3 Gi Pharm

Front 1

H2 Blockers named

Back 1

for acid secretion
Tidines......cimetidine
rani, famo, niza

Front 2

H2 Blockers Moa uses

Back 2

the "tidines"
decr acid (NOT BASAL)
blocks Gs----cAMP----H/K atpases cascade
Partial antag of vagal acid(?)
uses---PU,G-itis,eso reflux(mild) part of H.pyl. triple therapy----a
DoA, and SEs only big diff between

Front 3

Cimetidine SEs

Back 3

**inhibits CYP450 3A4/2D6 ****
CNS pen.----Confuse (esp with renal Prob)
STEROID PROBS----antiandrogenic)= Gynecomastia (pain)
milk women
other tidines milder Se profile

Front 4

Antacids SE
Alum
Mg
Ca
Na

Back 4

Alum---need good renal
constipation,(Ca also) can get Al encephalopathy in dialysis patients
all cause hypokalemia
Ca-can get wierd hypercalcemia and met alkalosis
Al acidifies urine (decr aspirin secretion)
Na citrate is DOC (esp to avoid reflux in preg)

Front 5

drugs that help with the mucus

Back 5

Bismuth Subsalicylate
Misoprostol

Front 6

Misoprostol MoA
USES

Back 6

PGE1 analog---increases cytoprotection----increased mucus secretion
increased bicarn secretion
decreased acid prod(?)
(good for PU, prevent NSAID induced ulcers, MAINTAIN PDA)
induce labor

Front 7

PPI named

Back 7

PRAZOLES (ome, lanso,esomer,rabe)

Front 8

Omeprazole Moa

Back 8

irreversible block of H/K PUMP in parietal cells inhibits BASAL BASAL and gastric acid secretion
this is the GUY for PUD, GERD, ZE Syn, G-itis

Front 9

Misoprostol SEs

Back 9

PREG X-------stim uterine contraction,,,,abort..
and diarr,abd pain,flatu, endo bleed

Front 10

Omeprazole SEs

Back 10

headache nausea, diarr,
inhibits CYP450----
(increased warf,benzodiaz,Phenytoin)
decreased abs acid requi drugs

Front 11

Sucralfate Moa,indications,SEs

Back 11

in acid becomes crazy gel
GOOD for smokers****** Preg
Aluminum......not in renal probs
meeses with absorp of tons oral drugs
increased constipation

Front 12

Gastric emptying drugs

Back 12

Metoclopramide(+chol,-dop) also antiemetic (SE =steroid probs)
Cisapride(myenteric Ach--removed from market)

Front 13

diarrhea drugs mechanisms

Back 13

opioids,adsorbants,bind and coat,inhibit PGs, bind bile acids, somatostatin analogue,anti-5HT-3, pro-5HT-4(tegaserod)(IBS)

Front 14

diphenoxylate w/ atropine
uses, mOA, SE

Back 14

nonspecific antidiarrhea
Opioid and antichol (atrop min abuse)
SEs- constpation--can get TOXIC megacolon, interact with CNS depress (alcohol)
(avoid in Infectious of bowel wall, poison induced diarrhea, not recomended in kids (resp depression)

Front 15

Loperamide
mOA, uses, SE

Back 15

=immodium)
OPioids, slow motility,
uses-chr/acute infectious Diarrhea W/O BLOOD FEVER, + other chronic diarrhea ibs etc.
the most prompt and effective nonspecific
SE-big first pass(avoid w/ hepatic dys), lower cns than diphenoxylate, constipation main problem

Front 16

Opioids for diarrhea

Back 16

was DIPHENOXYLATE W/ATROPine and my LOPERAMIde

Front 17

adsorbants for diarrhea
named
moa
use

Back 17

kaolin,pectin ,methylcellulose, activated charcoal
adsorbs toxins bugs...plus coat and protect
.......also stops absorbe drugs

Front 18

Bismuth subsalicylate
use
mOA
SE

Back 18

pepto bismol
symptoms of diarrhea, prophylaxis of travelers
mOA- COAT protect, inh PGs =antiinflam,antisecrete, increased e-lyte absorb))
antimicrobial, part of H.P> triple therapy
SE- Const(impaction in old young) radiopaque, salicysm, dec abs. some drugs

Front 19

nsaids antidiarrhea properties
SE

Back 19

inhibit PGs-= -inflam,-motile,+ reabsorb fluid
Gi bleed, Salicylism (tinnitus,vomit,

Front 20

cholestyramine resins
moa
uses in diarrhea

Back 20

diarrhea due to increased BILE ACIDS in colon mild c.diff. (binds toxins)(metro and vanco preffered)
SE- with sucrose (dm caut,)
constipations, gritty poop, careful with crohns with strictures, may decrease folate

Front 21

Octreotide
mOA
uses

Back 21

HORMONAL diarrhea (good in carcinoid tomur)BUY time till figure out problem, good in HIV diarrhea
Somatostatin analog-inhibits release of many GI hormones
SE- inject pain flatu steatorrhea

Front 22

IBD drugs

Back 22

5-asa drugs Ol/Me/BAL sulfaSALAzine(this one also with antimicrobial), inh. AA cascade =anti INflam.
START LOW GO SLOW

Front 23

Sulfasalzine SEs

Back 23

for IBD
mostly common headache nausea
some allergic Rxs
oligasperm
hepatitis
rare sever blooddyscriasis

Front 24

drugs for Crohn's

Back 24

Infliximab
Budesonide

Front 25

Infliximab
use
SE

Back 25

mouse Ab to TNF-alpha
mod to sever crohn's, and RA
SE-Ab so think HYPERSENSITIVITY can get reaction reactivate TB********MUST PRETEST screne

Front 26

Budesonide
use
SE

Back 26

Crohn's
Systemic corticosteroid (more Gluco than Mineralo)
low bioavailable (GOOD stays in lumen)

Front 27

Tx IBS
Diarrhea
constipation

Back 27

dia-ALosetron (anti5ht-3) (in women)
COnst-tegaserod(pro5ht-4) (IN WOMEN)

Front 28

alosetron
uses
mOA
SEs

Back 28

Tx-diar pred IBS in WOMEN without anat/metab abnorm
5HT-3 antag-=inhibit secret/motil/affernet pain signals
SE-RESTRICTED ACCES DRUG NEED TO BY IBS CERTIFIED....OBSTRUCTS THE BOWEL,PERF,TOX.MEGACOLON,ISCHEMIA DEATH

Front 29

tegaserod--sE

Back 29

OFF MARKET FOR CV PROBS
INCREASED ABD SURGERY AND PAIN....ACTUALLY STILL USED OFF LABEL WHEN NO OTHER OPTION AVAILABLE

Front 30

BULK FORMING LAXATIVES

Back 30

CARBOXYMETHYLCELLULOSE,METHYLCELLULOSE,KARAYA GUM, PSYLLIUM HYDROPHILIC COLLOID(metamucil) CA POLYCARBOPHIL

Front 31

PSYLLIUM
MOA
SE
USES

Back 31

A GOOD BULK FORMING LAX (FIBER) DILUTE FOR FULL BENIFIT
CONTIPATION AND DIARRHEA(MILD) MGMT
SE-POSSIBLE ALLERGIC,BLOAT FLATULENCE WITH BULK (LESS WITH PSYLLIUM)
CAN DECR ABS OTHER DRUGS

Front 32

LAXATIVES WITH PAF ACTIVITY

Back 32

PLATELET ACTIVATING FACTOR
TISSUE DISTRUCTIVE
BISACODYL AND CASTOR OIL
(THEY HAVE NITRIC OXIDE ALSO)

Front 33

LAXATIVES WITH NITRIC OXIDE ACTIVITY

Back 33

BISACODYL AND CASTOR OIL
(THEY HAVE PAF ALSO)
CASCARA (MILD)SENNA

Front 34

BISACODYL
USE
MOA
SE

Back 34

FOR CONSTIPATION----RECTAL (1 HR) ORAL 6 HRS SOFT STOOL
SE-PAIN IF RECTAL, TISSUE DAMAGE (paf)
SE- TISSUE DAMAGE

Front 35

CASCARA
USE
MOA

Back 35

NO
MILD
SOFT 6 HRS

Front 36

CASTOR OIL
mOA
USE
SE

Back 36

OUCH
CONSTIPATIO....WATERY EVAC VERY FAST THOUROUGH
NO & PAF
CATHARTIC---CONV TO RICINDEIC ACID BY GUT FLORA
SE- TOO POWERFUL,ENeMA GOOD

Front 37

DOCUSATE
USE
MOA

Back 37

MARGINALLY EFFECTIVE
SOFT STOOL 1-2 DAYS
DETERGENT EMULSIFIES FAT, RETAIN FLUID
IN CA,K,NA FORMS

Front 38

SENNA
MOA
USE

Back 38

MORE POTENT THAN CASCARA..DISCONT W/ NORMAL
NO MECH
SENNA POD PHYSIOLOGIC IS BEST
NOT FOR EXTREME.....SOME HEPATOTOX

Front 39

SALINE CATHARTICS
Mg, K, Ca

Back 39

Mg most common
osmotic attract h2o
fast
DEhydration must give with tons water
mg, k not in renal dis
na not in HF edema (not used much)

Front 40

Mineral Oil
uses
SE

Back 40

good rectal for compaction
no TOLLERANCE good
SE---lipid pneumonia...stand for two hours
LYMPH nodes Inflamation( granulomas)
don't take with docusate(LN scene worse from bigtima absorption)

Front 41

Polyethylene glycol
use
mech
se

Back 41

Bowel cleansing agent
pretreat with metaclopramide for nausea.................
salt water osmotic scene
se---gross....gi distress
safe and hated

Front 42

Lactulose
uses
SE

Back 42

COnstipation
HEPATIC ENCEPHALOPATHY (OR CHRONIC PORTAL HTN) HELPS GET AMMONIA OUT OF BLOOD
SYNTHETIC DISSACHARIDE NON DIGESTED = OSMOTIC SCENE
SE- BACTERIAL OVERGROWTH, FLATULENCE, AVOID IN DM

Front 43

GALL STONE TX

Back 43

CHENODIOL URSODIOL
THESE ARE NATURAL BILE ACIDS-----DECREASE THE SATURATION INDEX
SHOCK WITH LITHOTRIPSY
CHENODIOL INCREASES AST

Front 44

PANCREATIC ENZYME REPLACEMENT

Back 44

NOT SUPPLEMENT--YES REPLACE
CAN HAVE ALLERGIC REACTION
TX STEATORHEA SCENE