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10 Cards in this Set
- Front
- Back
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what do you know about the aetiology of RA?
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- not much
- genetic factors - infection may be a trigger - higher incidence among smokers - 1-2% of any studied poopulation - more likely in 50s - more common in women |
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diagnosis of RA
history and examination.... diagnostic tests |
- active symmetrical arthritis for >6 weeks
-aged 50-55 - woman - joint swelling - joint pain -morning stiffness |
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diagnosis of RA
history and examination diagnostic tests... |
- rheumatoid factor >100 IU
-anti-cyclic citrullinated peptide (anti-CCP) antibody +ve - radiography - baseline then annually to monitor progress - disease activity score |
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treatment for RA
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- disease-modifying anti-rheumatic drugs
-corticosteroids -NSAIDS (with PPI) -TNF-alpha inhibitor -IL-6 inhibitor - B-cell modualtor |
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tell me more about
treatment for RA - disease-modifying anti-rheumatic drugs... -corticosteroids -NSAIDS -TNF-alpha inhibitor -IL-6 inhibitor - B-cell modualtor |
for mild, moderate and high disease presentation
-methotrexate (most common) (weekly) |
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tell me more about
treatment for RA - disease-modifying anti-rheumatic drugs -corticosteroids.... -NSAIDS -TNF-alpha inhibitor -IL-6 inhibitor - B-cell modualtor |
as an adjunct
-given with calcium and vit D supplements, with regular BMD scans |
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tell me more about
treatment for RA - disease-modifying anti-rheumatic drugs -corticosteroids -NSAIDS... -TNF-alpha inhibitor -IL-6 inhibitor - B-cell modulator |
as an adjunct
given with PPI |
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tell me more about
treatment for RA - disease-modifying anti-rheumatic drugs -corticosteroids -NSAIDS (with PPI) -TNF-alpha inhibitor... -IL-6 inhibitor - B-cell modulator |
high disease activity
infliximab more aggresive, IV infusion |
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tell me more about
treatment for RA - disease-modifying anti-rheumatic drugs -corticosteroids -NSAIDS (with PPI) -TNF-alpha inhibitor -IL-6 inhibitor.... - B-cell modulator |
as an adjunct with high disease activity
focilizumab |
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tell me more about
treatment for RA - disease-modifying anti-rheumatic drugs -corticosteroids -NSAIDS (with PPI) -TNF-alpha inhibitor -IL-6 inhibitor - B-cell modulator.... |
as an adjunct with high disease activity
rifuximab |
