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37 Cards in this Set
- Front
- Back
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PT diuretics mOA
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CA inhibitors
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CA inhibitors
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Acetazolamide
dichlorphenamide methazolamide |
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methazolamide
SEs |
Met acid (loss hco3)
renal stones (incr pH) hypokalemia (upsteam of CD thus when lots of na arrives will crazy exchange for K) encephalopathy- nh3 reabsorbed easier) |
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methazolamide
uses |
= PT CA inhibitor
glaucoma (CA inc aqueous hum) epilepsy produce met. acid (altitude) prod. alk urine (excr. weak acids) |
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TAL diuretics mOA
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Na/K/cl symport inh.
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TAL Diur. named
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furosemide
bumetamide Ethacrynic Acid Torsemide |
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Lasix =
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Furosemide
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effect of NKCC2 inh
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usually most K recycles back through ROMK thus creating the + lumenal charge alowing mg,ca,na to come in paracellularly. inhibition abolishes this as well as na reabsorption bigtime
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Loop diuretics effect on blood electrolytes
pH ? |
dec K,Na,Ca,Mg in blood
High [na] arriving in CT drives high na/K exchange (K loss)but high []in lumen which drives high k/H (H secretion) equals Met. ALKALOSIS |
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Loop Diur
SEs |
HYpovolemia
HYpo-kal/calc/magnes-emia met Alkalosis ototoxicity-NKCC1 inner ear hyperglycemia (and lipids) hyperuricemia (OAT scene) ca stones |
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loop diuretics
uses |
HTN- not 1st choice
but PGs help DOC in acute severe pulm/syst edema hypercalcemia, drug OD Hyponatremia ( with hypertonic saline post abolishing kidneys ability to dilute & CONCENTRATE urine) |
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DCT diuretics mOA
and class |
Na/Cl symporter Inh.(NCC)
= thiazides and Thia-like |
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DCT diuretics Named and prototype
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all end in Thiazide
Hydrochlorothiazide is the Prototype |
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Thiazide like diuretics
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Chlorthalidone
Metholazone Indapamide |
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Thiazides effect on E-lytes
ph |
dec na,k,
increase Ca inc na/k exchange then k/H exchange with H secretion = met. ALKALOSIS |
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HYdroclorothiazide
SEs |
Hypokalemia
Metabolic alkalosis Hyperuricemia (OAT) inc glucose/lipids HYPERCALCEMIA (oppos of loops vol depletion hyponatremia (more than LOOP) sex dysfun |
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Thiazides uses
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mild/mod edema
idiopathic hyperCalcURIA (stones) dec Ca loss in osteoporosis HTN--------DOC often combo Nephrogenic Dia INsipidus (paradoxical-create hyperosmotic urine) |
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Collecting Tubule Diuretics
mOA |
Na Channel Inhibitors (ENAC)
& Aldo Receptor Antagonists (the K sparing) |
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K sparing Diuretics
types |
Na Channel (ENAC)Inhibitors (CD)
& Aldo Receptor Antagonists |
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Na Channel Inhibitors (ENAC)
& Aldo Receptor Antagonists named |
Na Channel Inhibitors-
amiloride, triamterene Aldo Receptor Antagonists- Spironolactone, Epleronone (SARA) |
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Triamterene mOA
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ENAC inhibitor in DCT
thus K sparing |
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amiloride mOA
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ENAC inhibitor in DCT
thus K sparing |
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ENAC inhibitors
USES |
Amiloride,Triamterene
Mild edema and combo with K wasting diuretics |
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Enac role in K secretion
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na/k pumps keeps intra Na down
Na enters ENAC in DCT depolarizing apical membrane and activating the ROMK k secreting channel. Thus coupling na absorption and K secretion in the DCT. Thus Enac inhibitors ANd SARA's abolish this and spare K |
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ENAC inhibitors
SE |
Amiloride,Triamterene
hyperkalemia met ACIDOSIS (Na absorption in the DCT drives Acid Secretion) Renal Stones (esp TRiam) |
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Amiloride,Triamterene
USes |
Enac Inh.( K spare)
weak diur, adjunct to K wasting |
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Aldo Rec Antagonists
SE |
Spirono, Eplero
Hyperkalemia Met ACIDosis (enac drives H+ secretion in DCT) Spironolactone -gynecomastia impotence |
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SARA uses
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adjunct to k wasting
Hyperaldosteronism ESPECIALLY in Hep Cirrhosis |
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Probenecid and Diuretics
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Prob inh OAT thus decreasing delivery of diuretics to the ductular LUmen
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NSAIDS and Diuretics
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inh. PGs = Dec. diuretic response
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Aminoglycosides and Diuretics
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with LOOP diuretic (REMEmBER NKCC) = increased OTOtoxicity
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Diuretics and DIGitalis
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Watch K wasting = Dig toxicity
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K sparing watch out for
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ACEI contribute to hyperKalemia
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OSMOTIC DIUretics
Named |
Mannitol and Urea (IV)
Glycerin and ISosorbide (Oral) |
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OSMOTIC DIUretics
uses |
Maintain urine Flow in ACUTE Renal failure (plus flush casts)
Draw fluid out of eyes and BRAIN Restore Osmolality in DIALYSIS DISEQU. SYND. |
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ADH R antagonists
named |
Conivaptan
Tolvaptan |
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Vaptan uses
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Conivaptan,Tolvaptan
cause aquaresis in hypervol. hyponatremia |
