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10 Cards in this Set
- Front
- Back
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Menopause occurs earlier in.... |
smokers |
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Premature menopause/ovarian failure is menopause before age ____ |
40 |
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Menopause increases the risk for... |
cardiovascular disease osteoporosis cancer stroke cognition fracture risk |
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What hormonal changes lead to Menopause |
Decreased estrogen & progesterone (begins at age 30)--> ovaries become unresponsive to gonadotropins w/ age (d/t dec # follicles)--> Decreased ovarian production of inhibin B--> Progesterone & 17beta-estradiol production in ovaries stops--> FSH & LH increased (unopposed) & DHEA dec |
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Common sx during menopausal transition |
vaginal sx- pH increase, dryness, itching, discomfort, dyspareunia---> atrophy
vasomotor sx- hot flashes w/ N/V
insomnia
memory loss & fatigue |
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Hot flash management |
SNRIs minimize alcohol, regular sex, sun, stress relief herbal tx= soy products & black cohosh
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Hormone replacement therapy (HRT) increases the risk of what?
(NOT recommended in MOST post-menopausal women) |
breast cancer, DVT, cardiovascular disease, stroke, cognitive changes |
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What is the safest option for HRT? |
Progesterone & Estrogen combos *lowest dose, shortest duration
-some of the neg effects of HDL & vascular are cancelled out (give estrogen only in pts w/o uterus) |
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CI for HRT |
thromboembolic Hx or disorder liver disease pregnancy breast or uterine cancer unexplained vaginal bleeding recent or active endometriosis
(use w. caution if high CV risk, gallbladder disease, or fibroids) (use transdermal if high triglycerides) |
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Androgens may benefit some women w/ low libido (Hypoactive Sexual Desire Disorder = low libido--> distress)
what are the neg SE? |
worsening lipid & cardiovascular profile acne clitoromegaly voice changes |
