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12 Cards in this Set
- Front
- Back
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What is the MOA of antiviral drugs?
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triphosphorylated, used in DNA and RNA synthesis, interfere w/ viral DNA synthesis and/or viral transcription
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What is the MOA of amantadine?
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uncoat of the virus, bind to influenza A's M2 matrix, treat influenza (prophylaxis)
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What is the MOA of interferon?
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inhibits viral RNA translation and induces MHC-1 expression
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What do you use interferon for?
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chronic hep B and C, hairy cell leukemia
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What do you give to someone has chronic Hep C?
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pegulated interferon & ribavirin
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What drug do you give to the herpes viridae family? (includes HSV 1, HSV 2, VZV, EBV)
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acyclovir, DNA synthesis inhibitor , requires thymadine kinase (doesn't work on CMV). Vidarabine, imitates ATP
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What drugs do you give for CMV?
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Ganciclovir and Foscarnet
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What are NRTIs?
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AZT, didanosine, stavudine (d4T), lamivudine (3TC)
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What is part of the HAART regimen?
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NNRTI, protease, NRTI
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What are protease inhibitors?
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saquinavir, ritonavir, indinavir, nelfinavir, fosamprenavir, inhibits cleavage of "giant" protein (gag-pol-env), HIV must cut for certain components
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What are the NNRTIs?
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nevirapene, delavirdine, efavirenz
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What is DOC for CMV retinitis?
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valganciclovir, ganciclovir, cidofivir (alternative, very potent, adminster w/ probencid
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