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25 Cards in this Set
- Front
- Back
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Where do α2 analogs act? (2)
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- Centrally
- Peripherally |
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α2 analogs have what kind of response to dosage?
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Dose dependent
- As dosage increases, effect increases |
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α2 analog effects on CNS (2)
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- Inhibits NE release
- Analgesia |
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α2 analog effects on endocrine system (3)
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- Decrease insulin
- Decrease renin - Decrease ADH |
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α2 analog effects on respiratory system
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Respiratory depression
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α2 analog effects on vasculature
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Vasoconstriction
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α2 analog induced CV effects
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Biphasic response
- Initial surge increases MAP - MAP then decreases with no reflexive tachycardia Hypertension followed by hypotension with no tachycardia |
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α2 analog effects on urine production and output (2)
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- Promotes diuresis
- Increases urine output |
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α2 analog effects on musculature
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Muscle relaxation
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Adverse effects of α2 analogs
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Can enhance stress and lead to aggression
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Order of α2 receptor selectivity for:
Xylazine Romifidine Medetomidine Detomidine |
Medetomidine (dexmedetomidine) > romifidine > detomidine > xylazine
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What is dexmedetomidine favored over medetomidine? (2)
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- Decrease in side effects
- Can be used in cats |
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2 characteristics of romifidine compared to detomidine in horses
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- Greater hypotension produced
- Longer duration of sedative effects |
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2 characteristics of detomidine compared to romifidine in horses
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- More ataxia
- More familiarity with practicioners |
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Selectivity of α2 antagonists:
Yohimbine Tolazoline Atipamezole |
Atipamezole >>> Yohimbine > Tolazoline
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MoA of α2 antagonists
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Prevents inhibition of NE
- Reverses actions of α2 agonists |
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Primary usage of α2 agonists (2)
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- Analgesia
- Sedation |
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MoA of Xylazine
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α2 agonist
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MoA of Detomidine
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α2 agonist
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MoA of Medetomidine
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α2 agonist
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MoA of Dexmedetomidine
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α2 agonist
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MoA of Romifidine
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α2 agonist
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MoA of Yohimbine
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α2 antagonist
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MoA of Tolazoline
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α2 antagonist
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MoA of Atipamezole
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α2 antagonist
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