3_17 Step Studying Cards

Front 1

source of secretin

Back 1

S cells in duodenum

Front 2

action of secretin

Back 2

increases pancreatic HCO3- secretion, decreases gastric acid secretion and decreases bile acid secretion

Front 3

regulation of secretin

Back 3

secreted when acid or fatty acids in duodenum

Front 4

causes of anion gap metabolic acidosis

Back 4

MUDPILES
methanol
uremia
diabetic ketoacidosis
paraldehyde/phenformin
iron/isoniazid
lactic acidosis
ethylene glycol
salicylates

Front 5

Burkitts genetics

Back 5

t(8,14) c-myc to IgG heavy chain

Front 6

mantle cell lymphoma genetics

Back 6

t(11,14)

Front 7

Follicular Lymphoma genetics

Back 7

t(14,18)
bcl2 expressed decreasing apoptosis

Front 8

significance of t(15,17)

Back 8

M3 type of AMP that responds to all-trans-retinoic acid therapy

Front 9

CML genetics

Back 9

t(9,22) bcr-abl Philly chromosome

Front 10

Ewing Sarcoma genetics

Back 10

t(11,22)

Front 11

TdT + ?

Back 11

marker of pre-B and pre-T cells

Front 12

Heparin: MOA, use, labs?

Back 12

MOA: cofactor for antithrombic activation to decrease sthrombin and Xa
used for pulmonary embolus anticoagulation, stroke, acute coronary, MI, DVT, anti-coag in PREGNANCY
LAB: PTT - intrinsic

Front 13

SE of Heparin use?
Tx?

Back 13

bleeding, HIT, osteoperosis
protamine sulfate rapidly reverses

Front 14

Low MW heparin pros? cons?

Back 14

pros: longer half life, more action on Xa, better bioavailability, given SQ w/o lab monitoring
con: NOT EASily reversible

Front 15

HIT - MOA, Tx?

Back 15

Heparin binds platelets --> AutoAb produced-->destroys and activates platelets
Tx: Protamine sulfate then Lepirudin and bivalirudin to inhibit thrombi

Front 16

thrombolytic MOA
Toxicity Tx?

Back 16

aids plasminogen --> plasmin to cleave thrombin and fibrin
Tx OD w/ Aminocarproic acid

Front 17

first line for testicular tumors that complexes iron and produces superoxide to attack DNA bonds

Back 17

bleomycin

Front 18

enhances tubulin polymerization = arrest in anaphase

Back 18

paclitaxel

Front 19

major functions of alpha one receptor (3)

Back 19

increase contraction of:
vascular smooth muscle
pupillary dilator
intestinal and bladder sphincter

Front 20

major functions of alpha two receptor (2)

Back 20

decreases sympathetic outflow and decreases insulin release

Front 21

TdT + ?

Back 21

marker of pre-B and pre-T cells

Front 22

Heparin: MOA, use, labs?

Back 22

MOA: cofactor for antithrombic activation to decrease sthrombin and Xa
used for pulmonary embolus anticoagulation, stroke, acute coronary, MI, DVT, anti-coag in PREGNANCY
LAB: PTT - intrinsic

Front 23

SE of Heparin use?
Tx?

Back 23

bleeding, HIT, osteoperosis
protamine sulfate rapidly reverses

Front 24

Low MW heparin pros? cons?

Back 24

pros: longer half life, more action on Xa, better bioavailability, given SQ w/o lab monitoring
con: NOT EASily reversible

Front 25

HIT - MOA, Tx?

Back 25

Heparin binds platelets --> AutoAb produced-->destroys and activates platelets
Tx: Protamine sulfate then Lepirudin and bivalirudin to inhibit thrombi

Front 26

thrombolytic MOA
Toxicity Tx?

Back 26

aids plasminogen --> plasmin to cleave thrombin and fibrin
Tx OD w/ Aminocarproic acid

Front 27

first line for testicular tumors that complexes iron and produces superoxide to attack DNA bonds

Back 27

bleomycin

Front 28

enhances tubulin polymerization = arrest in anaphase

Back 28

paclitaxel

Front 29

major functions of alpha one receptor (3)

Back 29

increase contraction of:
vascular smooth muscle
pupillary dilator
intestinal and bladder sphincter

Front 30

major functions of alpha two receptor (2)

Back 30

decreases sympathetic outflow and decreases insulin release

Front 31

major functions of beta one receptors (4)

Back 31

increase HR
increase contractility
renin release
lipolysis

Front 32

major functions of beta two receptors (7)

Back 32

vasodilation, bronchodilation,
increased: HR, contractility, lipolysis and insulin release
decreased uterine tone

Front 33

major functions of muscarinic type i receptor (2)

Back 33

CNS and enteric nervous system decreases

Front 34

major functions of type II muscarinics? (2)

Back 34

decrease HR and aortic contractility

Front 35

major functions of M3 receptors (6)

Back 35

basically responsible for all the non-heart PNS activity
increase: exocrine secretion, gut peristalsis, bladder contraction, bronchoconstriction, pupillary sphincter (miosis), ciliary muscle contraction (accomodation)

Front 36

D1 receptor functions?

Back 36

relaxes renal vasculature smooth muscle

Front 37

D2 receptor effects?

Back 37

modulate transmitter release

Front 38

H1 effects (4)

Back 38

increase nasal/bronchial mucus
contracts bronchioles
increases pruritus
increases pain

Front 39

H2 effects

Back 39

increases gastric acid

Front 40

V1 effect

Back 40

increased vascular smooth muscle constriction