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27 Cards in this Set
- Front
- Back
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MOA of class I A (eg. Procainamide), class IB (eg. Lidocaine), and class IC (eg. Flecainide) antiarrhythmics
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Sodium channel blockers
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SE of procainamide
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Lupus-like syndrome
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Limiting side effect of Quinidine
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Prolongs QT interval
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Other side effects of Quinidine
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Thrombocytopenic purpura, and CINCHONISM
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Major drug interaction with Quinidine
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Increases concentration of Digoxin
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DOC for management of acute ventricular arrhythmias
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Amiodarone
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DOC for digoxin induced arrhythmias
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Phenytoin
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SE of phenytoin
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Gingival hyperplasia
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Class of anti-arrhythmics that has a pro-arrhythmic effect (CAST trial), therefore are used as last line agents
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Class IC (flecainide, propafenone, moricizine)
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Class II antiarrhythmics are
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B-blockers
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Antiarrhythmic that exhibits Class II and III properties
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Sotalol
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Side effect of sotalol
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prolongs QT and PR interval
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Used intravenously for acute arrhythmias during surgery
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Esmolol
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Anti-arrhythmics that decrease mortality
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B-blockers
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MOA of class III antiarrhythmics
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Potassium channel blockers
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Class III antiarrhythmic that exhibits properties of all 4 classes
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Amiodarone
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Specific pharmacokinetic characteristic of amiodarone
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Prolonged half-life, up to six weeks
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Antiarrhythmic effective in most types of arrhythmia
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Amiodarone
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SE of Amiodarone
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Cardiac dysfunction, photosensitivity, skin (blue smurf syndrome), Pulmonary fibrosis, thyroid and corneal deposits
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MOA of class IV antiarrhythmics
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Calcium channel blockers
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Life threatening cardiac event that prolong QT leads to
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Torsades de pointes
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Agent to treat torsades de pointes
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Magnesium sulfate
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Drug used supraventricular arrhythmias
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Digoxin
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DOC for paroxysmal supraventricular tachycardia (PSVT)
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Adenosine
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Adenosine's MOA
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Activattion on an inward K+ current and inhibition of Ca++ current resulting in marked hyperpolarization
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Anti-arrhythmic with 15 second duration of action
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Adenosine
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DOC for paroxysmal supraventricular tachycardia; has high efficacy and short duration of action
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Adenosine
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