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15 Cards in this Set

  • Front
  • Back
Through what mechamism does glucagon work?
Gs protein (2nd messanger)
inc AC -> inc cAMP -> inc Protein Kinase A
Through what mechanism does tyrosine kinase --> protein phosphorylation?
Autophosphorylates
What hormones use tyrosine kinase?
Insulin
GH
IGF
Prolactin
(PIIG - or things that grow)
What is Thyroid Hormone's mech of action?
It's a steroid hormone (intracytoplasmic receptor-->altered transcription)
Name the HORMONES that work by increasing cAMP.
(from pituitary, placenta, plus 2Cs)
1. LH, FSH, TSH, PTH
2. HCG
3. CRH, Calcitonin
4. Glucagon
Name the RECEPTORS that increase cAMP (via adenylate cyclase)
1. B1 (inc contractility, renin, lipolysis)
2. B2 (vasodilation, bronchodilation, glucagon release (for glycogenolysis))
3. H2 (gastric acid secretion)
4. V2 (vasopressin, inc resorption of H2O in renal tubules)
5. D1: renal vessel vasodilation
What receptors work by decreasing cAMP?
M2: decrease HR
alpha2: dec insulin release, symp outflow
D2: (CNS)
What receptors work by increasing serum calcium/PKC?
1. H1: mucus, bronchoconstriction, pain, pruritis
2. alpha1: vasoconstriction
3. V1: vasoconstriction (ADH)
4. M1 (CNS)
5. M3: exocrine secretions
What HORMONES work by increasing serum Ca/Protein Kinase C?
(released by hypothalamus - except CRH - or by neurohypophysis; +Angiotensin II)
1. GnRH, GHRH, TRH
2. oxytocin, ADH (via V1)
3. Angiotensin II
Gs
Get set: inc AC--> inc cAMP
Gq
HAV 1 M&M
Gi
dec cAMP
G I'm MAD
Gi (inhibitory)
2 things that work by increasing cGMP (via guanylate cyclase)
1. ANP
2. EDRF
Name 6 things (endogenous) that vasodilate.
1. ANP
2. NO
3. PGI-2 and PGE-2
4. Substance P
5. Bradykinin
6. Histamine
6 things to know about ANP
1. offsets an increase in extracellular fluid volume (as witnessed by atria)
2. dilates peripheral and intrarenal vessels (via cGMP)
3. suppresses release of vasopressin (makes more urine)
4. inhibits angiotensin II from stimulating thirst and aldosterone)
5. Inhibits Na reabsorption
6. suppresses renin