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22 Cards in this Set

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  • Back
Classical histological cell of Hodgkin's Lymphoma?
Reed-Sternberg cell

"owl's eyes"

usulaly in Milieu - benign, inflammatory mixture of lymphocytes, histiocytes, plasma cells, neutrophils and eosinophils (usually rare in number)
Describe the spread of Hodgkin's Lymphoma
Contiguous - spreads along lymphatics in an orderly fashion
Staging of Hodgkin's Lymphoma

1) two or more lymph nodes

2) Lymph node region on both sides of diaphragm
1)Stage 2

2)Stage 3
further stageing classifcations

A = ?

B = ?
A = no symptoms

B = symptoms like unexplened WEIGHT LOSS, FEVER or NIGHT SWEATS
Non-classical Hodgkin's lymphoma is termed what?
Nodular Lymphocyte Predominate
Name the three types of classical Hodgkin's (4), in order of increasing severity?
1)Lymphocyte-rich HL

2)Nodular Sclerosis HL

3)Mixed Cellularity HL

4)Lymphocyte-depleted HL
In typical tumor (such as with non-Hodgkin's lymphoma, melanoma, etc) cells made mostly of ____ and minority by _____ ?
typical tumor

mostly tumor mass

minorty of lymphocytes (T & B cells)
In typical Hodgkin's lymphoma, cells made mostly of ____ and minority by _____ ?
Hodgkin's lymphoma

mostly lymphocytes

minorty tumor mass

Hodgkin's = tumor cell are MINORTY
vareant of the RS cell that has only 1 nucleus with a macro nucleolus
Hodgkin's cell, found in classical Hodgkin's
Most common, diagnostic cell in Hodgin's Lymphoma
Reed-Sternberg (RS) cell
RS cells are in this cell in teh Nodular sclerosing type of classical HL
Lacunar cell

"like a moat around a castle"
Type of cell found in the non-classical Nodular Lymphocyte Predominant HL?

Encircled by?
L & H cell

"popcorn cells", encircled by CD57+ T cells

...also stain positive for CD 20 (Bcell marker...not normally seen in classical HL)CD3
Age distribution of HL is described as ____ ? Occurs when?

15-34 (1st peak)

>50 (2nd peak)
Highest rate of incidnce (60%) amoungst all HL subtypes?
Nodular Sclerosis HL

remember....mostly females, mediastinal region lymph nodes, & sclerosing bands of COLLAGEN
What is the B cell marker found in Nodular Lyphocyte Predominant HL that is not found in classic HL?
Non-classic (Nodular lymphocyte predominant) HL shows what kind of lymphadenopathy?
Most aggressive clinical subtype of classical HL?

Least aggressive?
Lymphocyte-depleted HL (worse)

Lymphocyte-rich HL (best)

(mixed cellularity HL in teh middle)
Staining for Classical HL?

Nonclassical HL?
CD15+, CD30+, CD45- in RS cells (classical)

nonclassical = exact opposite in RS cell + CD3+, CD57+ (T cell marker) & CD20+ (B cell marker)
T/F In HL, the clinical grade of the cancer is greater than the stage?
F, Stage more significant than grade
Antigen-presenting dendritic cells located mainly in the skin and other reticulo-endothelial sites?
Langerhans Cell
Distinctive intracytoplasmic granules of Langerhans cells called?

Shaped like?
Birbeck granules

Tennis rackets/zippers
Name the 3 types of Langerhans Cell Histiocyosises (LCH)?
1)Acute disseminating LCH (Letter-Siwe dz): typically in infants and young children <2, cutaneous eruptions on trunk/scalp, RAPIDLY FATAL

2)Unifocal LCH: OLDER children; also called Eosinophilic Granuloma due to mixing of Langerhans cells with eosinophils, lymphocytes and plasma cells, CURED BY LOCAL EXCISIION/IRRADIATION/SPONTANENOUSLY (single lesion)

3)Multifuocal LCH (also called Eosinophilic Granuloma): YOUNGER children, multiple bone masses, lymphadenopathy/hepatosplenomegaly, 50% cases involve teh posterior pituitary, leading to Diabetes Insipidus