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20 Cards in this Set
- Front
- Back
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cyclosporine
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binds cyclophylin - inhibits calcineurin
prevents IL-2 expression and T-cell proliferation nephrotoxic |
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tacrolimus
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binds FK-BP-12- inhibits calcineurin
prevents IL-2 expression and T-cell proliferation nephrotoxic topical use |
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sirolimus
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binds FK-BP-12 -- inhibits mTOR
inhibits IL-2 induces T, B cell proliferation increases TG and cholesterol, myelosuppression |
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everolimus
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binds FK-BP-12 -- inhibits mTOR
inhibits IL-2 induces T, B cell proliferation increases TG and cholesterol, myelosuppression |
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azathioprine
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purine anti-metabolite - mercaptopurine prodrug
leukopenia, GI tox metabolized by xanthine oxidase - don’t give w/ allopurinol |
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mycophenolate mofetil
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inhibits iosine monophosphate dehydrogenase (de novo purine synthesis)
leukopenia, GI tox decreased absorption w/ antiacids |
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prednisone
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inhibits T cell proliferation and cytokine expression
NO bone marrow toxicity |
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anti-thymocyte globulins
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induction agent - deplete thymocytes
foreign protein - fever |
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muromonab
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anti-CD3 - deplete T cells and reduce their function
prevent acute rejection allergy - obsolete |
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daclizumab
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anti-CD25 - specific for activated T cells
inhibit IL-2 induced T cells |
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inflixamab
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anti-TNF
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ramicade
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anti-TNF
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etanercept
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contains ligan binding portion - competes for TNF binding - not an Ab
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colchicine
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prevents tubulin polymerization and leukocyte migration & phagocytosis
familial mediterranean fever at high doses diarrhea and lethal |
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indomethacin
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NSAID - inhibits COX and crystal phagocytosis
alt to colchicine in initial tx |
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oxaprozin
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NSAID - inhibits COX and crystal phagocytosis
increases exretions - don’t use for pt w/ stones |
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probenecid
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uricosuric - organic acid, decreases reabsorption of uric acid
not for pt with huge amounts of uric acid -> stones begin 3wks after acute attack |
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sulfinypyrazone
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uricosuric - organic acid, decreases reabsorption of uric acid
not for pt with huge amounts of uric acid -> stones begin 3wks after acute attack |
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allopurinol
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suicide inhibitor of xanthine oxidase
blocks hypoxanthine -> xanthine -> uric acid better for chronic tophaceous gout, renal impairment, & levels >1.1g |
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uloric
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xanthine oxidase inhibitor
initially increased flares |
