2/16 - Hodgkin Lymphoma

Front 1

Classical histological cell of Hodgkin's Lymphoma?

Back 1

Reed-Sternberg cell

"owl's eyes"

usulaly in Milieu - benign, inflammatory mixture of lymphocytes, histiocytes, plasma cells, neutrophils and eosinophils (usually rare in number)

Front 2

Describe the spread of Hodgkin's Lymphoma

Back 2

Contiguous - spreads along lymphatics in an orderly fashion

Front 3

Staging of Hodgkin's Lymphoma

1) two or more lymph nodes

2) Lymph node region on both sides of diaphragm

Back 3

1)Stage 2

2)Stage 3

Front 4

further stageing classifcations

A = ?

B = ?

Back 4

A = no symptoms

B = symptoms like unexplened WEIGHT LOSS, FEVER or NIGHT SWEATS

Front 5

Non-classical Hodgkin's lymphoma is termed what?

Back 5

Nodular Lymphocyte Predominate

Front 6

Name the three types of classical Hodgkin's (4), in order of increasing severity?

Back 6

1)Lymphocyte-rich HL

2)Nodular Sclerosis HL

3)Mixed Cellularity HL

4)Lymphocyte-depleted HL

Front 7

In typical tumor (such as with non-Hodgkin's lymphoma, melanoma, etc) cells made mostly of ____ and minority by _____ ?

Back 7

typical tumor

mostly tumor mass

minorty of lymphocytes (T & B cells)

Front 8

In typical Hodgkin's lymphoma, cells made mostly of ____ and minority by _____ ?

Back 8

Hodgkin's lymphoma

mostly lymphocytes

minorty tumor mass

Hodgkin's = tumor cell are MINORTY

Front 9

vareant of the RS cell that has only 1 nucleus with a macro nucleolus

Back 9

Hodgkin's cell, found in classical Hodgkin's

Front 10

Most common, diagnostic cell in Hodgin's Lymphoma

Back 10

Reed-Sternberg (RS) cell

Front 11

RS cells are in this cell in teh Nodular sclerosing type of classical HL

Back 11

Lacunar cell

"like a moat around a castle"

Front 12

Type of cell found in the non-classical Nodular Lymphocyte Predominant HL?

Encircled by?

Back 12

L & H cell

"popcorn cells", encircled by CD57+ T cells

...also stain positive for CD 20 (Bcell marker...not normally seen in classical HL)CD3

Front 13

Age distribution of HL is described as ____ ? Occurs when?

Back 13

Bimodal

15-34 (1st peak)

>50 (2nd peak)

Front 14

Highest rate of incidnce (60%) amoungst all HL subtypes?

Back 14

Nodular Sclerosis HL

remember....mostly females, mediastinal region lymph nodes, & sclerosing bands of COLLAGEN

Front 15

What is the B cell marker found in Nodular Lyphocyte Predominant HL that is not found in classic HL?

Back 15

CD20

Front 16

Non-classic (Nodular lymphocyte predominant) HL shows what kind of lymphadenopathy?

Back 16

peripheral

Front 17

Most aggressive clinical subtype of classical HL?

Least aggressive?

Back 17

Lymphocyte-depleted HL (worse)

Lymphocyte-rich HL (best)

(mixed cellularity HL in teh middle)

Front 18

Staining for Classical HL?

Nonclassical HL?

Back 18

CD15+, CD30+, CD45- in RS cells (classical)

nonclassical = exact opposite in RS cell + CD3+, CD57+ (T cell marker) & CD20+ (B cell marker)

Front 19

T/F In HL, the clinical grade of the cancer is greater than the stage?

Back 19

F, Stage more significant than grade

Front 20

Antigen-presenting dendritic cells located mainly in the skin and other reticulo-endothelial sites?

Back 20

Langerhans Cell

Front 21

Distinctive intracytoplasmic granules of Langerhans cells called?

Shaped like?

Back 21

Birbeck granules

Tennis rackets/zippers

Front 22

Name the 3 types of Langerhans Cell Histiocyosises (LCH)?

Back 22

1)Acute disseminating LCH (Letter-Siwe dz): typically in infants and young children <2, cutaneous eruptions on trunk/scalp, RAPIDLY FATAL

2)Unifocal LCH: OLDER children; also called Eosinophilic Granuloma due to mixing of Langerhans cells with eosinophils, lymphocytes and plasma cells, CURED BY LOCAL EXCISIION/IRRADIATION/SPONTANENOUSLY (single lesion)

3)Multifuocal LCH (also called Eosinophilic Granuloma): YOUNGER children, multiple bone masses, lymphadenopathy/hepatosplenomegaly, 50% cases involve teh posterior pituitary, leading to Diabetes Insipidus