogenes infection?
compromised patients with a 40-50% mortality rate
How is Listeria monocytogenes identified clinically?
simple media with added blood and CO2
microaerophillic
Blood, CSF are collected
Fluorescent antibody,serology, or animal test
what are the virulence factors of Listeria monocytogenes?
cold enrichment
O and H antigens
Several serogroups with one or multiple serovars
where do virulent strains of Listeria monocytogenes grow?
in monocytes
what type of disease is caused by Erysipelothrix?
occupational disease
it is common in shellfish, fish, animals, and fowl
what are some distinguishing characteristics about Erysipelothrix?
Gram + Rods
Where do Erysipelothrix grow best?
microaerophillic
best growth with 5-10% CO2
what other gram + bacteria does Erysipelothrix resemble?
Streptococcus
what is a clinical diagnostic for Erysipelothrix?
produces H2S
which is rare for Gram +