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83 Cards in this Set

  • Front
  • Back
Where is the axon hillock located?
on the cell body right where the axon begins.
What is the function of sensory neurons?
they receive information from the environment.
What is the function of motor neurons?
to control movement of muscles and control secretion of glands.
What is the function of interneurons?
to receive information from other neurons. They integrate the information.
Where does the action potential start?
at the Junction of the axon with the soma.
Is action potential a chemical or electrical event?
it is both a chemical and an electrical event.
What happens when the action potential reaches the end of the terminal buttons?
it releases a chemical neurotransmitter.
What 2 that types of responses to action potentials promote?
excitatory or inhibitory.
What is normal resting membrane potential?
minus 70 mV.
Re: resting membrane potential, which that is positive and which side is negative?
negative inside, positive outside.
When thinking about resting membrane potential, what is action potential?
it is disturbance in resting membrane potential.
What is the threshold of excitation?
the membrane potential at which the action potential disturbance will occur.
Where are electrical synapse is found?
all cold
blooded animals, as well as in humans in our neurological system and hormonal system.
Through which part of the cell does propofol cause acidosis?
the mitochondria.
What is another name for electrical synapse?
electrical mechanical synapse.
Which gap junctions are tight?
electrical.
In which direction does the current travel with tight gap electrical junctions?
it can travel either way.
What passes through the gap junctions with electrical mechanical synapses?
current carrying ions.
What is the distance of the gap junction?
3.5 nm.
What is the pattern of electrical activity with electrical mechanical synapse?
it is synchronized. It is in the circadian rhythm.
Which type of neurons in our body operate by electrical mechanical synapse?
hormone secreting neurons.
How fast does signaling occur with electrical mechanical synapses?
0.2 ms. This is very quick.
What happens with signal transduction in the electrical synapse?
there is a voltage change (an ionic change of 1 of the cells, it can be either presynaptic or postsynaptic) of one of the cells, which allows exchange of ions to occur.

this can go in either direction.
What is the medium for signal transduction with chemical synapse is?
neurotransmitters.
What is the distance of chemical synapses?
20 to 40 nm.
How fast is signaling with chemical synapses?
2 ms.
Describe the mechanism of how the neurotransmitter works in chemical synapses:
the neurotransmitter spills into the synapse, moving onto a receptor on the postsynaptic site.

this causes either on excitatory response or an inhibitory response.
What is needed for the neurotransmitter to spill into the synaptic cleft with chemical synapses?
calcium.
What does the vesicle do when calcium interacts with it?
it docs onto the presynaptic membrane and spills its contents into the cleft. Then, in turn, the neurotransmitter attaches to a channel, which allows sodium to enter the postsynaptic neuron.
What is the major neurotransmitter in the spinal cord?
glycine.
What else happens with the neurotransmitter when it attaches to the receptor on the postsynaptic membrane?
there is some degradation of the neurotransmitter.
Which neurotransmitter is the excitatory neurotransmitter?
glutamate.
What happens in the postsynaptic neuron when there is an excess of excitatory glutamate?
the postsynaptic neuron is depolarized and more likely to generate an action potential.
Describe what happens with head trauma patients and neurotransmitter:
head trauma patients have an excess release of glutamate. This sets them up for a vicious cycle of damage. We want to prevent the excitatory response, so we can prevent more damage with neurological insult.

our goal is to stop the process from occurring.
What is the number one inhibitory neurotransmitter?
GABA.
What effect does GABA have on the postsynaptic neuron?
the neuron is hyper polarized. It is less likely to generate an action potential.
What happens with excitatory postsynaptic potentials?
depolarization. There is promotion of action potentials.
What happens with inhibitory postsynaptic potentials?
hyper polarization. There is prevention of action potentials.
What are the three types of postsynaptic binding sites?
sodium channel, potassium channel, and chloride channel.

plus, calcium channel is presynaptic. It helps to promote action potentials.
Which ion is entering the channel with excitatory synapses?
sodium.
Which ion is entering the channel with inhibitory synapses?
chloride.
When looking at an MRI, what is the best way to evaluate the ventricles and ventricular size?
look at the transverse plane view.
Describe development of the central nervous system in early embryonic life:
the central nervous system is a hollow tube. Parts of the tube begin to elongate.
At which time does the nervous system in embryo begin to develop?
on the 18th day after conception.

ectoderm thickens and forms a plate.

by the 21st day, the ridges touch each other and fused together, forming the neural tube. This gives rise to the brain and spinal cord.
Describe the central nervous system, 28th day of embryonic life:
the neural tube is closed.

the rostral end has developed three interconnected chambers. These chambers become the ventricles. The tissue that surrounds them becomes the three major parts of the brain (forebrain, midbrain, hindbrain.)
In the embryo, what does the forebrain develop into?
the telencephalon and diancephalon.
What 4 structures are contained in the telencephalon?
lateral ventricles.

cerebral cortex.

basal ganglia.

limbic system.
What 3 structures are contained in a diancephalon?
third ventricle.

thalamus.

hypothalamus.
In the embryo, what does the midbrain develop into?
the mesencephalon.
What is contained in the mesencephalon?
cerebral aqueduct.

tectum.

tegumentum.
In embryo, what does the hindbrain develop into?
metencephalon and mylencephalon.
What is contained in the metencephalon?
the fourth ventricle, the cerebellum, and the Pons.
What is contained within the myelencephalon?
the medulla.
Where is the limbic cortex located?, and what is its significance?
it is located within the limbic system. If there is hypo perfusion, there will be memory loss as a result of damage to this area.
What is the role of the hippocampus?
to convert short
term memory to long
term memory.
What is the role of the amygdala?
it is located in the limbic system. It helps manage emotional status.
What is the structural function of gyri and fissures?
they increase the surface area of the cortex. The more surface area we have, the more synapses we have.
Name the sensory organs of the cerebral cortex:
primary visual cortex.

primary auditory cortex.

primary somatosensory cortex.
What is the function of the primary visual, auditory, and somatosensory cortex?
they receive visual, auditory, and sensory information, respectively.
Which part of the cerebral cortex is responsible for control of movement?
the primary motor cortex.
Name the parts of the brain which are named after their corresponding parts of the skull:
frontal lobe.

parietal lobe.

temporal lobe.

occipital lobes.
What is the frontal lobe responsible for?
executive functions, voluntary muscle actions, eye movements, and the motor aspects of speech.
Which lobe of the cerebral cortex is the somatosensory lobe?
the parietal lobe.
What is the temporal lobe responsible for?
processing of auditory stimuli, visual association, and language comprehension. Keep in mind, however, that the temporal lobe is not primarily responsible for visual association, rather, the occipital lobes is responsible for visual association.
What is the occipital lobes responsible for?
processing of visual stimuli.
What are the 2 language centers of the cerebral cortex?
Wernerkes and barochas.
What is the major role of the basal ganglia?
it is instrumental in controlling movement.
What part of the brain does Parkinson's disease affect?
the basal ganglia. The basal ganglia is instrumental in controlling movement.
What are the three parts of the basal ganglia?
the caudate nucleus, the putamen, and the global pallidus.
What are the symptoms of Parkinson's disease when the basal ganglia is affected?
weakness, tremors, rigidity of limbs, poor balance, difficulty in initiating movements.
What are the primary functions of the limbic system?
emotion, motivation, and memory.
Name the five parts of the limbic system:
the limbic cortex, the hippocampus, the amygdala, the fornix, and the mamillary bodies.
In the limbic system, what is the limbic cortex responsible for?
dopamine turnover.
In the limbic system, what is the hippocampus responsible for?
memory formation and learning (encoding of new information.)
In the limbic system, what is the amygdala responsible for?
regulation of the emotional behavior and appetite.
In the limbic system, what is the fornix?
it is bundles of axons that connect to hippocampus to the other parts of the brain.
In the limbic system, what are the mamillary bodies?
they connect the limbic system to the hypothalamus.
Is short term memory loss really memory loss?
no. It is actually inability to convert information from short term memory into long term memory.
What are the two most important structures in the diancephalon?
the thalamus and the hypothalamus.
What is the role of the thalamus?
it contains nuclei that project information to specific regions of the cerebral cortex and receive information from it.

it integrates and transmits sensory information to various cortical areas of the cerebral hemispheres.

there are lots of interneurons here. Information integrates and then transmits to the brain.
What is the hypothalamus mainly responsible for?
regulation of the autonomic nervous system and control of the anterior and posterior pituitary glands.
What does the hypothalamus consist of?
groups of nuclei.
What types of human functions does the hypothalamus regulate?
basic survival. Eating, fight or flight, survival.