38Liver, Pancreas And Spleen

Front 1

Alcoholic Liver Disease:
Common malady in Western society.
Three major phases: ___

Back 1

1. Fatty liver [one binge drinking session, these will reverse]
2. Alcoholic hepatitis
3. Cirrhosis

Front 2

Fatty Liver:
-What stage of what disease?
All chronic alcoholics accumulate fat within their liver cells.
-Liver can attain ___ times normal weight.
-___hepatocytes are first affected.
-With cessation of drinking, it is ___ and has few functional consequences.
e.g. after one night of binge drinking

Back 2

-1st stage of alcoholic liver disease
-three
-Centrilobular
-reversible

Front 3

Alcoholic Hepatitis:
-What stage of what disease?
More severe than fatty liver.
Alcoholic hepatitis presents a significant mortality.
It is an inflammatory, necrotizing disease.
-There is a ___ inflammatory response and necrosis of hepatocytes in the ___

Back 3

-2nd stage of alcoholic liver disease
-neutrophilic
-central zone (Zone 3, around the central vein).

Front 4

Cirrhosis:
-What stage of what disease?
-A scarring of the liver which can lead to ___ and/or ___
-Histologically, ___ form around hepatocellular nodules.
The normal structure and consequent function of the liver is disturbed.
Cirrhosis of the liver can have causes other than alcoholism.

Back 4

-3rd stage of alcoholic liver disease
-portal hypertension
-liver failure
-fibrous septa
s. 26

Front 5

Cardiac Cirrhosis:
Heart failure can cause liver damage that can lead to cirrhosis.
Hepatocytes in zone 3 that normally receive the least oxygen and nutrients, are very susceptible to ___ & ___
No noticeable changes are seen in zones ___.

Back 5

-ischemia and hypoxia
1 and 2
s. 27