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161 Cards in this Set

  • Front
  • Back
treat alcohol overdose with?
naltrexone
treat opiod overdose w/?
naloxone and natrexone
treat barituate overdose w/
fumazeinl
treat cocain overdose w/?
benzos
methyphenidate
inc catacholamines at cleft NE/doapmine
tx: ADHD, narcolepsy appetitie control MDD
amphetamines
inc catacholamines at cleft NE/doapmine
tx: ADHD, narcolepsy appetitie control MDD
atomoxetine
NOR reuptate inhib
treats ADHD
typical antipsychotic
block D2 inc cAMP
trets schizophrenia esp positive, demented, psychosis, mania tourette's
EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic)
EPS
acute hysponia (torticolus, mm spasm oculogyric crisis) 4hr treat w/ diphenhydramine
4d akinesia
4wk akanthesia restlesssness
4mo tardive dsykinesia irreversible
NMS
FEVER fever, encephalopahty vitals unstable elevated enzyems rigidity, mm spasms rphadomylosis
treat NMS
dantrolene and bromocritpine (endocrine)
dantrolene
treats malignant hyperthermia and NMS
excess mm contracton prevents release of Ca form SR of sk mm
anesthetics NO an dsuccinylcholine can cause
haloperidol
high potency (tourettes) few anticholinergic effects more EPS
ypical antipsychotic,
block D2 inc cAMP
trets schizophrenia esp positive, demented, psychosis, mania tourette's
EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic)
fluphenazine
high potency few anticholinergic effects more EPS
ypical antipsychotic,
block D2 inc cAMP
trets schizophrenia esp positive, demented, psychosis, mania tourette's
EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic)
trifuperazine
mod potency
few anticholinergic effects more EPS
ypical antipsychotic,
block D2 inc cAMP
trets schizophrenia esp positive, demented, psychosis, mania tourette's
EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic)
chlorpromazine
low potency w/ anticholinergic antihistmaine effects NOT give in elderly (derious) AZINE
ew anticholinergic effects more EPS
ypical antipsychotic,
block D2 inc cAMP
trets schizophrenia esp positive, demented, psychosis, mania tourette's
EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic)
thioridazine
low potency w/ anticholinergic antihistmaine effects NOT give in elderly (derious) AZINE
ew anticholinergic effects more EPS
ypical antipsychotic,
block D2 inc cAMP
trets schizophrenia esp positive, demented, psychosis, mania tourette's
EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic)
atypical antipsychotics
1st line blocks 5HT2, dopamine an dH1 receptors
best for negative symptoms
mania bipolar wieght gian DM
treat ADHD
methyphenidate, amphetamines, atomoxetine
treat tourettes
haloperidol
treat GAD
buspirone
treat OCD
SSRS clomipramine
treat bipolar disorder
lithium valproic acid, carbamazepine lamotripine antiseizure drugs AND atypical olanzapine aripiprazole
olanzapine
weight gain OCD anxiety depression mania toruettes
atypical antipsycotic
1st line blocks 5HT2, dopamine an dH1 receptors
best for negative symptoms
mania bipolar wieght gian DM
it is atypical for for old closets to quietly rister from A-Z
closapine
agranulocytosis must watch closely WBC motior
atypical antipsycotic
1st line blocks 5HT2, dopamine an dH1 receptors
best for negative symptoms
mania bipolar wieght gian DM
it is atypical for for old closets to quietly rister from A-Z
quetiapine
weight gain atypical antipsycotic
1st line blocks 5HT2, dopamine an dH1 receptors
best for negative symptoms
mania bipolar wieght gian DM
it is atypical for for old closets to quietly rister from A-Z
risperidone
MC given FIRST atypical antipsycotic
1st line blocks 5HT2, dopamine an dH1 receptors
best for negative symptoms
mania bipolar wieght gian DM
it is atypical for for old closets to quietly rister from A-Z
aripiprazole
atypical antipsycotic
1st line blocks 5HT2, dopamine an dH1 receptors
best for negative symptoms
mania bipolar wieght gian DM
it is atypical for for old closets to quietly rister from A-Z
ziprasodone
weight loss!
1st line blocks 5HT2, dopamine an dH1 receptors
best for negative symptoms
mania bipolar wieght gian DM
it is atypical for for old closets to quietly rister from A-Z
lithium
LMNOP mood stability treats biopolar blocks replase of acut mania
lithium , movement tremor, nephrogenic DI, hypOthyroidism, preg NO
ebseitn anomay malform great vessels ASD, small RV large RA displaced TV
low TI
SSRI
inhib serotonin reuptake
treats depression OCD anorexia social phobias
fluoxetine
longest HL
SSRI
inhib serotonin reuptake
treats depression OCD anorexia social phobias; 2-4 wks to work SE: sexual dysfuncti, GI distress serotonin syndrome mix SNRI MAOi
paroxetine
SSRI
inhib serotonin reuptake
treats depression OCD anorexia social phobias; 2-4 wks to work SE: sexual dysfuncti, GI distress serotonin syndrome mix SNRI MAOi
sertraline
SSRI
inhib serotonin reuptake
treats depression OCD anorexia social phobias; 2-4 wks to work SE: sexual dysfuncti, GI distress serotonin syndrome mix SNRI MAOi
citalopram
SSRI
inhib serotonin reuptake
treats depression OCD anorexia social phobias; 2-4 wks to work SE: sexual dysfuncti, GI distress serotonin syndrome mix SNRI MAOi
serotoinin syndrome
mix SNRI MAOi kava kava st john wart tryptophan cocain amphetamines ectasy cybutramine
HARM autonomc instability rigidity myoclonus hyperthermia diarrhea seizrues ocular clonus; give 5HT atnag cyporheptadine
treat serotonin syndrome
cyprohepadine
TCAs
block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn
SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly
give bicarb

***apropine like SE!!!
imipramine
bedwetting TCA
block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn
SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly
give bicarb
amitriptyoine
more SE TCA
block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn
SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly
give bicarb
desipramine
less sedation TCA
block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn
SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly
give bicarb
nortriptyline
less SE elderly okay TCA
block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn
SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly
give bicarb
clomipramine
OCD TCA
block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn
SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly
give bicarb
doxepin
TCA
block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn
SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly
give bicarb
amoxapine
block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn
SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly
give bicarb TCA
MAOi
MAOi of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists
phenelzine
MAOi of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists
tranycypromine
MAOi of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists
isocarboxazind
MAOi of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists
selegiline
MAOB for parkinsons
MAOB of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists
SNRI
inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression
venlafaxine
GAD SNRI
inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression
duloxetine
diabetic pierpheral neuropathy SNRI and depression
nefazodone
inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression
SNRI
milnacipran
fibromycalgia SNRI
inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression
sibutramine
wieght loss SNRI
inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression
buproprion
NDRI depression smoking cessation inc NE and dospmine sexual SE stim tach insomnia HA
lower seizure sthreshold in bulimics
mirtazapine
a2 antag inc NE and serotonix potent 5HT 2/3 antag
atypical depression toxic sedation inc appetite weight gain dry mouth
maprotiline
blocks NE reuptake toxicty sedaiton orthostatic hpotension
trazodone
inhib serotonin reuptake for insomnia inc REM atypical antidepressant high doses needed
SE pripaims sed postural hypotension
trazobone
buspirone
stim 5HT1 GAD no sed addiction or tolerance
no intereact w/ alcohol
class 1a antiarrythmics
police department questions; TORSADES
Na
procainamide, quinidne, disopyramide
inc AP duration (slow O prolong 3) inc ERP inc QT affect atiral and ventricular arrhythmias reentrant and ectopic SVT/V tach
class 1A-C antiarrythmic
the Police Department Question
The Little Man
For Pushing Extacy
Na Sodium-channel blockade:
IC > IA > IB
Increasing the ERP:
IA > IC > IB (decreases)
procainamide, disopyramide, quinidine
lidocaine tocainamide, mexiletine poss phenytoin
Flecainide, Propafenone, Encainide
class 1-4 type of drugs against?
Na, BB, K, CCB
procainamide
class 1A antiarrythimc TORSADES

Na; inc AP duration (slow O prolong 3) inc ERP inc QT affect atiral and ventricular arrhythmias reentrant and ectopic SVT/V tach
TREATS WPW! SE: drug induced lupus
disopyramide
class 1A antiarrythimc TORSADES

Na; inc AP duration (slow O prolong 3) inc ERP inc QT affect atiral and ventricular arrhythmias reentrant and ectopic SVT/V tach
quididine
cinchonism HA tinnitus TP TORSADES

class 1A antiarrythimc
Na; inc AP duration (slow O prolong 3) inc ERP inc QT affect atiral and ventricular arrhythmias reentrant and ectopic SVT/V tach
class 1B antiarrhytmic
The Little Man lidocaine, tocainide, mexilitine poss phenytoine (digitalis induced)
Na but dec AP duration decreases the rapid influx of sodium SO les refractory time SO poss arythmias
treats ISCHEMIC or depolized ventricular tissue
local anesthetic CNS inc CV depression
lidocaine
treats acute V tach; class 1b


The Little Man lidocaine, tocainide, mexilitine poss phenytoine (digitalis induced)
Na but dec AP duration decreases the rapid influx of sodium SO les refractory time SO poss arythmias
treats ISCHEMIC or depolized ventricular tissue
local anesthetic CNS inc CV SHORETED THE AP
mexiletine
class 1b

The Little Man lidocaine, tocainide, mexilitine poss phenytoine (digitalis induced)
Na but dec AP duration decreases the rapid influx of sodium SO les refractory time SO poss arythmias
treats ISCHEMIC or depolized ventricular tissue
local anesthetic CNS inc CV SHORETED THE AP
tocainide
class 1b; poss pulm fibrosis

The Little Man lidocaine, tocainide, mexilitine poss phenytoine (digitalis induced)
Na but dec AP duration decreases the rapid influx of sodium SO les refractory time SO poss arythmias
treats ISCHEMIC or depolized ventricular tissue
local anesthetic CNS inc CV SHORETED THE AP
class 1C
for pushing ecstacy flecainide, encaindide, propafone
only affects phase 0 not AP duraiton; treats V tach SVT
SE: inc refractory hyperK
class 2 BB
BB proppanolo and esmol dec cAMP dec Ca currents and suppress abnormal paceakers prolong phase 4 by blocking the SA/AV nodes prolong refractory and AP
inc PR
V tach SVt dec A fib/flutter
SE: impotence AV block, sedaiton sleep alt
treat w/ glucagon
flecainide
class 1c
for pushing ecstacy flecainide, encaindide, propafone
only affects phase 0 not AP duraiton; treats V tach SVT
SE: inc refractory hyperK
encaindide
class 1 c
for pushing ecstacy flecainide, encaindide, propafone
only affects phase 0 not AP duraiton; treats V tach SVT
SE: inc refractory hyperK
porpafenone
class 1 c
for pushing ecstacy flecainide, encaindide, propafone
only affects phase 0 not AP duraiton; treats V tach SVT
SE: inc refractory hyperK
class 3 anrythmic
K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone
TORSADES!
inc AP duration and ERP inc QT interval
amiodarone
treat SVT/Vtach
SE: pulm fiboriss, hepatotoxic, hypo/hyperthyroidism (iodine in it) corneal deposits skin deposits blue/gray skin; photodermatitis, neuro effects constpation CV brady heart block CHF check PFTs, LFTs, TFTs alters lipid membrane
inc AP duraiton inc ERT
in cQT interval torasaes (less than 1A and 3
sotalol
ventricular arrhythmias; atrial flutter and fibrillation

K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone
TORSADES!
inc AP duration and ERP inc QT interval
ibultilide
SVT arrhythmias; atrial flutter and fibrillation conversion

K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone
TORSADES!
inc AP duration and ERP inc QT interval
bretylium
new arrythmias and hypotension
treats: V tach and fib

K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone
TORSADES!
inc AP duration and ERP inc QT interval
dofetilide
K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone
TORSADES!
inc AP duration and ERP inc QT interval
arrythmics that cause torsade
1A, 3 and amiodarone
class 4 antiarrythmics
CCB verapamil --constipation and ginival hyperplasia and diltiazen
inc refractory period inc ERP inc PR dec conduction velocity prevent nodal arrythmias like SVT
slows SA/AV firing
adenosine
VD inc K out of cells hyperpolarize
dec Ica
treats PSVT
lasts 15s
AV block flush hyptoension CHEST PAIN theophyllin blocks
STRESS TEST
not used in WPW
what does Mg treat?
torsades and digoxin toxicity
HCT
treats hypertension
poss causes arrhythmias
HYPER: uricemia, glycemia, lipidemia, calcemia (treats stones less risk of osteoporosis)
avoid sulfa allergy
hypoK, hypotension poss
loop diuretics
calcium loosing; hyperuircemia; hypotension poss get rid of fluids
treats HTN

may cause ototoxicity (do not combine w/ aminoglcycosides) also sulfa allergy
BB
dec mortality AL inc EDV dec BP dec contracitlity dec HR inc ejection time dec MVO2
CI decomp CHF
ACEi
protect against diabetic nephroapthy b/c dilate eff; treats HTN and CHF inhib remodeling
SE: hyperK, ocugh taste problems inc renin
*dec risk of MI
SE: angioedema rash NOT GIVEN IN PREG (RENAL)
clonidine
A2 agonist centrally acting reboudn HTN
HL 8 hrs can cause bradycardia
methyldopa
can be given in preg treat HTN
sedation
+coombs
guanethidine
blocks NE release??
prazosin
a1 blocker treats HTN 1st dose orhtostatic HTN
hyralazine
treats HTN dilates arterioles vasodilator dec AL for SEVERE HTN CHF
can be given in PREG also give BB to prevent the reflex tach
SE: fluid rtn nause HA angina lupus like syndrome compensatory tach (CI in anigna CAD)
minoxidil
hypertricosis
K channel blocker severe HTN or renal disease RF
nifedipine
dihydropyridine vascular sm NOT the heart
HTn agnina prinzmetal's angina raynauds
SE: peripheral edema constipation reflex tach good w/ bradycardia
nitroprusside
malignant HTN short acting
inc cGMP direct relase of NO cyanide toxicity
fenoldopam
dopamine D1 recptor agonist
relaxes renal ascular sm
diazoxide
k channel opener hyperpolarizes and relaxes vascular sm
dec insulin release
HYPERLGYCEMIA
treats insulinoma
nitroglycerin
VD, release NO in sm; in cGMP sm relax VEINS dec PL
relfex tach hyptension flusing
HA
monday diseasee can get tolerance
dec EDV dev BP inc contractility as reflex; dec ejection time dec MVO2 used
combo w/ BB dec the HR dec MVO2
isosorbide dinitrate
VD, release NO in sm; in cGMP sm relax VEINS dec PL
relfex tach hyptension flusing
HA
monday diseasee can get tolerance
dec EDV dev BP inc contractility as reflex; dec ejection time dec MVO2 used
combo w/ BB dec the HR dec MVO2
digoxine
40HL, inhib Na/K atpase indirect Na/Ca exchanger inc Ca postive inotropy stim vagus
tx: CHF A fib slows conduction inc parasym tone in vagus
SE: cholinergic NV diarrhea chagne in color vision nausea anorexia inc PR de cQT scooping T wave inversion arrhythmias hyper K
wrosened by RF hypoK
give K, lidociane or phenytoin, cardiac pacer antidig Rab frag Mg
HTN drugs safe in preg 4
methyldopa labetolol hydrazoline nafetapine
statins
HMG COA reductase inhib
no CH
inc LFTs rhabdomyolysis
niacin
dec LDL inc HDL inhib lipolysis in adipose
dec hepatic VLDL secreiton
SE: flushed (give aspirin) hyperlgyc, hyperuricemia
bile acid resins
dec LDL prevent intestinal reabsorption of bile acids liver must use CH to make more
SE: tastes bad Gi discompfort dec fat solubel vit
CH gallstones
tx: C diff
cholestyamine
bile acid binding resins
dec LDL prevent intestinal reabsorption of bile acids liver must use CH to make more
SE: tastes bad Gi discompfort dec fat solubel vit
CH gallstones
tx: C diff
colestipol
bile acid binding resins
dec LDL prevent intestinal reabsorption of bile acids liver must use CH to make more
SE: tastes bad Gi discompfort dec fat solubel vit
CH gallstones
tx: C diff
colesevalm
bile acid binding resins
dec LDL prevent intestinal reabsorption of bile acids liver must use CH to make more
SE: tastes bad Gi discompfort dec fat solubel vit
CH gallstones
tx: C diff
ezetimibe
CH absopriton blocker
dec LDL
prevent CH reabosrtpion at SI brush border inc LFTs
fibrates
gemefibrozil clofibrate bezafibrate fenofibrate
dec TG upreg LPL
inc TG clearance
SE: myosistis hepatotoxic inc LFTs Ch gallstones
drugs that cuase urinary retention
antichol atropine, TCAs antihist
MTX
folid acid analog inhib dihydrofolate reductase dec dTMP decDNA and proteins syn similar to TMP
tx: leukemia lymphomas sarcoma , abortiopn ectopic preg RA psoriais
SE: myelosuppresion REV W/ LEUCOVORIN (folicinic acid); fatty liver, mucositis, teratogneic lung disease
5-FU
pyrimiding analog complexes w/ folic acid inhib thymidiylate synthase; dec TMP, protien syn
tx: clon cancer solid; Actinic keratosis topical; synergy w/ MTX
SE: myelosupp rescue w/ thymidine; photsn
6MP
pruine inhib PRPP synthetase ribose HGPRTase leukemia lymphomas
NOT CLL or HL
SE: BM, Gi Liver met by xanthine oxidase inc toxicity w/ allopurinol
thioguanine
same as 6MP treats ALL bm depression liver allopurinol ok
cytarabine ara C
pyrimidine antag inhib DNA polym
AML, ALL NHL
SE: luecopenia, TP megaloblastic anmia
cyclophosphamide
alkylating agens X linked DNa need bioactivation by liver
Tx: NHL wegener's breast ovarian carinomas, immunsuppressant z
E: mylosuppression, hemorrhagic cystotis, acroline toxic prevetns w/ MESNA
inc risk bladder cnacer
nitrosurease
car mustine lormustine
required bioact
BBB CNs brain tumors CNS toxicity (dizzy/ataxia)
busulfan
alk DNA
treat CML ablaste bm
before bm transplant
SE: pulm fibrosis hyperpig
carmustine
nitroureas
reaquired bioact
BBB brain tumors
CNS toxicity
cisplastin/carboplatin
xlink DNA testtiuclar bladder ovary lung
SE: npehrotox acoustic nerve damge (amin, vanco, loop))
dactinomycin
intercalacte in DNA
children-wilm ewings rhabdo children ACT out
SE: myelosupp cardiotoxic
doxorubin
gen FRs dna breaks dec replication
HL myelomas sarcoma, solid tumors
cardiotoxic dilated CM myelsypp aloepcia
bleomycin
FR formation breaks in DNA testicular cancer HL
SE: pulmonary fiboriss skinc hanges min myelosupp
hydroxyurea
treat sickle cell CML meanoma
inhib ribonucleotide reductase dec DNA
GI irritation alopecia
etoposide/teniposide
inhib topo 2 inc DNA deg small cel protate testicular cacnier
myelosupp
GI irritation alopecia
vincristine/ vinblastine
alkaloid prevetns assembly MT
HL wilm's choriocarcionma
blastine dec bM
crinistine neurtoxic and paralytic ileus
paclitaxel
inhb tubulin breakdown orvairna and breat
meylosupp/HS
tamoxifen
inc risk of endometrial carcinoma partiaSERM
agonist in bone block E Rcl agonist hot flasthes
raloxifene
antag endometrial cancer
SERM agonist in bone block E Rc
predinison
tirgger apoptosiss even nodivdin cells
CLL HL immunosupp AI
cushing like immunosupp cataract insomnia acne osteoporosis HTN PUD hyperglycemia pyschosis
trastuzumab
herceptin monoclonal antibody against HER-2 erb-b2 kill breast cancer
ab dep cytotoxic met breast cancer
SE: cardiotox
imitinib
abl TK inhib
CML ALL
GI stomal tumors
fluid tn
rituximab
monoclonal ab CD20 B cell NHL RA w/ MTX
treat testicular cancer
cisplatin belomycn etoposide
interferes w/ MTs
taxols bendazole griseofluvin colchicines vincrsitine/vinblastine
PTU
hyperthyroidism
inhib organification of iodid and coupling of TH syn; inhib tyrosal group
SE rash agrnaulocytosis aplastic anemia
dec peripheral conversion to T3 can be given in preg
methimazole
hyperthyroidism
inhib organification of iodid and coupling of TH syn; inhib tyrosal group
SE rash agrnaulocytosis aplastic anemia
TERATOGEN
levothyroxine
thryoxine replacemnt
tx: hypothyroidism myxedema
SE: tach eat intolerance tremor arrythmias
triiodothyroxine
thryoxine replacemnt
tx: hypothyroidism myxedema
SE: tach eat intolerance tremor arrythmias
octeotride
somatostatin-D cell sin gut/pancreas CNS dec endocrine and exocrin esec
dec splanchnic BF GI motility and Gb contraction inhib GI hormones,
tx: acromegaly, thyrotropinioma ACTH tumors ZE syndrome carcinoid syndrome, VIPoma cholera intesthypermobility, gucagonoma, insulinoma, diarrheal disease
portal HTN (varices) bleeding Pud
oxytocin
paraventricular nucleus
stim labor uterine contration smilk let down controls uterine hemorrhage
desmopressin
pituitary central DI and vWD treat
demeclocyline
ADH antag for siADH but can cause nephrogenic DI, photosn, bone/teeth abnormalities
--tetracycline
glucocorticoids
prenisolone for liver disease, hydrocortison prednisone tramicinolon
dexamethazone beclomthasone--long acting
dec prod of LT/PG inhib PLA2 and OCX2
tx: addison's disease inflammation immune suppresion asthma
SE: iatrogenic cushing's
sulfonylurieas
disulfiram effect, hypoglycemia, close K channels in B cell membrane so cell depolazises trigger insulin release via Cainfulx stim release fof insulin in T2DM
glyburide
sulfonylureas
disulfiram effect, hypoglycemia, close K channels in B cell membrane so cell depolazises trigger insulin release via Cainfulx stim release fof insulin in T2DM
glimepiride
sulfonylureas
disulfiram effect, hypoglycemia, close K channels in B cell membrane so cell depolazises trigger insulin release via Cainfulx stim release fof insulin in T2DM
glipizide
disulfiram effect, hypoglycemia, close K channels in B cell membrane so cell depolazises trigger insulin release via Cainfulx stim release fof insulin in T2DM
biguanides
metformin
dec lguconeogensis in liver inc glycolysis inc peripheral glc uptake insulin sn
oral
SE: LA,
CI: renal failrue liver, CHF no IV contrast, PCOS
okay in preg; WEIGHT LOSS don't have to tak ew/ meals used in combo lowers TG/CH
do not use in pt w/ inc Cr
monitor LFT's
glitazones
thiazolidinediones: pioglitazone, rosiglitazone (inc risk of MI)
inc insulin sn in peripheral tissue binds PPAR nuclear transcriton reg; monotherapy
SE: wieght gain edema, hepatotox
Cv tox
CI CHF monitor liver
can use in renal diseaes
a glucosidase inhibitor
inhib intestinal brush border, delayed sugar hydrolysis and abosrption; dec postprandial hyperglycemia; mono
GI dist
do not use in liver cirrhosis
inc Cr, IBD
acarbose
a glucosidase inhib
inhib intestinal brush border, delayed sugar hydrolysis and abosrption; dec postprandial hyperglycemia; mono
GI dist
do not use in liver cirrhosis
inc Cr, IBD
miglitol
a glucosidase inhib
inhib intestinal brush border, delayed sugar hydrolysis and abosrption; dec postprandial hyperglycemia; mono
GI dist
do not use in liver cirrhosis
inc Cr, IBD
pramlinitide
amylin analog mimetics
dec glucagon and gastric empying hypoglycemia
diarrhea postpradial hyperglycemia dec
GLP-1 analog
exenatide
inc insulin dec glucagon release T2DM sugQ N/V pancreatitis
excenatide
GLP-1
exenatide
inc insulin dec glucagon release T2DM sugQ N/V pancreatitis
stigaglipitin
incretin secreiton dec glucagon inc insulin delays gastric empying
orlastat
weight loss drugs inhib pancreatic lipases excrete fat
SE steatorrhea HA abdominal pain oily stool leakage