Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
Yersinia
a. gram? shape? b. how does it grow in oxygen? c. how to culture? |
1. GNR
2. facultatively anaerobic 3. MacConkey or blood, 28C |
|
|
3 clinical syndromes of Yersinia
|
bubonic, septicemic, and pneumonic plague
|
|
|
Where is Plague found in the US?
|
Western and SW states, small rodents and animals that feed on them
|
|
|
Pathogenesis of Yersinia induced bubonic plague
|
Yersinia from rat fly bitten into a human --> goes to LN --> survive in mononuclear phagocytes, proliferate --> bubo --> disseminate in blood stream (shock, DIC, necrotic hemorrhage, gangrenous distal extremities)
|
|
|
Pathogenesis of septicemic plague
|
secondary = rupture of a bubo 00> shock, DIC, necrotic hemorrhagic lesions, prupuric lesions in distal extremities
Primary = febrile illness w/o buboes or pneumonic plague |
|
|
pathogenesis of Pneumonic plague
|
Inhaled yersinia --> pneumonia
symptoms after 2-4 dyas |
|
|
Patient is febrile and traveled to an area endemic for plague.
What should you do next? |
aspirate bubo --> gram stain, maconckey and blood agar
if pneumonic --> sputum culture/stain, contact public health! |
|
|
2 agents to treat plague
|
Streptomycin or tetracycline
|
|
|
Fracisella
a. gram? shape? b. how does it interact with oxygen c. where does it live |
a. GNR
b. facultatively anaerobic c. hardy (survives in soil and water, gorws with sufhydryl compounds |
|
|
2 biogroups of F. tularensis
|
1. type A (more virulent, seen in n. America)
2. type B |
|
|
-Ulcerated skin lesion with painful regional lymphadenoathy
-lymphadenopathy w/o skin ulcer -Typhoid w/o lymphadenopathy -Pneumonia -Conjunctivitis + cervical or preauricular lymphadenopathy -oropharyngeal these can all be sequelae of what? |
Fracisella infection
|
|
|
Fracisella
where is it endemic |
Missouri, Arkansas, etc.
Zoonotic - rodents, rabbits, hares |
|
|
pathogenesis of ulceroglandular tularemia
|
bacteria in skin from a papule --> ulcerates, bacteria move to regional LN --> grow in phagocytic cells --> disseminate (focal lesions)
|
|
|
How is pneumonic tularemia obtained
|
inhalatoin or hematogenous
|
|
|
Extremely infectious pathogen that should be seen as a threat to lab workers
|
tularemia
|
|
|
How can you diagnose tularemia?
what should you do if you see inhalational tularemia |
DFA
notify authorities (maybe bioterrorism) |
|
|
Treatment for tularemia
|
streptomycin, gentamycin
|
|
|
Brucella
a. gram, shape |
gram neg rod
|
|
|
Some clinical sequelae of Brucellosis
|
systemic infection
long lasting fevers, joint pain, depression, endocarditis |
|
|
Brucella
3 mechanisms in which it is transmitted to humans what happens once they enter body |
1. ingestion (unpasteurized goat cheese)
2. inhalation 3. entry through skin wounds Engulfed by PMNs --> survive in phagocyte --> reticuloendothelial system |
|
|
dx brucellosis
treat |
serology
doxycylicne + streptomycin OR doxycycline + rifampin |
