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161 Cards in this Set
- Front
- Back
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treat alcohol overdose with?
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naltrexone
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treat opiod overdose w/?
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naloxone and natrexone
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treat barituate overdose w/
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fumazeinl
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treat cocain overdose w/?
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benzos
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methyphenidate
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inc catacholamines at cleft NE/doapmine
tx: ADHD, narcolepsy appetitie control MDD |
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amphetamines
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inc catacholamines at cleft NE/doapmine
tx: ADHD, narcolepsy appetitie control MDD |
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atomoxetine
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NOR reuptate inhib
treats ADHD |
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typical antipsychotic
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block D2 inc cAMP
trets schizophrenia esp positive, demented, psychosis, mania tourette's EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic) |
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EPS
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acute hysponia (torticolus, mm spasm oculogyric crisis) 4hr treat w/ diphenhydramine
4d akinesia 4wk akanthesia restlesssness 4mo tardive dsykinesia irreversible |
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NMS
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FEVER fever, encephalopahty vitals unstable elevated enzyems rigidity, mm spasms rphadomylosis
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treat NMS
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dantrolene and bromocritpine (endocrine)
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dantrolene
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treats malignant hyperthermia and NMS
excess mm contracton prevents release of Ca form SR of sk mm anesthetics NO an dsuccinylcholine can cause |
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haloperidol
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high potency (tourettes) few anticholinergic effects more EPS
ypical antipsychotic, block D2 inc cAMP trets schizophrenia esp positive, demented, psychosis, mania tourette's EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic) |
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fluphenazine
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high potency few anticholinergic effects more EPS
ypical antipsychotic, block D2 inc cAMP trets schizophrenia esp positive, demented, psychosis, mania tourette's EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic) |
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trifuperazine
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mod potency
few anticholinergic effects more EPS ypical antipsychotic, block D2 inc cAMP trets schizophrenia esp positive, demented, psychosis, mania tourette's EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic) |
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chlorpromazine
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low potency w/ anticholinergic antihistmaine effects NOT give in elderly (derious) AZINE
ew anticholinergic effects more EPS ypical antipsychotic, block D2 inc cAMP trets schizophrenia esp positive, demented, psychosis, mania tourette's EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic) |
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thioridazine
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low potency w/ anticholinergic antihistmaine effects NOT give in elderly (derious) AZINE
ew anticholinergic effects more EPS ypical antipsychotic, block D2 inc cAMP trets schizophrenia esp positive, demented, psychosis, mania tourette's EPS, NMS, endocrine SE (hyperporlactinemia galactorrhea, amenorrhea dec libido antimuscarinic) |
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atypical antipsychotics
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1st line blocks 5HT2, dopamine an dH1 receptors
best for negative symptoms mania bipolar wieght gian DM |
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treat ADHD
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methyphenidate, amphetamines, atomoxetine
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treat tourettes
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haloperidol
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treat GAD
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buspirone
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treat OCD
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SSRS clomipramine
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treat bipolar disorder
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lithium valproic acid, carbamazepine lamotripine antiseizure drugs AND atypical olanzapine aripiprazole
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olanzapine
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weight gain OCD anxiety depression mania toruettes
atypical antipsycotic 1st line blocks 5HT2, dopamine an dH1 receptors best for negative symptoms mania bipolar wieght gian DM it is atypical for for old closets to quietly rister from A-Z |
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closapine
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agranulocytosis must watch closely WBC motior
atypical antipsycotic 1st line blocks 5HT2, dopamine an dH1 receptors best for negative symptoms mania bipolar wieght gian DM it is atypical for for old closets to quietly rister from A-Z |
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quetiapine
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weight gain atypical antipsycotic
1st line blocks 5HT2, dopamine an dH1 receptors best for negative symptoms mania bipolar wieght gian DM it is atypical for for old closets to quietly rister from A-Z |
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risperidone
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MC given FIRST atypical antipsycotic
1st line blocks 5HT2, dopamine an dH1 receptors best for negative symptoms mania bipolar wieght gian DM it is atypical for for old closets to quietly rister from A-Z |
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aripiprazole
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atypical antipsycotic
1st line blocks 5HT2, dopamine an dH1 receptors best for negative symptoms mania bipolar wieght gian DM it is atypical for for old closets to quietly rister from A-Z |
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ziprasodone
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weight loss!
1st line blocks 5HT2, dopamine an dH1 receptors best for negative symptoms mania bipolar wieght gian DM it is atypical for for old closets to quietly rister from A-Z |
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lithium
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LMNOP mood stability treats biopolar blocks replase of acut mania
lithium , movement tremor, nephrogenic DI, hypOthyroidism, preg NO ebseitn anomay malform great vessels ASD, small RV large RA displaced TV low TI |
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SSRI
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inhib serotonin reuptake
treats depression OCD anorexia social phobias |
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fluoxetine
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longest HL
SSRI inhib serotonin reuptake treats depression OCD anorexia social phobias; 2-4 wks to work SE: sexual dysfuncti, GI distress serotonin syndrome mix SNRI MAOi |
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paroxetine
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SSRI
inhib serotonin reuptake treats depression OCD anorexia social phobias; 2-4 wks to work SE: sexual dysfuncti, GI distress serotonin syndrome mix SNRI MAOi |
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sertraline
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SSRI
inhib serotonin reuptake treats depression OCD anorexia social phobias; 2-4 wks to work SE: sexual dysfuncti, GI distress serotonin syndrome mix SNRI MAOi |
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citalopram
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SSRI
inhib serotonin reuptake treats depression OCD anorexia social phobias; 2-4 wks to work SE: sexual dysfuncti, GI distress serotonin syndrome mix SNRI MAOi |
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serotoinin syndrome
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mix SNRI MAOi kava kava st john wart tryptophan cocain amphetamines ectasy cybutramine
HARM autonomc instability rigidity myoclonus hyperthermia diarrhea seizrues ocular clonus; give 5HT atnag cyporheptadine |
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treat serotonin syndrome
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cyprohepadine
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TCAs
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block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly give bicarb ***apropine like SE!!! |
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imipramine
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bedwetting TCA
block NE reuptake treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly give bicarb |
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amitriptyoine
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more SE TCA
block NE reuptake treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly give bicarb |
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desipramine
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less sedation TCA
block NE reuptake treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly give bicarb |
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nortriptyline
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less SE elderly okay TCA
block NE reuptake treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly give bicarb |
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clomipramine
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OCD TCA
block NE reuptake treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly give bicarb |
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doxepin
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TCA
block NE reuptake treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly give bicarb |
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amoxapine
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block NE reuptake
treats MDD fibromyalgia a blocking orthostatic HTN dizzy atropine like anticholinergic efefct tach urniary rtn SE: tri C anticholinergic cardiotox CNS tox confusion and hallucionation in elderly give bicarb TCA |
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MAOi
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MAOi of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists
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phenelzine
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MAOi of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists
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tranycypromine
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MAOi of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists
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isocarboxazind
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MAOi of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists
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selegiline
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MAOB for parkinsons
MAOB of NE atypical depression anxiety hypochondriasis nonselective inc NE serotoni dopamin hypertensive crisis w/ typramine ingestions give B agonists |
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SNRI
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inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression
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venlafaxine
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GAD SNRI
inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression |
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duloxetine
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diabetic pierpheral neuropathy SNRI and depression
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nefazodone
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inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression
SNRI |
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milnacipran
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fibromycalgia SNRI
inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression |
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sibutramine
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wieght loss SNRI
inhib serotioni and NE retuptate inc BP stimulent sedation nausea tx: depression |
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buproprion
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NDRI depression smoking cessation inc NE and dospmine sexual SE stim tach insomnia HA
lower seizure sthreshold in bulimics |
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mirtazapine
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a2 antag inc NE and serotonix potent 5HT 2/3 antag
atypical depression toxic sedation inc appetite weight gain dry mouth |
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maprotiline
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blocks NE reuptake toxicty sedaiton orthostatic hpotension
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trazodone
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inhib serotonin reuptake for insomnia inc REM atypical antidepressant high doses needed
SE pripaims sed postural hypotension trazobone |
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buspirone
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stim 5HT1 GAD no sed addiction or tolerance
no intereact w/ alcohol |
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class 1a antiarrythmics
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police department questions; TORSADES
Na procainamide, quinidne, disopyramide inc AP duration (slow O prolong 3) inc ERP inc QT affect atiral and ventricular arrhythmias reentrant and ectopic SVT/V tach |
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class 1A-C antiarrythmic
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the Police Department Question
The Little Man For Pushing Extacy Na Sodium-channel blockade: IC > IA > IB Increasing the ERP: IA > IC > IB (decreases) procainamide, disopyramide, quinidine lidocaine tocainamide, mexiletine poss phenytoin Flecainide, Propafenone, Encainide |
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class 1-4 type of drugs against?
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Na, BB, K, CCB
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procainamide
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class 1A antiarrythimc TORSADES
Na; inc AP duration (slow O prolong 3) inc ERP inc QT affect atiral and ventricular arrhythmias reentrant and ectopic SVT/V tach TREATS WPW! SE: drug induced lupus |
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disopyramide
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class 1A antiarrythimc TORSADES
Na; inc AP duration (slow O prolong 3) inc ERP inc QT affect atiral and ventricular arrhythmias reentrant and ectopic SVT/V tach |
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quididine
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cinchonism HA tinnitus TP TORSADES
class 1A antiarrythimc Na; inc AP duration (slow O prolong 3) inc ERP inc QT affect atiral and ventricular arrhythmias reentrant and ectopic SVT/V tach |
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class 1B antiarrhytmic
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The Little Man lidocaine, tocainide, mexilitine poss phenytoine (digitalis induced)
Na but dec AP duration decreases the rapid influx of sodium SO les refractory time SO poss arythmias treats ISCHEMIC or depolized ventricular tissue local anesthetic CNS inc CV depression |
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lidocaine
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treats acute V tach; class 1b
The Little Man lidocaine, tocainide, mexilitine poss phenytoine (digitalis induced) Na but dec AP duration decreases the rapid influx of sodium SO les refractory time SO poss arythmias treats ISCHEMIC or depolized ventricular tissue local anesthetic CNS inc CV SHORETED THE AP |
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mexiletine
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class 1b
The Little Man lidocaine, tocainide, mexilitine poss phenytoine (digitalis induced) Na but dec AP duration decreases the rapid influx of sodium SO les refractory time SO poss arythmias treats ISCHEMIC or depolized ventricular tissue local anesthetic CNS inc CV SHORETED THE AP |
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tocainide
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class 1b; poss pulm fibrosis
The Little Man lidocaine, tocainide, mexilitine poss phenytoine (digitalis induced) Na but dec AP duration decreases the rapid influx of sodium SO les refractory time SO poss arythmias treats ISCHEMIC or depolized ventricular tissue local anesthetic CNS inc CV SHORETED THE AP |
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class 1C
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for pushing ecstacy flecainide, encaindide, propafone
only affects phase 0 not AP duraiton; treats V tach SVT SE: inc refractory hyperK |
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class 2 BB
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BB proppanolo and esmol dec cAMP dec Ca currents and suppress abnormal paceakers prolong phase 4 by blocking the SA/AV nodes prolong refractory and AP
inc PR V tach SVt dec A fib/flutter SE: impotence AV block, sedaiton sleep alt treat w/ glucagon |
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flecainide
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class 1c
for pushing ecstacy flecainide, encaindide, propafone only affects phase 0 not AP duraiton; treats V tach SVT SE: inc refractory hyperK |
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encaindide
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class 1 c
for pushing ecstacy flecainide, encaindide, propafone only affects phase 0 not AP duraiton; treats V tach SVT SE: inc refractory hyperK |
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porpafenone
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class 1 c
for pushing ecstacy flecainide, encaindide, propafone only affects phase 0 not AP duraiton; treats V tach SVT SE: inc refractory hyperK |
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class 3 anrythmic
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K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone
TORSADES! inc AP duration and ERP inc QT interval |
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amiodarone
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treat SVT/Vtach
SE: pulm fiboriss, hepatotoxic, hypo/hyperthyroidism (iodine in it) corneal deposits skin deposits blue/gray skin; photodermatitis, neuro effects constpation CV brady heart block CHF check PFTs, LFTs, TFTs alters lipid membrane inc AP duraiton inc ERT in cQT interval torasaes (less than 1A and 3 |
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sotalol
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ventricular arrhythmias; atrial flutter and fibrillation
K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone TORSADES! inc AP duration and ERP inc QT interval |
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ibultilide
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SVT arrhythmias; atrial flutter and fibrillation conversion
K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone TORSADES! inc AP duration and ERP inc QT interval |
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bretylium
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new arrythmias and hypotension
treats: V tach and fib K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone TORSADES! inc AP duration and ERP inc QT interval |
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dofetilide
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K blockers inhib phase 3 DIBS dofetilide, ibutilide, bretylium, sotalol; amiodarone
TORSADES! inc AP duration and ERP inc QT interval |
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arrythmics that cause torsade
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1A, 3 and amiodarone
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class 4 antiarrythmics
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CCB verapamil --constipation and ginival hyperplasia and diltiazen
inc refractory period inc ERP inc PR dec conduction velocity prevent nodal arrythmias like SVT slows SA/AV firing |
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adenosine
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VD inc K out of cells hyperpolarize
dec Ica treats PSVT lasts 15s AV block flush hyptoension CHEST PAIN theophyllin blocks STRESS TEST not used in WPW |
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what does Mg treat?
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torsades and digoxin toxicity
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HCT
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treats hypertension
poss causes arrhythmias HYPER: uricemia, glycemia, lipidemia, calcemia (treats stones less risk of osteoporosis) avoid sulfa allergy hypoK, hypotension poss |
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loop diuretics
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calcium loosing; hyperuircemia; hypotension poss get rid of fluids
treats HTN may cause ototoxicity (do not combine w/ aminoglcycosides) also sulfa allergy |
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BB
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dec mortality AL inc EDV dec BP dec contracitlity dec HR inc ejection time dec MVO2
CI decomp CHF |
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ACEi
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protect against diabetic nephroapthy b/c dilate eff; treats HTN and CHF inhib remodeling
SE: hyperK, ocugh taste problems inc renin *dec risk of MI SE: angioedema rash NOT GIVEN IN PREG (RENAL) |
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clonidine
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A2 agonist centrally acting reboudn HTN
HL 8 hrs can cause bradycardia |
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methyldopa
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can be given in preg treat HTN
sedation +coombs |
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guanethidine
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blocks NE release??
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prazosin
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a1 blocker treats HTN 1st dose orhtostatic HTN
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hyralazine
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treats HTN dilates arterioles vasodilator dec AL for SEVERE HTN CHF
can be given in PREG also give BB to prevent the reflex tach SE: fluid rtn nause HA angina lupus like syndrome compensatory tach (CI in anigna CAD) |
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minoxidil
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hypertricosis
K channel blocker severe HTN or renal disease RF |
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nifedipine
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dihydropyridine vascular sm NOT the heart
HTn agnina prinzmetal's angina raynauds SE: peripheral edema constipation reflex tach good w/ bradycardia |
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nitroprusside
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malignant HTN short acting
inc cGMP direct relase of NO cyanide toxicity |
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fenoldopam
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dopamine D1 recptor agonist
relaxes renal ascular sm |
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diazoxide
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k channel opener hyperpolarizes and relaxes vascular sm
dec insulin release HYPERLGYCEMIA treats insulinoma |
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nitroglycerin
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VD, release NO in sm; in cGMP sm relax VEINS dec PL
relfex tach hyptension flusing HA monday diseasee can get tolerance dec EDV dev BP inc contractility as reflex; dec ejection time dec MVO2 used combo w/ BB dec the HR dec MVO2 |
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isosorbide dinitrate
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VD, release NO in sm; in cGMP sm relax VEINS dec PL
relfex tach hyptension flusing HA monday diseasee can get tolerance dec EDV dev BP inc contractility as reflex; dec ejection time dec MVO2 used combo w/ BB dec the HR dec MVO2 |
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digoxine
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40HL, inhib Na/K atpase indirect Na/Ca exchanger inc Ca postive inotropy stim vagus
tx: CHF A fib slows conduction inc parasym tone in vagus SE: cholinergic NV diarrhea chagne in color vision nausea anorexia inc PR de cQT scooping T wave inversion arrhythmias hyper K wrosened by RF hypoK give K, lidociane or phenytoin, cardiac pacer antidig Rab frag Mg |
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HTN drugs safe in preg 4
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methyldopa labetolol hydrazoline nafetapine
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statins
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HMG COA reductase inhib
no CH inc LFTs rhabdomyolysis |
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niacin
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dec LDL inc HDL inhib lipolysis in adipose
dec hepatic VLDL secreiton SE: flushed (give aspirin) hyperlgyc, hyperuricemia |
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bile acid resins
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dec LDL prevent intestinal reabsorption of bile acids liver must use CH to make more
SE: tastes bad Gi discompfort dec fat solubel vit CH gallstones tx: C diff |
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cholestyamine
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bile acid binding resins
dec LDL prevent intestinal reabsorption of bile acids liver must use CH to make more SE: tastes bad Gi discompfort dec fat solubel vit CH gallstones tx: C diff |
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colestipol
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bile acid binding resins
dec LDL prevent intestinal reabsorption of bile acids liver must use CH to make more SE: tastes bad Gi discompfort dec fat solubel vit CH gallstones tx: C diff |
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colesevalm
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bile acid binding resins
dec LDL prevent intestinal reabsorption of bile acids liver must use CH to make more SE: tastes bad Gi discompfort dec fat solubel vit CH gallstones tx: C diff |
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ezetimibe
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CH absopriton blocker
dec LDL prevent CH reabosrtpion at SI brush border inc LFTs |
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fibrates
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gemefibrozil clofibrate bezafibrate fenofibrate
dec TG upreg LPL inc TG clearance SE: myosistis hepatotoxic inc LFTs Ch gallstones |
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drugs that cuase urinary retention
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antichol atropine, TCAs antihist
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MTX
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folid acid analog inhib dihydrofolate reductase dec dTMP decDNA and proteins syn similar to TMP
tx: leukemia lymphomas sarcoma , abortiopn ectopic preg RA psoriais SE: myelosuppresion REV W/ LEUCOVORIN (folicinic acid); fatty liver, mucositis, teratogneic lung disease |
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5-FU
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pyrimiding analog complexes w/ folic acid inhib thymidiylate synthase; dec TMP, protien syn
tx: clon cancer solid; Actinic keratosis topical; synergy w/ MTX SE: myelosupp rescue w/ thymidine; photsn |
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6MP
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pruine inhib PRPP synthetase ribose HGPRTase leukemia lymphomas
NOT CLL or HL SE: BM, Gi Liver met by xanthine oxidase inc toxicity w/ allopurinol |
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thioguanine
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same as 6MP treats ALL bm depression liver allopurinol ok
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cytarabine ara C
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pyrimidine antag inhib DNA polym
AML, ALL NHL SE: luecopenia, TP megaloblastic anmia |
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cyclophosphamide
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alkylating agens X linked DNa need bioactivation by liver
Tx: NHL wegener's breast ovarian carinomas, immunsuppressant z E: mylosuppression, hemorrhagic cystotis, acroline toxic prevetns w/ MESNA inc risk bladder cnacer |
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nitrosurease
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car mustine lormustine
required bioact BBB CNs brain tumors CNS toxicity (dizzy/ataxia) |
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busulfan
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alk DNA
treat CML ablaste bm before bm transplant SE: pulm fibrosis hyperpig |
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carmustine
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nitroureas
reaquired bioact BBB brain tumors CNS toxicity |
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cisplastin/carboplatin
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xlink DNA testtiuclar bladder ovary lung
SE: npehrotox acoustic nerve damge (amin, vanco, loop)) |
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dactinomycin
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intercalacte in DNA
children-wilm ewings rhabdo children ACT out SE: myelosupp cardiotoxic |
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doxorubin
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gen FRs dna breaks dec replication
HL myelomas sarcoma, solid tumors cardiotoxic dilated CM myelsypp aloepcia |
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bleomycin
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FR formation breaks in DNA testicular cancer HL
SE: pulmonary fiboriss skinc hanges min myelosupp |
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hydroxyurea
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treat sickle cell CML meanoma
inhib ribonucleotide reductase dec DNA GI irritation alopecia |
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etoposide/teniposide
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inhib topo 2 inc DNA deg small cel protate testicular cacnier
myelosupp GI irritation alopecia |
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vincristine/ vinblastine
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alkaloid prevetns assembly MT
HL wilm's choriocarcionma blastine dec bM crinistine neurtoxic and paralytic ileus |
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paclitaxel
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inhb tubulin breakdown orvairna and breat
meylosupp/HS |
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tamoxifen
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inc risk of endometrial carcinoma partiaSERM
agonist in bone block E Rcl agonist hot flasthes |
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raloxifene
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antag endometrial cancer
SERM agonist in bone block E Rc |
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predinison
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tirgger apoptosiss even nodivdin cells
CLL HL immunosupp AI cushing like immunosupp cataract insomnia acne osteoporosis HTN PUD hyperglycemia pyschosis |
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trastuzumab
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herceptin monoclonal antibody against HER-2 erb-b2 kill breast cancer
ab dep cytotoxic met breast cancer SE: cardiotox |
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imitinib
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abl TK inhib
CML ALL GI stomal tumors fluid tn |
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rituximab
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monoclonal ab CD20 B cell NHL RA w/ MTX
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treat testicular cancer
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cisplatin belomycn etoposide
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interferes w/ MTs
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taxols bendazole griseofluvin colchicines vincrsitine/vinblastine
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PTU
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hyperthyroidism
inhib organification of iodid and coupling of TH syn; inhib tyrosal group SE rash agrnaulocytosis aplastic anemia dec peripheral conversion to T3 can be given in preg |
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methimazole
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hyperthyroidism
inhib organification of iodid and coupling of TH syn; inhib tyrosal group SE rash agrnaulocytosis aplastic anemia TERATOGEN |
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levothyroxine
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thryoxine replacemnt
tx: hypothyroidism myxedema SE: tach eat intolerance tremor arrythmias |
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triiodothyroxine
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thryoxine replacemnt
tx: hypothyroidism myxedema SE: tach eat intolerance tremor arrythmias |
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octeotride
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somatostatin-D cell sin gut/pancreas CNS dec endocrine and exocrin esec
dec splanchnic BF GI motility and Gb contraction inhib GI hormones, tx: acromegaly, thyrotropinioma ACTH tumors ZE syndrome carcinoid syndrome, VIPoma cholera intesthypermobility, gucagonoma, insulinoma, diarrheal disease portal HTN (varices) bleeding Pud |
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oxytocin
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paraventricular nucleus
stim labor uterine contration smilk let down controls uterine hemorrhage |
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desmopressin
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pituitary central DI and vWD treat
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demeclocyline
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ADH antag for siADH but can cause nephrogenic DI, photosn, bone/teeth abnormalities
--tetracycline |
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glucocorticoids
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prenisolone for liver disease, hydrocortison prednisone tramicinolon
dexamethazone beclomthasone--long acting dec prod of LT/PG inhib PLA2 and OCX2 tx: addison's disease inflammation immune suppresion asthma SE: iatrogenic cushing's |
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sulfonylurieas
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disulfiram effect, hypoglycemia, close K channels in B cell membrane so cell depolazises trigger insulin release via Cainfulx stim release fof insulin in T2DM
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glyburide
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sulfonylureas
disulfiram effect, hypoglycemia, close K channels in B cell membrane so cell depolazises trigger insulin release via Cainfulx stim release fof insulin in T2DM |
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glimepiride
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sulfonylureas
disulfiram effect, hypoglycemia, close K channels in B cell membrane so cell depolazises trigger insulin release via Cainfulx stim release fof insulin in T2DM |
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glipizide
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disulfiram effect, hypoglycemia, close K channels in B cell membrane so cell depolazises trigger insulin release via Cainfulx stim release fof insulin in T2DM
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biguanides
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metformin
dec lguconeogensis in liver inc glycolysis inc peripheral glc uptake insulin sn oral SE: LA, CI: renal failrue liver, CHF no IV contrast, PCOS okay in preg; WEIGHT LOSS don't have to tak ew/ meals used in combo lowers TG/CH do not use in pt w/ inc Cr monitor LFT's |
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glitazones
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thiazolidinediones: pioglitazone, rosiglitazone (inc risk of MI)
inc insulin sn in peripheral tissue binds PPAR nuclear transcriton reg; monotherapy SE: wieght gain edema, hepatotox Cv tox CI CHF monitor liver can use in renal diseaes |
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a glucosidase inhibitor
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inhib intestinal brush border, delayed sugar hydrolysis and abosrption; dec postprandial hyperglycemia; mono
GI dist do not use in liver cirrhosis inc Cr, IBD |
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acarbose
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a glucosidase inhib
inhib intestinal brush border, delayed sugar hydrolysis and abosrption; dec postprandial hyperglycemia; mono GI dist do not use in liver cirrhosis inc Cr, IBD |
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miglitol
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a glucosidase inhib
inhib intestinal brush border, delayed sugar hydrolysis and abosrption; dec postprandial hyperglycemia; mono GI dist do not use in liver cirrhosis inc Cr, IBD |
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pramlinitide
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amylin analog mimetics
dec glucagon and gastric empying hypoglycemia diarrhea postpradial hyperglycemia dec |
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GLP-1 analog
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exenatide
inc insulin dec glucagon release T2DM sugQ N/V pancreatitis |
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excenatide
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GLP-1
exenatide inc insulin dec glucagon release T2DM sugQ N/V pancreatitis |
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stigaglipitin
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incretin secreiton dec glucagon inc insulin delays gastric empying
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orlastat
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weight loss drugs inhib pancreatic lipases excrete fat
SE steatorrhea HA abdominal pain oily stool leakage |
