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20 Cards in this Set
- Front
- Back
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Chronic Lymphoproliferative Disorders:
________ proliferation of lymphocytes in blood, bone marrow Many disorders; CLL most important Occur only in ____ Long course; indolent but ______ |
Malignant
adults incurable |
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What condition is this?
small, mature lymphocytes (appear regular) = small lymphocytic lymphoma (same disorder) CD5+ marker Long but inexorable course |
Chronic Lymphocytic Leukemia
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CLL happens in older patients, it is asymptomatic or there is _____ infiltration
It is positive for B-cell (CD20) antigen and a T-cell antigen (which?) Negative for ___ |
organ (big spleen, lymp nodes in axilla)
CD5 TdT |
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In the lab, CLL would have elevated ___ count and hypo__________
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WBC
hypogammaglobulenima (plasma cells normally in marrow, but lose home so can't live anywhere to produce globulins) |
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CLL has what rearrangement that helps the cells prevent apoptosis?
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bcl-2
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Treatment for CLL is ________. You can reduce organomegaly as part of tx
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Conservative - standard chemo doesn't work because cells are not rapidly turning over like normal leukemia
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Prognosis for CLL depends on _____. Also the bone marrow ______ and chromosomal abnormalities. Mean survival 13 years, usually death by _______
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counts - if they are normal then it's pretty good
pattern - focal good, diffuse bad infection (low Ig counts) |
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Which condition is this?
very distinct cells Big spleen but no lymphadenopathy Pancytopenia TRAP M:F = 5;1 |
Hairy cell leukemia
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Why don't you see very many hairy cells out in the blood?
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They make fibrotic tissue that circles around them making it hard for the cells to get out into the blood.
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In what condition would you see 'chicken wire cells'?
All of this fibrosis leads to what condition? |
Hair cell leukemia, in the bone marrow. This is due to the fibrosis produced by the cells.
Pancytopenia - no room for white cells |
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TRAP stains uniquely positive for what cells?
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Hairy cells
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Hairy cell leukemia is positive for _-cell antigen (CD25, CD11c)
Negative for _-cell antigen, CD5 |
B-cell
T-cell |
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Hairy cell leukemia will result in pancytopenia usually, _______ at least
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monocytopenia
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What is the treatment for hairy cell leukemia?
Prognosis |
Chemo - new drugs can cure it
Good prognosis |
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Which condition is this?
Prolymphocytes Splenomegaly without Lymphadenopathy Rare Aggressive |
Prolymphocytic Leukemia
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Prolymphocytic leukemia is very aggressive (like acute leukemia). Splenomegaly without ______.
Very high ____ low Hb and _____ count |
lymphadenopathy
platelet - as disease replaces the marrow, Hb and platelet count and normal neutrophil count go down |
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In what condition would you see very condensed chromatin, but a big nucleolus?
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Prolymphocytic leukemia
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Which condition is this?
distinct lymphocytes T-cell Neutropenia Long survival |
Large granulated Lymphocyte Leukemia
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Which is the T cell lymphocytic leukemia??
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Large granulated lymhocyte leukemia
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Clinical features of LGLL are frequent infections due to severe _______, long survival. Modest increase in _____
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neutropenia
WBC |
