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13 Cards in this Set
- Front
- Back
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What is a hydatidiform mole?
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It is a nonviable implantation in the uterus. Trophoblastic proliferation, cystic villous swelling of chorionic villi.
Can precede choriocarcinoma |
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What do hydatidiform moles secrete that can be used as a tumor marker?
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hCG in abnormally elevated levels.
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What does a complete mole come from?
How many chromosomes? |
Androgenesis. Paternal DNA ONLY. 1 or 2 sperm get in.
46 chromosomes. 2% go on to choriocarcinoma |
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Where does a partial mole come from?
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Partial mole comes from dispermy (1 or 2 sperm and maternal contribution.)
69 chromosomes. RARE transofmration to choriocarcinoma. |
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How/when do complete moles present?
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2nd trimester. Painless bleeding.
ABNORMALLY HIGH hCG. |
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What is the tumor type of choriocarcinoma?
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Aggressive, invasive. Highly responsive to chemo.
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Which are the two routes of infection for placental infection?
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Hematogenous route or ASCENDING (main)
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Which type of organism is more likely to cause ASCENDING PLACENTL INFECTION?
What type of inflamm. response results after ASCENDING PLACENTAL INFECTION |
Bacteria and some candida.
Chorioamnionitis. |
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What is the response type of hematogenous PLACENTAL INFECTION?
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Villitis (makes sense because blood enters through villous)
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What organisms prefer hematogenous spread?
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VIRUSES (think enveloped).
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What happens if there is thrombosis into placenta?
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Ischemia of placenta which abrupts nutrient/blood/oxygen flow to fetus.
Reults in stunt or death |
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What is a potential sequelae to maternal hypertension during pregnancy in relation to placenta?
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Rupture of a retroplacental (decidual) blood vessel can cause separation of placenta from blood supply and result in PLACENTA ABRUPTIO
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hCG is greatly elevated in what two types of placental abnormalities?
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Hydatidiform moles and choriocarcinoma
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